Zhen Yan, Ph.D.

Selected Publications:

1.               Zhong P, Hu Z, Jiang H, Yan Z, Feng J (2017) Dopamine induces oscillatory activity in human midbrain neurons with Parkin mutations. Cell Reports 19:1033-1044. [PDF file] ^^^

2.               Wei J, Zhong P, Qin L, Tan T, Yan Z (2017) Chemicogenetic restoration of the prefrontal cortex to amygadala pathway ameliorates stress-induced deficits. Cerebral Cortex (in press). [PDF file] ***

3.               Seo JS, Zhong P, Liu A, Yan Z, Greengard P (2017) Elevation of p11 in lateral habenula mediates depression-like behavior. Molecular Psychiatry (in press). [PDF file] ***

4.               Cheng J, Liu A, Shi MY, Yan Z (2017) Disrupted glutamatergic transmission in prefrontal cortex contributes to behavioral abnormality in an animal model of ADHD. Neuropsychopharmacology (in press). [PDF file] ***

5.               Yang J, Liu AY, Tang B, Luo D, Lai YJ, Zhu BL, Wang XF, Yan Z, Chen GJ (2017) Chronic nicotine differentially affects murine transcriptome profiling in isolated cortical interneurons and pyramidal neurons. BMC Genomics 18:194. [PDF file] !!!

6.               Seo JS, Wei J, Qin L, Kim Y, Yan Z, Greengard P (2016) Molecular and cellular basis for stress-induced depression. Molecular Psychiatry (in press). [PDF file] ***

7.               Yan Z, Kim E, Datta D, Lewis D, Soderling S (2016) Synaptic actin dysregulation, a convergent mechanism of mental disorders?. J. Neuroscience 36:11411-7. [PDF file] (review) ***

8.               Qin L, Liu W, Ma K, Wei J, Zhong P, Cho K, Yan Z (2016) The ADHD-linked human dopamine D4 receptor variant D4.7 induces over-suppression of NMDA receptor function in prefrontal cortex. Neurobiology of Disease 95:194-203. [PDF file] ***

9.               Deng Y, Wei J, Cheng J, Zhong P, Xiong Z, Liu A, Lin L, Chen SD, Yan Z (2016) Partial amelioration of synaptic and cognitive deficits by inhibiting cofilin dephosphorylation in an animal model of Alzheimer's disease. J. Alzheimer's Disease 53:1419-32. [PDF file] !!!

10.            Wei J, Xiong Z, Lee JB, Cheng J, Duffney LJ, Matas E, Yan Z (2016) Histone modification of Nedd4 ubiquitin ligase controls the loss of AMPA receptors and cognitive impairment induced by repeated stress. J. Neurosci. 36:2119-30. [PDF file] ***

11.            Zhong P, Liu W, Yan Z (2016) Aberrant regulation of synchronous network activity by the ADHD-associated human dopamine D4 receptor variant D4.7 in prefrontal cortex. J. Physiol. 594:135-47. [PDF file] ***

12.            Xu Z, Jiang H, Zhong P, Yan Z, Chen SD, Feng J (2016) Direct conversion of human fibroblasts to induced serotonergic neurons. Molecular Psychiatry 21:62-70. [PDF file] ^^^

13.            Zhong P and Yan Z (2016) Distinct physiological effects of dopamine D4 receptors on prefrontal cortical pyramidal neurons and fast-spiking interneurons. Cerebral Cortex 26:180-91. [PDF file] ***

14.            Yuen EY, Wei J, Yan Z (2016) Estrogen in prefrontal cortex blocks stress-induced cognitive impairments in female rats. J. Steroid Biochem. & Mol. Biol. 160:221-6. [PDF file] (review) ***

15.            Duffney LJ, Zhong P, Wei J, Matas E, Cheng J, Qin L, Ma K, Dietz DM, Kajiwara Y, Buxbaum JD, Yan Z (2015) Autism-like deficits in Shank3-deficient mice are rescued by targeting actin regulators. Cell Reports 11:1400-1413. [PDF file] [supplemental materials] ***

16.            Jiang H, Xu Z, Zhong P, Ren Y, Liang G, Schilling HA, Hu Z, Zhang Y, Wang X, Chen S, Yan Z, Feng J (2015) Cell cycle and p53 gate the direct conversion of human fibroblasts to dopaminergic neurons. Nature Communications 6:10100. [PDF file] ^^^

17.            Wei J, Graziane NM, Gu Z, and Yan Z (2015) DISC1 protein regulates GABAA receptor trafficking and inhibitory synaptic transmission in cortical neurons. J. Biol. Chem. 290: 27680-7. [PDF file] ***

18.            Tang B, Luo D, Yang J, Xu XY, Zhu BL, Wang X, Yan Z, Chen GJ (2015) Modulation of AMPA receptor mediated current by nicotinic acetylcholine receptor in layer I neurons of rat prefrontal cortex. Scientific Reports 5:14099. [PDF file] !!!

19.            Hu Z, Pu J, Jiang H, Zhong P, Qiu J, Li F, Wang X, Zhang B, Yan Z, Feng J (2015) Generation of naivetropic induced pluripotent stem cells from Parkinson's disease patients for high efficiency genetic manipulation and disease modeling. Stem Cells Dev. 24:2591-604. [PDF file] ^^^

20.            Plattner F, Hayashi K, Hernandez A, Benavides DR, Tassin TC, Tan C, Day J, Fina MW, Yuen EY, Yan Z, Goldberg MS, Nairn AC, Greengard P, Nestler EJ, Taussig R, Nishi A, Houslay MD & Bibb JA (2015) The role of ventral striatal cAMP signaling in stress-induced behaviors. Nature Neuroscience 18:1094-100. [PDF file]***

21.            Cheng J, Xiong Z, Duffney LJ, Wei J, Liu AY, Liu S, Chen GJ, Yan Z (2014) Methylphenidate exerts dose-dependent effects on glutamate receptors and behaviors. Biol. Psychiatry 76:953-62. [PDF file] ***

22.            Yuen EY, Qin L, Wei J, Liu W, Liu A and Yan Z (2014) Synergistic regulation of glutamatergic transmission by serotonin and norepinephrine reuptake inhibitors in prefrontal cortical neurons. J. Biol. Chem. 289:25177-85 [PDF file] ***

23.            Wang Q, Xiao B, Cui S, Song H, Qian Y, Dong L, An H, Cui Y, Zhang W, He Y, Zhang J, Yang J, Zhang F, Hu G, Gong X, Yan Z, Zheng Y, Wang X (2014) Triptolide with multiple modes of action improves learning performance in the 5XFAD Alzheimer's disease mouse model. Disease Models & Mechanisms 7:1385-95. [PDF file] !!!

24.            Gu Z, Cheng J, Zhong P, Qin L, Liu W, Yan Z (2014) Ab selectively impairs mGluR7 modulation of NMDA signaling in basal forebrain cholinergic neurons: implication in Alzheimer's disease. J. Neurosci. 34:13614-13628. [PDF file] !!!

25.            Smith KR, Davenport EC, Wei J, Li X, Pathania M, Vaccaro V, Yan Z, Kittler JT (2014) GIT1 and βPIX link Rac1 signalling to GABAA receptor cluster stability and inhibitory synapse strength. Cell Reports 9:298-310. [PDF file] ###

26.            Plattner F, Hernandez A, Kistler TM, Pozo K, Zhong P, Yuen EY, Tan C, Hawasli AH, Cooke SF, Nishi A, Guo A, Weiderhold T, Yan Z, Bibb JA (2014) Memory enhancement by targeting Cdk5 regulation of NR2B. Neuron 81:1070-83. [PDF file] ###

27.            Hayashi-Takagi A, Araki Y, Nakamura M, Vollrath B, Duron SG, Yan Z, Kasai H, Huganir RL, Campbell DA, Sawa A (2014) PAKs inhibitors ameliorate schizophrenia-associated dendritic spine deterioration in vitro and in vivo during late adolescence. Proc. Natl. Acad. Sci. USA 111:6461-6. [PDF file] ***

28.            Wei J, Graziane NM, Wang H, Zhong P, Wang Q, Liu W, Hayashi-Takagi A, Korth C, Sawa A, Brandon NJ, Yan Z (2014) Regulation of NMDA receptors by Disrupted-in-Schizophrenia-1 (DISC1). Biol. Psychiatry 75:414-24. [PDF file] ***

29.            Deng Y, Xiong Z, Chen P, Wei J, Chen SD, Yan Z (2014) β-Amyloid Impairs the regulation of NMDA receptors by Glycogen Synthase Kinase 3. Neurobiol. Aging 35:449-59. [PDF file] !!!

30.            Wei J, Yuen EY, Liu W, Li X, Zhong P, Karatsoreos IN, McEwen BS, Yan Z (2014) Estrogen protects against the detrimental effects of repeated stress on glutamatergic transmission and cognition. Molecular Psychiatry 19:588-98 [PDF file] ***

31.            Duffney LJ, Wei J, Cheng J, Liu W, Smith KR, Kittler JT, Yan Z (2013) Shank3 deficiency induces NMDA receptor hypofunction via an actin-dependent mechanism. J. Neurosci. 33:15767-78. [PDF file] ***

32.            Vithlani M, Hines RM, Zhong P, Terunuma M, Hines DJ, Revilla-Sanchez R, Jurd R, Haydon P, Rios M, Brandon N, Yan Z, Moss SJ (2013) Effects of BNDF on neurogenesis and depression depend upon phosphorylation of the GABAAR γ2 subunit. J. Neurosci. 33:15567-77. [PDF file] ***

33.            Cheng J, Liu W, Duffney LJ, Yan Z (2013) SNARE proteins are essential in the potentiation of NMDAR currents by group II metabotropic glutamate receptors. J. Physiol. 591:3935-47. [PDF file] ###

34.            Yuen EY, Zhong P, Li X, Wei J, Yan Z (2013) Restoration of glutamatergic transmission by dopamine D4 receptors in stressed animals. J. Biol. Chem. 288:26112-20. [PDF file] ***

35.            Chen GJ, Xiong Z, Yan Z (2013) Ab impairs nicotinic regulation of inhibitory synaptic transmission and interneuron excitability in prefrontal cortex. Molecular Neurodegeneration 8:3. [PDF file] !!!

36.            Yuen EY, Wei J, Liu W, Zhong P, Li X, Yan Z (2012) Repeated stress causes cognitive impairment by suppressing glutamate receptor expression and function in prefrontal cortex. Neuron 73:962-77. [PDF file]***

37.            Lee JB, Wei J, Liu W, Cheng J, Feng J, Yan Z (2012) Histone Deacetylase 6 gates the synaptic action of acute stress in prefrontal cortex. J. Physiology 90:1535-46. [PDF file] ***

38.            Yuen EY, Wei J, Zhong P, Yan Z (2012) Disrupted GABAAR trafficking and synaptic inhibition in a mouse model of Huntington's disease. Neurobiology of Disease 46:497-502. [PDF file]  !!!

39.            Jiang H, Ren Y, Yuen EY, Zhong P, Ghaedi M, Hu Z, Azabdaftari G, Nakaso K, Yan Z, Feng J (2012) Parkin controls dopamine utilization in human midbrain dopaminergic neurons. Nature Communications 3:668. [PDF file]  ^^^

40.            Gu Z, Liu W, Wei J, Yan Z (2012) Regulation of NMDA receptors by metabotropic glutamate receptor 7. J. Biol. Chem. 287:10265-75. (selected as "Papers of the Week") [PDF file] ***

41.            Yuen EY, Li X, Wei J, Horiguchi M, Meltzer HY, Yan Z (2012) The novel antipsychotic drug lurasidone enhances NMDA receptor-mediated synaptic responses. Mol. Pharm. 81:113-9. [PDF file]  ***

42.            Popoli M, Yan Z, McEwen BS, Sanacora G (2011) The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission. Nature Review Neuroscience 13:22-37. [PDF file] ***

43.            Yuen EY, Liu W, Karatsoreos IN, Ren Y, Feng J, McEwen BS, Yan Z (2011) Mechanisms for acute stress-induced enhancement of glutamatergic transmission and working memory. Mol. Psychiatry 16:156-70. [PDF file] [supporting information] (cover article)  ***

44.            Mandal M, Wei J, Zhong P, Chen J, Duffney LJ, Liu W, Yuen EY, Twelvetrees AE, Li S, Li XJ, Kittler JT, Yan Z (2011) Impaired AMPA receptor trafficking and function by mutant huntingtin. J. Biol. Chem. 286:33719-28. [PDF file]  !!!

45.            Zhong P, Yan Z (2011) Differential regulation of the excitability of prefrontal cortical fast-spiking interneurons and pyramidal neurons by serotonin and fluoxetine. PLoS One 6:e16970. [PDF file]   ***

46.            Yuen EY, Yan Z (2011) Cellular mechanisms for the dopamine D4 receptor-induced homeostatic regulation of AMPA receptors. J. Biol. Chem. 286:24957-65. [PDF file]   ***

47.            Wang D, Yuen EY, Zhou Y, Yan Z, Xiang YK (2011) Amyloid {beta} peptide1-42 induces internalization and degradation of β2 adrenergic receptor in prefrontal cortical neurons. J Biol Chem. 286:31852-63. [PDF file]   !!!

48.            Liu W, Dou F, Feng J, Yan Z (2011) RACK1 is involved in β-amyloid impairment of muscarinic regulation of GABAergic transmission. Neurobiol. Aging 32:1818-26. [PDF file]   !!!

49.            Yuen EY, Zhong P, Yan Z (2010) Homeostatic regulation of glutamatergic transmission by dopamine D4 receptors. Proc. Natl. Acad. Sci. USA  107:22308-13. [PDF file] [supporting information]   ***

50.            Wang Q, Charych EI, Pulito VL, Lee J, Graziane NM, Crozier RA, Revilla-Sanchez R, Kelly M, Dunlop AJ, Murdoch H, Taylor N, Xie Y, Pausch M, Hayashi-Takagi A, Bates B, Kariya K, Sawa A, Weinberg RJ, Moss SJ, Houslay MD, Yan Z, Brandon NJ (2011) The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function. Mol. Psychiatry 16:1006-23. [PDF file]  ***

51.            Liu W, Yuen EY, Yan Z (2010) The stress hormone corticosterone increases synaptic AMPA receptors via SGK regulation of the GDI-Rab4 complex. J. Biol. Chem. 285:6101-8. [PDF file]  ***

52.            Wei J, Liu W, Yan Z (2010) Regulation of AMPA receptor trafficking and function by glycogen synthase kinase 3. J. Biol. Chem. 285:26369-76. [PDF file]  ***

53.            Yuen EY, Liu W, Kafri T, van Praag H, Yan Z (2010) Regulation of AMPA receptor channels and synaptic plasticity by cofilin phosphatase Slingshot in cortical neurons.. J. Physiol. 588:2361-71. [PDF file]   ###

54.            Twelvetrees AE, Yuen EY, Arancibia-Carcamo IL, Rostaing P, Lumb MJ, Humbert S, Triller A, Saudou F, Yan Z, Kittler JT (2010) Delivery of GABAARs to synapses is mediated by HAP1-KIF5 and disrupted by mutant huntingtin. Neuron 65:53-65. [PDF file]  !!!

55.            Hayashi-Takagi A, Takaki M, Graziane NM, Seshadri S, Murdoch H, Dunlop AJ, Makino Y, Seshadri AJ, Ishizuka K, Srivastava DP, Xie Z, Baraban JM, Houslay MD, Tomoda T, Brandon NJ, Kamiya A, Yan Z, Penzes P, Sawa A (2010) Disrupted-in-Schizophrenia-1 (DISC1) regulates spines of the glutamate synapse via Rac1. Nat. Neurosci.  13:327-32. [PDF file]  ***

56.            Joiner MA, Lise MF, Yuen EY, Kam A, Hall DD, Malik ZA, Qian H, Chen Y, Ulrich JD, Burette AC, Weinberg RJ, Law PY, El-Husseini A, Yan Z, Hell JW (2010) Assembly of a β2-adrenergic receptor- GluR1 signaling complex for localized cAMP signaling. EMBO J 29:482-95. [PDF file]  ***

57.            Yuen EY, Liu W, Karatsoreos IN, Feng J, McEwen BS, Yan Z (2009) Acute stress enhances glutamatergic transmission in prefrontal cortex and facilitates working memory. Proc. Natl. Acad. Sci. USA 106:14075-9. [PDF file]  ***

58.            Mandal M and Yan Z (2009) PIP2 regulation of NMDA receptor channels in cortical neurons. Mol.  Pharm. 76:1349-59. [PDF file]  !!!

59.            Arancibia-Carcamo IL, Yuen EY, Muir J, Lumb MJ, Michels G, Smart TG, Yan Z, Kittler JT, Moss SJ (2009) Ubiquitin-dependent targeting of GABAARs for lysosomal degradation regulates the efficacy of neuronal inhibition. Proc. Natl. Acad. Sci. USA 106:17552-7. [PDF file]   ###

60.            Saliba RS, Gu Z, Yan Z, Moss SJ (2009) Blocking L-type voltage gated Ca2+ channels with dihydropyridines reduces gamma-aminobutyric acid type A receptor expression and synaptic inhibition. J Biol Chem. 284:32544-50.   ###

61.            Huang YH, Lin Y, Mu P, Marie H, Liu W, Yan Z, Sorg BA, Schluter O,  Zukin SR, Dong Y (2009) Exposure to cocaine generates nascent synapses in the nucleus accumbens. Neuron. 63:40-7. [PDF file]  ***

62.            Yuen EY, Yan Z (2009) Dopamine D4 receptors regulate AMPAR trafficking and glutamatergic transmission in GABAergic interneurons of prefrontal cortex. J. Neurosci. 29:550-62. [PDF file]  ***

63.            Gu Z, Liu W, Yan Z (2009) β-amyloid impairs AMPA receptor trafficking and function by reducing CaMKII synaptic distribution. J Biol Chem. 284:10639-49. [PDF file]  !!!

64.            Graziane N, Yuen EY, Yan Z (2009) Dopamine D4 receptors regulate GABAA receptor trafficking and function via an actin/cofilin/myosin-dependent mechanism. J. Biol. Chem. 284:8329-36. [PDF file]  ***

65.            Smith KR, McAinsh K, Chen G, Arancibia-Carcamo IL, Haucke V, Yan Z, Moss SJ, Kittler JT (2008) Regulation of inhibitory synaptic transmission by a conserved atypical AP2 interaction within GABAA receptor β and γ- subunits. Neuropharmacology 55:844-50.   ###

66.            Yuen EY, Jiang Q, Chen P, Feng J, Yan Z (2008) Activation of 5-HT2A/C receptors counteracts 5-HT1A regulation of NMDAR channels in pyramidal neurons of prefrontal cortex. J. Biol. Chem. 283:17194-204.  [PDF file]  ***

67.            Zhong P, Liu W, Gu Z, Yan Z (2008) Serotonin facilitates LTD induction in prefrontal cortex via p38 MAPK/Rab5-mediated enhancement of AMPA receptor internalization. J. Physiol. 586:4465-79. [PDF file]  ***

68.            Yuen EY, Ren Y, Yan Z (2008) PSD-95 and calcineurin control the sensitivity of NMDA receptors to calpain cleavage in cortical neurons. Mol. Pharmacol. 74:360-370. [PDF file]  

69.            Zhong P, Yuen EY, Yan Z (2008) Modulation of neuronal excitability by serotonin-NMDA interactions in prefrontal cortex. Mol. and Cell. Neurosci. 38:290-9.[PDF file]  ***

70.            Kittler JT, Chen G, Kukhtina V, Vahedi-Faridi A, Gu Z, Tretter V, Smith K, McAinsh K, Arancibia-Carcamo L, Saenger W, Haucke V, Yan Z, Moss SJ (2008) Regulation of inhibitory synaptic transmission by GABAA receptor γ2 subunit specific phospho-dependent binding of a YECL motif to the clathrin adaptor AP2. Proc. Natl. Acad. Sci. USA 105:3616-21. [PDF file]   ###

71.            Chen G, Chen P, Tan H, Ma D, Dou F, Feng J, Yan Z (2008) Regulation of the NMDA receptor-mediated synaptic response by acetylcholinesterase inhibitors and its impairment in an animal model of Alzheimer's disease. Neurobiol. Aging 29:1795-804. [PDF file]  !!! 

72.            Chen P, Gu Z, Liu W, Yan Z (2007) Glycogen synthase kinase 3 regulates NMDA receptor channel trafficking and function in cortical neurons. Mol. Pharm. 72:40-51. [PDF file]  !!!

73.            Benavides DR, Quinn JJ, Zhong P, Hawasli AH, Kansy JW, DiLeone R, Yan Z, Taylor JR, Bibb JA (2007) Cyclin-dependent protein kinase 5 controls cocaine responses, motivation for reward, and striatal neuron excitability. J. Neurosci. 27:12967-76. [PDF file]  ***

74.            Yuen EY, Liu W, Yan Z (2007) The phosphorylation state of GluR1 subunits determines the susceptibility of AMPA receptors to calpain cleavage. J. Biol. Chem. 282:16434-40. [PDF file]  

75.            Yuen EY, Gu Z, Yan Z (2007) Calpain regulation of AMPA receptor channels in cortical pyramidal neurons. J. Physiol. 580:241-54. [PDF file]  ^^^

76.            Gu Z, Jiang Q, Yan Z (2007) RGS4 modulates serotonin signaling in prefrontal cortex and links to serotonin dysfunction in a rat model of schizophrenia. Mol. Pharmacol. 71:1030-9. [PDF file]  ***

77.            Kastning K, Kukhtina V, Kittler JT, Chen G, Pechstein A, Enders S, Lee SH, Sheng M, Yan Z, Haucke V (2007) Molecular determinants for the interaction between AMPA receptors and the clathrin adaptor complex AP-2. Proc. Natl. Acad. Sci. USA 104:2991-6. [PDF file]   ###

78.            Liu W, Yuen EY, Allen PB, Feng J, Greengard P, Yan Z (2006) Adrenergic modulation of NMDA receptors in prefrontal cortex is differentially regulated by RGS proteins and spinophilin. Proc. Natl. Acad. Sci. USA 103:18338-43. [PDF file]  ***

79.            Allen PB, Zachariou V, Svenningsson P, Lepore AC, Centonze D, Costa C, Rossi S, Bender G, Chen G, Feng J, Snyder GL, Bernardi G, Nestler EJ, Yan Z, Calabresi P, Greengard P (2006) Distinct roles for spinophilin and neurabin in dopamine-mediated plasticity. Neuroscience 140:897-911. [PDF file]  ***

80.            Jiang Q, Yan Z, Feng J (2006) Neurotrophic factors protect against rotenone toxicity on dopaminergic neurons through a microtubule-dependent mechanism. J. Biol. Chem. 281:29231-400. [PDF file]  !!!

81.            Jiang Q, Yan Z, Feng J (2006) Activation of group III metabotropic glutamate receptors attenuates rotenone toxicity on dopaminergic neurons through a microtubule-dependent mechanism. J. Neurosci. 26:4318-28. [PDF file]  !!!

82.            Chen G, Kittler JT, Moss SJ, Yan Z (2006) Dopamine D3 receptors regulate GABA(A) receptor function through a phospho-dependent endocytosis mechanism in nucleus accumbens. J. Neurosci. 26:2511-9. [PDF file]  ***

83.            Gu Z, Jiang Q, Yuen EY, Yan Z (2006) Activation of dopamine D4 receptors induces synaptic translocation of CaMKII in cultured prefrontal cortical neurons. Mol. Pharmacol.  69:813-22. [PDF file] ***

84.            Wang X, Gu Z, Zhong P, Chen G, Feng J, Yan Z (2006) Aberrant regulation of NMDAR functions by dopamine D4 receptors in rats after phencyclidine exposure. Mol. and Cell. Neurosci.  31:15-25. [PDF file]  ***

85.            Yuen EY, Jiang Q, Chen P, Gu Z, Feng J, Yan Z (2005) Serotonin 5-HT1A receptors regulate NMDA receptor channels through a microtubule-dependent mechanism. J. Neurosci. 25: 5488-501. [PDF file]  ***

86.            Kittler JT, Chen G, Honing S, Bogdanov Y, McAinsh K, Arancibia-Carcamo IL, Jovanovic JN, Pangalos MN, Haucke V, Yan Z and Moss SJ (2005) Phospho-dependent binding of the clathrin AP2 adaptor complex to GABA(A) receptors regulates the efficacy of inhibitory synaptic transmission. Proc. Natl. Acad. Sci. USA 102:14871-6. [PDF file]   ###

87.            Gu Z, Jiang Q, Fu AKY, Ip NY, Yan Z (2005) Regulation of NMDA receptors by neuregulin signaling in prefrontal cortex. J. Neurosci. 25: 4974-84. [PDF file]  ***

88.            Yuen EY, Jiang Q, Feng J, Yan Z (2005) Microtubule regulation of NMDA receptor channels in neurons. J. Biol. Chem. 280:29420-7. [PDF file]   ###

89.            Wu HY, Yuen EY, Lu YF, Matsushita M, Matsui H, Yan Z, Tomizawa K (2005) Regulation of NMDA receptors by calpain in cortical neurons. J. Biol. Chem. 280: 21588-93. [PDF file] 

90.            Chen P, Yan Z (2005) Corticotropin-releasing factor in brain function. In: Handbook of Neurochemistry and Molecular Neurobiology (3rd Edition), (Editor-in-Chief: Abel Lajtha) Kluwer Academic/Plenum Publishers, New York , NY. ***

91.            Tyszkiewicz JP, Yan Z (2005) β-Amyloid peptides impair PKC-dependent functions of metabotropic glutamate receptors in prefrontal cortical neurons. J. Neurophysiol. 93: 3102-11. [PDF file]  !!!

92.            Gu Z and Yan Z (2004) Bi-directional regulation of CaMKII activity by dopamine D4 receptors in prefrontal cortex. Mol. Pharmacol. 66: 948-55. [PDF file]  ***

93.            Zhong P and Yan Z (2004) Chronic antidepressant treatment alters the serotonergic regulation of GABA transmission in prefrontal cortical pyramidal neurons. Neurosci. 129: 65-73. [PDF file]  ***

94.            Tan H, Zhong P, Yan Z (2004) Corticotropin-releasing factor and acute stress prolongs serotonergic regulation of GABA transmission in prefrontal cortical pyramidal neurons. J. Neurosci. 24: 5000-8. [PDF file]  ***

95.            Yan Z and Feng J (2004) Alzheimer's disease: interactions between cholinergic functions and β-amyloid. Current Alzheimer Research (review) 1: 241-8. [PDF file]  !!!

96.            Chen G, Greengard P, Yan Z (2004) Potentiation of NMDA receptor currents by dopamine D1 receptors in prefrontal cortex. Proc. Natl. Acad. Sci. USA 101: 2596-600. [PDF file]  ***

97.            Tyszkiewicz JP, Gu Z, Wang X, Cai X, Yan Z (2004) Group II metabotropic glutamate receptors enhance NMDA receptor currents via a protein kinase C-dependent mechanism in pyramidal neurons of rat prefrontal cortex. J. Physiology (London) 554: 765-77. [PDF file]  ***

98.            Wang X, Zhong P, Gu Z, Yan Z (2003) Regulation of NMDA receptors by dopamine D4 signaling in prefrontal cortex. J. Neurosci. 23: 9852-61. [PDF file]  ***

99.            Zhong P, Gu Z, Wang X, Jiang H, Feng J, Yan Z (2003) Impaired modulation of GABAergic transmission by muscarinic receptors in a mouse transgenic model of Alzheimer's disease. J. Biol. Chem. 278: 26888-96. [PDF file]  !!!

100.         Davila V, Yan Z, Craciun LC, Logothetis D, Sulzer D (2003) D3 dopamine autoreceptors do not activate GIRK channel currents in substantia nigra dopamine neurons. J. Neurosci. 23: 5693-7.  ***

101.         Gu Z, Zhong P, Yan Z (2003) Activation of muscarinic receptors inhibits β-amyloid peptide - induced signaling in cortical slices. J. Biol. Chem. 278: 17546-56. [PDF file] !!!

102.         Ma X, Zhong P, Gu Z, Feng J, Yan Z (2003) Muscarinic potentiation of GABAA receptor currents is gated by insulin signaling in the prefrontal cortex. J. Neurosci. 23: 1159-68. [PDF file]  !!!

103.         Wang X, Zhong P, Yan Z (2002) Dopamine D4 receptors modulate GABAergic signaling in pyramidal neurons of prefrontal cortex. J. Neurosci.22: 9185-93. [PDF file] ***

104.         Cai X, Gu Z, Zhong P, Ren Y, Yan Z (2002) Serotonin 5-HT(1A) receptors regulate AMPA receptor channels through inhibiting CaMKII in prefrontal cortical pyramidal neurons. J. Biol. Chem. 277: 36553-62. [PDF file]  ***

105.         Yan Z (2002) Regulation of GABAergic inhibition by serotonin signaling in prefrontal cortex: molecular mechanisms and functional implications. Molecular Neurobiology (review) 26: 203-16. [PDF file]  ***

106.         Cai X, Flores-Hernandez J, Feng J, Yan Z (2002) Activity-dependent bi-directional regulation of GABAA receptor channels by serotonin 5-HT4 receptors in pyramidal neurons of the prefrontal cortex. J. Physiology (London) 540: 743-59. [PDF file]  ***

107.         Yan Z, Chi P, Bibb JA, Ryan TA, Greengard P (2002) Roscovitine: a novel regulator of P/Q-type calcium channels and transmitter release in central neurons. J. Physiology (London) 540: 761-70.

108.         Feng J, Cai X, Zhao J, Yan Z (2001) 5-HT2 receptors modulate GABAA receptor channels through activation of anchored protein kinase C in prefrontal cortical neurons. J. Neurosci. 21: 6502-11. [PDF file] ***

109.         Liu F, Ma X, Ule J, Nishi A, Bibb JA, DeMaggio AJ, Yan Z, Nairn AC, Greengard P (2001) Regulation of cyclin dependent kinase 5 and casein kinase I by metabotropic glutamate receptors. Proc. Natl. Acad. Sci. USA 98: 11062-8. ***

110.         Yan Z, Flores-Hernandez J, Surmeier DJ (2001) Coordinated expression of muscarinic receptor mRNAs in striatal medium spiny neurons. Neuroscience 103: 1017-24.  !!!

111.         Bibb JA, Chen J, Taylor JR, Svenningsson P, Nishi A, Snyder GL, Yan Z, Sagawa ZK, Ouimet CC, Nairn AC, Nestler EJ, Greengard P (2001) Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5. Nature 410: 376-80.  ***

112.         Bibb JA, Yan Z, Svenningsson P, Snyder GL, Pieribone VA, Nairn AC, Messer A, Greengard P (2000) Severe deficiencies in dopamine signaling in presymptomatic Huntington's disease mice. Proc. Natl. Acad. Sci. USA 97: 6809-14. [PDF file]  !!!

113.         Feng J, Yan Z, Ferreira AB, Tomizawa K, Liauw JA, Zhuo M, Allen PB, Ouimet CC, Greengard P (2000) Regulation of the formation and function of dendritic spines by spinophilin. Proc. Natl. Acad. Sci. USA 97: 9287-92.  [PDF file] ***

114.         Flores-Hernandez J, Hernandez S, Snyder GL, Yan Z, Fienberg AA, Moss SJ, Greengard P, Surmeier DJ (2000) D1 dopamine receptor activation reduces GABAA receptor currents in neostriatal neurons through a PKA/DARPP-32 /PP-1 signaling cascade. J. Neurophysiology 83: 2996-3004.  ***

115.         Yan Z, Hsieh-Wilson L, Feng J, Tomizawa K, Allen PB, Fienberg AA, Nairn AC, Greengard P (1999) Protein phosphatase 1 modulation of neostriatal AMPA channels: regulation by DARPP-32 and spinophilin. Nature Neuroscience 2: 13-17. [PDF file] ***

116.         Yan Z, Feng J, Fienberg AA, Greengard P (1999) D2 dopamine receptors induce MAPK and CREB phosphorylation in neurons. Proc. Natl. Acad. Sci. USA 96: 11607-12.  [PDF file] ***

117.         Bibb JA, Snyder GL, Nishi A, Yan Z, Meijer L, Fienberg AA et al. (1999) Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons. Nature 402: 669-71.  [PDF file] ***

118.         Stwart A, Yan Z, Surmeier DJ, Foehring R (1999) Muscarine modulates Ca2+ currents in rat sensorymotor pyramidal cells via two distinct pathways. J. Neurophysiol. 81: 72-84.  !!!

119.         Mermelstein PG, Song WJ, Tkatch T, Yan Z, Surmeier DJ (1998) Inwardly rectifying potassium (IRK) currents are correlated with IRK subunit expression in rat nucleus accumbens medium spiny neurons. J. Neurosci. 18: 6650-61.  ###

120.         Chen Q, Veenman L, Knopp K, Yan Z, Medina L, Song WJ, Surmeier DJ, Reiner A (1998) Evidence for the preferential localization of GluR1 subunits of AMPA receptors to the dendritic spines of medium spiny neurons in rat striatum. Neuroscience  83: 749-61.  ###

121.         Yan Z and Surmeier DJ (1997) D5 dopamine receptors enhance Zn2+-sensitive GABAA currents in striatal cholinergic interneurons through a protein kinase A/protein phosphatase 1 cascade. Neuron 19: 1115-26. [PDF file] ***

122.         Yan Z, Song WJ, Surmeier DJ (1997) D2 dopamine receptors reduce N-type Ca2+ currents in rat neostriatal cholinergic interneurons through a membrane-delimited, protein kinase C-insensitive pathway. J. Neurophysiol. 77: 1003-15. [PDF file] ***

123.         Surmeier DJ, Song WJ, Yan Z (1996) Coordinated expression of dopamine receptors in neostriatal medium spiny neurons. J. Neurosci. 16: 6579-91. [PDF file] ***

124.         Yan Z and Surmeier DJ (1996) Muscarinic (m2/m4) receptors reduce N- and P-type Ca2+ currents in rat neostriatal cholinergic interneurons through a fast, membrane-delimited, G-protein pathway. J. Neurosci. 16: 2592-604.  [PDF file] !!!


***:         Papers related to mental health and disorders;

!!!          Papers related to neurodegenerative diseases;

###:         Papers related to basic neurobiological mechanisms;

 ^^^:         Papers related to stem cells.