Pubmed Link


80. Tian Y, Jacinto MP, Zeng Y, Yu Z, Qu J, Liu WR, Lin Q*. Genetically Encoded 2-Aryl-5-carboxytetrazoles for Site-Selective Protein Photo-Cross-Linking. J Am Chem Soc. 139(17):6078-6081. (2017)

79. Shen X, Shen S, Li J, Hu Q, Nie L, Tu C, Wang X, Orsburn B, Wang J, Qu J*. An IonStar experimental strategy for MS1 ion current-based quantification using ultra-high-field Orbitrap: reproducible, in-depth and accurate protein measurement in larger cohorts. J Proteome Res. [Epub ahead of print]. (2017)

78. Bima A, Pezic A, Sun C, Cameron FJ, Rodda C, Mei IV, Chiaroni-Clarke R, Dwyer T, Kemp A, Qu J, Carlin J, Ellis JA, Ponsonby AL*. Environmental and genetic determinants of two vitamin D metabolites in healthy Australian children. J Pediatr Endocrinol Metab. In Press. (2017)

77. Ayyar VS, Almon RR, DuBois DC, Sukumaran S, Qu J, Jusko WJ*. Functional proteomic analysis of corticosteroid pharmacodynamics in rat liver: Relationship to hepatic stress, signaling, energy regulation, and drug metabolism. J Proteomics. [Epub ahead of print]. (2017)



76. Tu C, Mojica W, Straubinger RM, Li J, Shen S, Qu M, Nie L, Roberts R, An B, Qu J*. Quantitative proteomic profiling of paired cancerous and normal colon epithelial cells isolated freshly from colorectal cancer patients. Proteomics Clin Appl. [Epub ahead of print]. (2016)

75. Tu C, Shen S, Sheng Q, Shyr Y, Qu J*. A peptide-retrieval strategy enables significant improvement of quantitative performance without compromising confidence of identification. J Proteomics. 152:276-282. (2016)

74. Welle KA, Zhang T, Hyrohorenko JR, Shen S, Qu J, Ghaemmaghami S. Time-resolved analysis of proteome dynamics by TMT-SILAC hyperplexing. Mol Cell Proteomics. 15(12):3551-3563. (2016)

73. Tu C, Bu Y, Vujcic M, Shen S, Li J, Qu M, Hangauer D, Clements JL*, Qu J*. Ion Current-based Proteomics Profiling in Understanding the Inhibitory Effect of Tumor Necrosis Factor Alpha on Myogenic Differentiation. J Proteome Res. 15(9):3147-57. (2016)

72. Tu C, Li J, Shen S, Sheng Q, Shyr Y, Qu J*. Performance Investigation of Protoemic Identification by HCD/CID Fragmentations in Combination with High/Low-Resolution Detectors on a Tribrid, High-Field Orbitrap Instrument. PLoS One. 11(7):e0160160. (2016)

71. Li YW, Guo J, Shen H, Li J, Yang N, Frangou C, Wilson KE, Zhang Y, Mussell AL, Sudol M, Farooq A, Qu J, Zhang J*. Phosphorylation of Tyr188 in the WW domain of YAP1 plays an essential roe in YAP1-induced cellular transformation. Cell Cycle. 15(18):2497-505. (2016)

70. Qu M, An B, Shen S, Zhang M, Shen X, Duan X, Balthasar JP, Qu J*. Qualitative and quantitative characterization of protein therapeutics with liquid chromatography and mass spectrometry. Mass Spectrom Rev. [Epub ahead of print]. (2016)

69. Shen S, Jiang X, Li J, Straubinger RM, Suarez M, Tu C, Duan X, Thompson AC, Qu J*. Large-Scale, Ion-Current-Based Proteomic Investigation of the Rat Striatal Proteome in a Model of Short- and Long-Term Cocaine Withdrawal. J Proteome Res. 15(5):1702-16. (2016)

68. Yuan X, Cao J, He X, Serra R, Qu J, Cao X, Yang S*. Ciliary IFT80 balances canonical versus non-canonical hedgehog signaling for osteoblat differentiation. Nat Commun. 7:11024. (2016)

67. Zhang T, Shen S, Qu J, Ghaemmaghami S*. Global Analysis of Cellular Protein Flux Quantifies the Selectivity of Basal Autophagy. Cell Rep. 14(10):2426:39. (2016)

66. Shen S, Li J, Hilchey S, Shen X, Tu C, Qiu X, Ng A, Ghaemmaghami S, Wu H, Zand M, Qu J*. An Ion-Current-Based Temporal Proteomic Profiling of Influenza A Virus Infected Mouse Lungs Revealed Underlying Mechanisms of Altered Integrity of the Lung Microvascular Barrier. J Proteome Res. 15(2):540-53. (2016)



65. Shen X, Nair B, Mahajan SD, Jiang X, Li J, Shen S, Tu C, Hsiao CB, Schwartz SA, Qu J*. New insights into the disease progression control mechanisms by comparing Long-term-non-progressors vs. Normal-progressors among HIV-1 positive patients using an ion current-based MS1 proteomics profiling. J Proteome Res. 14(12):5225-39 (2015)

64. Tu C, Sheng Q, Li J, Ma D, Shen X, Wang X, Shyr Y, Yi Z, Qu J*. Optimization of Search Engines and Postprocessing Approaches to Maximize Peptide and Protein Identification for High-Resolution Mass Data. J Proteome Res. 14(11):4662-73 (2015)

63. Shen X, Hu Q, Li J, Wang J, Qu J*. Experimental Null Method to Guide the Development of Technical Procedures and to Control False-Positive Discovery in Quantitative Proteomics. J Proteome Res. 14(10):4147-57 (2015)

62. Lott K, Mukhopadhyay S, Li J, Wang J, Yao J, Sun Y, Qu J, Read LK. Arginine methylation of DRBD18 differentially impacts its opposing effects on the trypanosome transcriptome. Nucleic Acids Res. pii: gkv428. (2015)

61. Morales Y, Nitzel DV, Price OM, Gui S, Li J, Qu J, Hevel JM. Redox control of protein arginine methyltransferase (PRMT1) activity. J Biol Chem. pii: jbc.M115.651380. (2015)

60. Tu C, Beharry KD, Shen X, Li J, Wang L, Aranda JV, Qu J*. Proteomic profiling of the retinas in a neonatal rat model of oxygen-induced retinopathy with a reproducible ion-current-based MS1 approach. J Proteome Res. 14(5):2109-20 (2015)

59. An B, Zhang M, Johnson RW, Qu J*. Surfactant-Aided Precipitation/On-Pellet-Digestion (SOD) Procedure Provides Robust and Rapid Sample Preparation for Reproducible, Accurate and Sensitive LC-MS Quantification of Therapeutic Protein in Plasma and Tissues. Anal Chem. 87(7):4023-9 (2015)

58. Kamisoglu K, Sukumaran S, Nouri-Nigjeh E, Tu C, Li J, Shen X, Duan X, Qu J, Almon RR, DuBois DC, Jusko WJ, Androulakis IP. Tandem analysis of transcriptome and proteome changes after a single dose of corticosteroid: a systems approach to liver function in pharmacogenomics. OMICS. 19(2):80-91 (2015)



57. Zhang T, Price JC, Nouri-Nigjeh E, Li J, Hellerstain MK, Qu J, Ghaemmaghami S. Kinetics of precursor labeling in stable isotope labeling in cell cultures (SILAC) experiments. Anal Chem. 86(22):11334-41 (2014)

56. Tu C, Sheng Q, Li J, Shen X, Zhang M, Shyr Y, Qu J*. ICan: An Optimized Ion Current-Based Quantification Procedure with Enhanced Quantitative Accuracy and Sensitivity in Biomarker Discovery. J Proteome Res.13(12):5888-97 (2014)

55. An B, Zhang M, Qu J*. Towards Sensitive and Accurate Analysis of Antibody Biotherapeutics by LC/MS. Drug Metab. Dispos. 42(11):1858-66 (2014)

54. Nouri-Nigjeh E, Sukumaran S, Tu C, Li J, Shen X, Duan X, DuBois DC, Almon RR, Jusko WJ, Qu J*. Highly Multiplexed and Reproducible Ion Current-Based Strategy for Large-Scale Quantitative Proteomics and the Application to Protein Expression Dynamics Induced by Methylprednisolone in 60 Rats. Anal Chem. 86(16):8149-57 (2014)

53. Gui S, Gathiaka S, Li J, Qu J, Acevedo O, Hevel JM. A Remodeled Protein Arginine Methyltransferase 1 (PRMT1) Generates Symmetric Dimethylarginine. J Biol. Chem.289(13):9320-7 (2014)

52. Shen X, Young R, Canty JM, Qu J*. Quantitative proteomics in cardiovascular research: Global and targeted strategies. Proteomics Clin Appl. 8(7-8):488-505 (2014)

51. Browne RW, Weinstock-Guttman B, Zivadinov R, Horakova D, Bodziak ML, Tamaño-Blanco M, Badgett D, Tyblova M, Vaneckova M, Seidl Z, Krasensky J, Bergsland N, Ramasamy DP, Hagemeier J,Qu J, Havrdova E, Ramanathan M. Serum lipoprotein composition and vitamin D metabolite levels in clinically isolated syndromes: Results from a multi-center study. J Steroid Biochem Mol Biol. 143C:424-433 (2014)

50. Qu J*, Young R, Page BJ, Shen X, Tata N, Li J, Duan X, Fallavollita JA, Canty JM Jr. Reproducible Ion-Current-Based Approach for 24-Plex Comparison of the Tissue Proteomes of Hibernating versus Normal Myocardium in Swine Models. J Proteome Res. 13(5):2571-84 (2014)

49. Tu C, Li J, Sheng Q, Zhang M, Qu J*. Systematic assessment of survey scan and MS2-based abundance strategies for label-free quantitative proteomics using high-resolution MS data. J Proteome Res. 13(4):2069-79. (2014)

48. Nouri-Nigjeh E, Zhang M, Ji T, Yu H, An B, Duan X, Balthasar J, Johnson RW, Qu J*. Effects of calibration approaches on the accuracy for LC-MS targeted quantification of therapeutic protein. Anal Chem. 86(7):3575-84. (2014)

47. Tu C, Mammen MJ, Li J, Shen X, Jiang X, Hu Q, Wang J, Sethi S, Qu J*. Large-scale, ion-current-based proteomics investigation of bronchoalveolar lavage fluid in chronic obstructive pulmonary disease patients. J Proteome Res. 13(2):627-39. (2014)



46. Tu C, Li J, Jiang X, Sheflin LG, Pfeffer BA, Behringer M, Fliesler SJ, Qu J*. Ion-current-based proteomic profiling of the retina in a rat model of Smith-Lemli-Opitz syndrome. Mol Cell Proteomics. 12(12):3583-98 (2013)

45. Lott K, Li J, Fisk JC, Wang H, Aletta JM, Qu J*, Read LK. Global proteomic analysis in trypanosomes reveals unique proteins and conserved cellular processes impacted by arginine methylation. J Proteomics. 91:210-25. (2013)

44. Weinstock-Guttman B, Zivadinov R, Horakova D, Havrdova E, Qu J, Shyh G, Lakota E, O'Connor K, Badgett D, Tamano-Blanco M, Tyblova M, Hussein S, Bergsland N, Willis L, Krasensky J, Vaneckova M, Seidl Z, Ramanathan M. Lipid profiles are associated with lesion formation over 24 months in interferon-beta treated patients following the first demyelinating event. J Neurol Neurosurg Psychiatry. 84(11):1186-91. (2013)

43. Lo CY, Antonopoulos A, Gupta R, Qu J, Dell A, Haslam SM, Neelamegham S. Competition between core-2 GlcNAc-transferase and ST6GalNAc-transferase regulates the synthesis of the leukocyte selectin ligand on human P-selectin glycoprotein ligand-1. J Biol Chem. 288(20):13974-87. (2013)

42. Zivadinov R, Treu CN, Weinstock-Guttman B, Turner C, Bergsland N, O'Connor K, Dwyer MG, Carl E, Ramasamy DP, Qu J, Ramanathan M. Interdependence and contributions of sun exposure and vitamin D to MRI measures in multiple sclerosis. J Neurol Neurosurg Psychiatry. 84(10):1075-81. (2013)

41. Fisk JC, Li J, Wang H, Aletta JM, Qu J*, and Read LK. Proteomic analysis reveals diverse classes of arginine methylproteins in mitochondria of trypanosomes. Mol. Cell. Proteomics. 12(2):302-11 (2013)

40. Horakova D, Zivadinov R, Weinstock-Guttman B, Havrdova E, Qu J, Tamaño-Blanco M, Badgett D, Tyblova M,  Bergsland N, Hussein S, Willis L, Krasensky J, Vaneckova M, Seidl Z, Lelkova P, Dwyer MG, Zhang M, Yu H, Duan X, Kalincik T, Ramanathan M. Environmental Factors Associated with Disease Progression After the First Demyelinating Event: Results from the Multi-Center SET Study. PLOS One. 8(1):e53996. (2013)



  1. 39. Jackson CA, Yadav N, Min S, Li J, Milliman EJ, Qu J, Chen YC, and Yu MC. Proteomic analysis of interactors for yeast protein arginine methyltransferase hmt1 reveals novel substrate and insights into additional biological roles. Proteomics 12:3304-14 (2012).
  2. 38. Tu CJ, Li J, Bu YH, Hangauer D,  Qu J* An ion-current-based, comprehensive and reproducible proteomic strategy for comparative characterization of the cellular responses to novel anti-cancer agents in a prostate cell model. J. Proteomics 77:187-201(2012).
  3. 37. Duan X, Dai L, Chen SC, Balthasar JP, Qu J*. Nano-scale lc/srm-ms and on-the-fly orthogonal array optimization for targeted quantification of therapeutic monoclonal antibodies: an application in sensitive and accurate preclinical analysis of a chimeric anti-cea antibody. J. Chromatogr. A, 1251:63-73 (2012)
  4. 36. Duan X, Abuqayyas LM, Dai L, Balthasar JP, Qu J*. High-throughput method development for sensitive, accurate and reproducible quantification of therapeutic monoclonal antibodies in tissues using orthogonal array optimization and nano-LC/SRM/MS. Anal Chem. 84:4373-82 (2012)
  5. 35. Jamesdaniel S, Coling D, Hinduja S, Ding D, Li J, Cassidy L, Seigel GM, Qu J, Salvi R. Cisplatin-induced ototoxicity is mediated by nitroxidative modification of cochlear proteins characterized by nitration of lmo4. J Biol Chem. 287:18674-86 (2012)


  1. 34. Weinstock-Guttman B, Zivadinov R, Qu J(co-first author), Cookfair D, Duan X, Bang E, Bergsland N, Hussein S, Cherneva M, Willis L, Heininen-Brown M, Ramanathan M. Vitamin D metabolites are associated with clinical and MRI outcomes in multiple sclerosis patients. J Neurol Neurosurg Psychiatry. 82:189-95 (2011)
  2. 33. Zimmer SL, McEvoy SM, Li J, Qu J, Read LK. A novel member of the RNase D exoribonuclease family functions in mitochondrial guide RNA metabolism in Trypanosoma brucei. J Biol Chem.286:10329-40 (2011)
  3. 32. Tu CJ, Li J, Young RF, Page BJ, Engler F, Halfon MS, Canty JM, Qu J*. A Combinatorial Peptide Ligand Libraries Treatment Followed by a Dual-Enzyme, Dual-Activation Approach on a nano-flow LC/Orbitrap/ETD for Comprehensive Analysis of Swine Plasma Proteome. Anal Chem, 83:4802-13 (2011)
  4. 31. Krishnatry AS, Kamei T, Wang H, Qu J, Fung HL. Identification of nitroglycerin-induced cysteine modifications of pro-matrix metalloproteinase-9. Rapid Commun Mass Spectrom. 25:2291-8 (2011)


  1. 30. Duan X, Weinstock-Guttman B, Wang H, Bang E, Li J, Ramanathan M, Qu J* Ultra-sensitive Quantification of Serum Vitamin D Metabolites Using Selective Solid Phase Extraction Coupled to Micro-flow Liquid Chromatography and Isotope-Dilution Mass Spectrometry. Anal. Chem. 82: 2488–2497 (2010)
  2. 29. Cao J, Gonzalez-Covarrubias V, Straubinger RM, Wang H, Duan X, Yu H,  Qu J* A rapid, reproducible, on-the-fly orthogonal array optimization method for targeted protein quantification by LC/MS and its application for accurate and sensitive quantification of carbonyl reductases in human liver. Anal. Chem. 82: 2680-2689 (2010)
  3. 28. Qu J, Lesse AJ, Brauer AL, Cao J, Gill SR, Murphy TF. .Proteomic Expression Profiling of Haemophilus influenzae Grown in Pooled Human Sputum from Adults with Chronic Obstructive Pulmonary Disease Reveal Antioxidant and Stress Responses. BMC Microbiol. 10: 162 (2010)
  4. 27. Song W, Wang Y, Yu Z, Vera CI, Qu J, Lin Q. A metabolic alkene reporter for spatiotemporally controlled imaging of newly synthesized proteins in Mammalian cells. ACS Chem Biol. 5:875-85 (2010)
  5. 26. Duan X, Engler FA, Qu J*. Electron transfer dissociation coupled to an Orbitrap analyzer may promise a straightforward and accurate sequencing of disulfide-bridged cyclic peptides: a case study. J Mass Spectr. 45:1477-82 (2010)


  1. 25. Yu AM, Qu J, Felmlee MA, Cao J, Jiang XL. Quantitation of human cytochrome P450 2D6 protein with immunoblot and mass spectrometry analysis. Drug Metab. Dispos. 37: 170-7 (2009).
  2. 24. Wang H; Straubinger RM; Aletta JM; Cao J; Duan X; Yu H; Qu J*. Accurate localization and relative quantification of arginine methylation using nanoflow liquid chromatography coupled to electron transfer dissociation and orbitrap mass spectrometry. J Am Soc Mass Spectrom 20: 507-19 (2009).
  3. 23. Duan X; Young R; Straubinger RM; Page, BJ; Cao J; Wang H; Yu H; Canty JM;  Qu J* A Straightforward and Highly Efficient Precipitation/On-pellet Digestion Procedure Coupled to a Long Gradient Nano-LC Separation and Orbitrap Mass Spectrometry for Label-free Expression Profiling of the Swine Heart Mitochondrial Proteome. J. Proteome Res. 6: 2838-2850 (2009).
  4. 22. Shah MB, Ingram-Smith C, Cooper LL, Qu J, Meng Y, Smith KS, Gulick AM. The 2.1 A crystal structure of an acyl-CoA synthetase from Methanosarcina acetivorans reveals an alternate acyl-binding pocket for small branched acyl substrates.  Proteins. 77(3):685-98 (2009).
  5. 21. Vagin V, Wohlschlegel J, Qu J, Jonsson X, Huang X, Chuma S, Girard A, Sachidanandam R, Hannon G. Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members. Gene and Development. 23(15): 1749-1762 (2009).
  6. 20. Lee MH, Koria P, Qu JAndreadis ST. JNK phosphorylates β-catenin and regulates adherens junctions FASEB J. 23: 3874-3883 (2009).

2008 & Before 2008

  1. 19. Gaspar JR; Qu J; Straubinger NL; Straubinger RM. Highly selective and sensitive assay for paclitaxel accumulation by tumor cells based on selective solid phase extraction and micro-flow liquid chromatography coupled to mass spectrometry. Analyst 133: 1742-8 (2008).
  2. 18. Song W; Wang Y; Qu J; Lin Q. Selective functionalization of a genetically encoded alkene-containing protein via "photoclick chemistry" in bacterial cells. J Am Chem Soc 130: 9654-5 (2008).
  3. 17. Song W; Wang Y; Qu J; Madden MM; Lin Q. A photoinducible 1,3-dipolar cycloaddition reaction for rapid, selective modification of tetrazole-containing proteins. Angew Chem Int Ed Engl 47: 2832-5 (2008).
  4. 16. Yu H; Straubinger RM; Cao J; Wang HS; Qu J*. Ultra-sensitive quantification of paclitaxel using selective solid-phase extraction in conjunction with reversed-phase capillary liquid chromatography/tandem mass spectrometry. J. Chromatog. A 1210: 160-7 (2008).
  1. 15. Drake EJ; Cao J; Qu J; Shah MB; Straubinger RM; Gulick AM. The 1.8 Å crystal structure of PA2412, an MbtH-like protein from the pyoverdine cluster of Pseudomonas aeruginosa. J. Biol. Chem. 282: 20425-34 (2007).
  2. 14. Qu J*; Qu Y; Straubinger RM. Ultra-sensitive quantification of corticosteroids in plasma samples using selective solid-phase extraction and reversed-phase capillary high-performance liquid chromatography/tandem mass spectrometry. Anal. Chem. 79: 3786-93 (2007).
  3. 13. Straubinger RM; Krzyzanski W; Francoforte CM; Qu J. Applications of quantitative pharmacodynamic effect markers in drug target identification and therapy development. Anticancer Res. 27: 1237-46 (2007).
  1. 12. Liang Q; Qu J; Luo G; Wang Y. Rapid and reliable determination of illegal adulterant in herbal medicines and dietary supplements by LC/MS/MS. J Pharm Biomed Anal 40: 305-11 (2006).
  2. 11. Qu J; Jusko WJ; Straubinger RM. Utility of cleavable isotope-coded affinity-tagged reagents for quantification of low-copy proteins induced by methylprednisolone using liquid chromatography/tandem mass spectrometry. Anal. Chem. 78: 4543-52 (2006).
  3. 10. Qu J; Straubinger RM. Improved sensitivity for quantification of proteins using triply charged cleavable isotope-coded affinity tag peptides. Rapid Commun. Mass Spect. 19: 2857-64 (2005).
  4. 9. Qu J; Liang Q; Luo G; Wang Y. Screening and identification of glycosides in biological samples using energy-gradient neutral loss scan and liquid chromatography tandem mass spectrometry. Anal. Chem. 76: 2239-47 (2004).
  5. 8. Qu J; Wang Y; Luo G; Wu Z; Yang C. Validated quantitation of underivatized amino acids in human blood samples by volatile ion-pair reversed-phase liquid chromatography coupled to isotope dilution tandem mass spectrometry. Anal. Chem. 74: 2034-40 (2002).
  6. 7. Qu J; Chen W; Luo G; Wang Y; Xiao S; Ling Z; Chen G. Rapid determination of underivatized pyroglutamic acid, glutamic acid, glutamine and other relevant amino acids in fermentation media by LC-MS-MS. Analyst 127: 66-9 (2002).
  7. 6. Qu J; Wang Y; Luo G; Wu Z. Identification and determination of glucuronides and their aglycones in Erigeron breviscapus by liquid chromatography-tandem mass spectrometry. J Chromatogr A 928: 155-62 (2001).
  8. 5. Qu J; Wang Y; Luo G. Determination of scutellarin in Erigeron breviscapus extract by liquid chromatography-tandem mass spectrometry. J Chromatogr A 919: 437-41 (2001).
  9. 4. Qu J; Wu Z; Luo G; Liu M. Neonate screening for phenylketonuria by LC/MS/MS. Chemical Journal of Chinese Universities 21: 210-2 (2000).
  10. 3. Qu J; Wang Y; Luo G; Wu Z. Quantitation of Denzanyisu in biological matrix by LC/MS/MS. ACTA Pharmaceutica Sinica 35: 139-41 (2000).
  11. 2. Qu J; Luo G; Wu Z. The advancement of HPLC-NMR technologies. Chinese Journal of Analytical Chemistry 28: 976-81 (1999).
  12. 1. Luo G; Qu J; Wang S. Determination of aluminum in the extraction of mouse brain by capillary electrophoresis. Am. Biotech. Lab. 17: 20-2 (1999).

Update date: May, 2017