Shichen Shen

Introduction

I received my B.S. degree in Pharmaceutical Sciences from Fudan University, in 2012. My research focus during undergraduate was pharmacological characterization of skeletal TRPV1 receptor. Now I'm pursuing a Ph.D. degree in biochemistry under the mentorship of Dr. Qu. My current research interests encompass: I) Optimization and application of ion-current-based MS1 proteomics for large-scale quantitative analysis of clinical and pharmaceutical samples; II) Discovery and validation of potential biomarker candidates for cardiovascular diseases using both global and targeted proteomics approaches; III) Method development for investigation of protein PTMs (e.g. serine/threonine phosphorylation and arginine methylation).

Publications

1. Shen X, Nair B, Mahajan SD, Jiang X, Li J, Shen S, Tu C, Hsiao CB, Schwartz SA, Qu J*. New insights into the disease progression control mechanisms by comparing Long-term-non-progressors vs. Normal-progressors among HIV-1 positive patients using an ion current-based MS1 proteomics profiling. J Proteome Res. 14(12):5225-39 (2015)

2. Shen S, Li J, Hilchey S, Shen X, Tu C, Qiu X, Ng A, Ghaemmaghami S, Wu H, Zand M, Qu J*. An Ion-Current-Based Temporal Proteomic Profiling of Influenza A Virus Infected Mouse Lungs Revealed Underlying Mechanisms of Altered Integrity of the Lung Microvascular Barrier. J Proteome Res. 15(2):540-53. (2016)

3. Zhang T, Shen S, Qu J, Ghaemmaghami S*. Global Analysis of Cellular Protein Flux Quantifies the Selectivity of Basal Autophagy. Cell Rep. 14(10):2426:39. (2016)

4. Shen S, Jiang X, Li J, Straubinger RM, Suarez M, Tu C, Duan X, Thompson AC, Qu J*. Large-Scale, Ion-Current-Based Proteomic Investigation of the Rat Striatal Proteome in a Model of Short- and Long-Term Cocaine Withdrawal. J Proteome Res. 15(5):1702-16. (2016)

5. Qu M, An B, Shen S, Zhang M, Shen X, Duan X, Balthasar JP, Qu J*. Qualitative and quantitative characterization of protein therapeutics with liquid chromatography and mass spectrometry. Mass Spectrom Rev. [Epub ahead of print]. (2016)

6. Tu C, Li J, Shen S, Sheng Q, Shyr Y, Qu J*. Performance Investigation of Protoemic Identification by HCD/CID Fragmentations in Combination with High/Low-Resolution Detectors on a Tribrid, High-Field Orbitrap Instrument. PLoS One. 11(7):e0160160. (2016)

7. Tu C, Bu Y, Vujcic M, Shen S, Li J, Qu M, Hangauer D, Clements JL*, Qu J*. Ion Current-based Proteomics Profiling in Understanding the Inhibitory Effect of Tumor Necrosis Factor Alpha on Myogenic Differentiation. J Proteome Res. [Epub ahead of print]. (2016)

Update date: May, 2017