Zhen
Yan, Ph.D.
Selected
Publications:
1.
Yang
G, Ren Y, Zhong P, Patel PJ, Chen XQ, Wan L, Lee YH, Saleem K, Feng J, Yan Z (2025) Histone demethylase PHF2 regulates
inflammatory genes in Alzheimer's disease. Molecular Psychiatry (online
ahead of print). [PDF file] !!!
2.
Saleem K, Xiao Z, Zhu B, Ren Y, Yan Z, Feng J (2025)
Elevated SGK1 increases tau phosphorylation and microtubule instability in
Alzheimer's patient-derived cortical
neurons. Molecular Psychiatry (in
press). !!!
3.
Lin
CH, Ren Y, Tam KW, Conrow-Graham M, Yan Z (2025) Synaptic deficits in Adnp-mutant mice are ameliorated by histone demethylase
LSD1 inhibition. Autism Research 18(7):1342-1355. [PDF file] ***
4.
Patel PJ, Yan Z (2025) Epigenomic aberrations of histone methylation in
prefrontal cortex of humans with mild cognitive impairment and Alzheimer's
disease. medRxiv [Preprint]. doi: 10.1101/2025.07.17.25331659. !!!
5.
Li P, Men S, Patel PJ, Saleem K, Zhong P, Tam KW, Feng J, Yan Z (2025) Cognitive and synaptic and impairment
induced by deficiency of autism risk
gene Smarcc2 and its rescue by histone deacetylase inhibition. bioRxiv [Preprint]. doi:
10.1101/2025.05.29.656867. ***
6.
Jiang H, Xiao Z, Saleem K, Zhong
P, Li L, Chhetri G, Li P, Jiang Z, Yan Z, Feng J (2025) Generation of
human iPSC-derived cortical neurons expressing the six tau isoforms. J.
Alzheimer's Disease 105(4):1341-1354.
[PDF file] !!!
7.
Wan L,
Zhong P, Li P, Ren Y, Wang W, Yu M, Feng HY, Yan Z (2025) CRISPR-based
epigenomic editing of Gad1 expression improves synaptic inhibition and
cognitive behavior in a Tauopathy mouse model. Neurobiology of Disease 206:106826.
[PDF file] !!!
8.
Yan
Z
(2024) Targeting epigenetic enzymes for autism treatment. Trends in
Pharmacological Sciences (review) 45(9):764-767. [PDF file] ***
9.
Zhong
P, Cao Q, Yan Z (2024) Distinct and convergent alterations of entorhinal
cortical circuits in two mouse models for Alzheimer's disease and related disorders. J.
Alzheimer's
Disease 98(3):1121-1131. [PDF file] !!!
10.
Carballo
LH, Li P, Senek R, Yan Z (2024) Systemic HDAC inhibition ameliorates the
aberrant responses to acute stress in socially isolated male mice. J.
Physiology 602(9):2047-2060. [PDF file] ***
11.
Wan L, Yang G, Yan Z (2024) Identification of
a molecular network regulated by multiple ASD high risk genes. Human
Molecular Genetics 33(13):1176-1185. [PDF file] ***
12.
Williams
JB, Cao Q, Wang W, Lee YH, Qin L, Zhong P, Ren Y, Ma K, Yan Z (2023) Inhibition
of histone methyltransferase Smyd3
rescues NMDAR and cognitive deficits in a tauopathy mouse model. Nature
Communications 14:91. [PDF file] !!!
13.
Li P and Yan Z (2023) An epigenetic mechanism
of social isolation stress in adolescent female mice. Neurobiology of
Stress 29:100601. [PDF file] ***
14.
Cao
Q, Kumar M, Frazier A, Williams JB, Zhao S, Yan Z (2023)
Longitudinal characterization of behavioral, morphological and
transcriptomic changes in a tauopathy mouse model. Aging [PDF file] !!!
15.
Patel
PJ, Ren Y, Yan Z (2023) Epigenomic
analysis of Alzheimer's disease brains reveals
diminished CTCF binding on genes involved in synaptic organization. Neurobiology
of Disease 184:106192.
[PDF file] !!!
16.
Zhu B, Fisher E, Li L, Zhong P, Yan Z, Feng J
(2023) PTBP2 attenuation facilitates fibroblast to neuron conversion by
promoting alternative splicing of neuronal genes. Stem Cell Reports
18(11):2268-2282.
[PDF file] ^^^
17.
Pu J, Lin L, Jiang H, Hu Z, Li H, Yan Z, Zhang
B, Feng J (2023) Parkin maintains robust pacemaking
in human iPSC-derived A9 dopaminergic neurons. Movement Disorder 38(7):1273-1281. [PDF file] ^^^
18.
Rapanelli M, Wang W, Hurley E, Feltri
ML, Pittenger C, Frick LR, Yan Z (2023) Cholinergic neurons in the basal
forebrain are involved in behavioral abnormalities associated with Cul3
deficiency: role of prefrontal cortex projections in cognitive deficits. Translational
Psychiatry 13(1):22. [PDF file] ***
19.
Yan Z
(2023) A physiological cause to empathy deficits in a mouse model of FTD. Neuron
11(6):757-758. (preview) [PDF file] ***
20.
Conrow-Graham
M, Williams JB, Martin J, Zhong P, Cao
Q, Rein B, Yan Z (2022) A Convergent mechanism of high risk factors ADNP and POGZ in neurodevelopmental
disorders. Brain 145: 3250-3263.
[PDF file] ***
21.
Wang
ZJ, Shwani T, Liu J, Zhong P, Yang F, Schatz K, Zhang
F, Pralle A, Yan Z (2022) Molecular
and cellular mechanisms for differential effects of chronic social isolation
stress in males and females. Molecular Psychiatry 27(7):3056-3068. [PDF file] ***
22.
Li H,
Jiang H, Li H, Li L, Yan Z, Feng J (2022) Generation of human A9 dopaminergic pacemakers from induced pluripotent
stem cells. Molecular Psychiatry 27(11):4407-4418. [PDF file] ^^^
23. Wang W, Tan T, Cao Q, Zhang F, Rein B, Duan WM, Yan Z (2022) Histone Deacetylase Inhibition Restores Behavioral and Synaptic Function in a Mouse Model of 16p11.2 Deletion. Int J Neuropsychopharmacol. 25(10):877-889. [PDF file] ***
24.
Sanacora G, Yan Z, Popoli M (2022) The stressed
synapse 2.0: Pathophysiological mechanisms in stress-related neuropsychiatric
disorders. Nature Reviews Neuroscience 23:86-103. [PDF file] ***
25.
Zhong P, Cao Q, Yan
Z (2022) Selective impairment of circuits between prefrontal cortex
glutamatergic neurons and basal forebrain cholinergic neurons in a tauopathy
mouse model. Cerebral Cortex 32(24):5569-5579. [PDF file] !!!
26.
Rapanelli M, Williams JB, Ma K, Yang F, Zhong P,
Patel R, Kumar M, Qin L, Rein B, Wang ZJ, Kassim B, Javidfar
B, Couto L, Akbarian S, Yan Z (2022)
Targeting histone demethylase LSD1 for treatment of deficits in autism mouse
models. Molecular Psychiatry 27(8):3355-3366. [PDF file] ***
27.
Rein
B, Conrow-Graham M, Frazier A, Cao Q, Yan
Z (2022) Inhibition of histone deacetylase 5 ameliorates abnormalities in 16p11.2 duplication mouse model.
Neuropharmacology 204:108893. [PDF file] ***
28.
Qin
L, Ma K, Yan Z (2022) Rescue
of histone hypoacetylation and social deficits by ketogenic diet in a Shank3
mouse model of autism. Neuropsychopharmacology 47(6):1271-1279. [PDF file] ***
29.
Yan Z
and Rein B (2022) Mechanisms of synaptic transmission dysregulation in the
prefrontal cortex: pathophysiological implications. Molecular
Psychiatry (review) 27(1):445-465. [PDF file] ***
30.
Qin
L, Williams JB, Tan T, Liu T, Cao Q, Ma K, Yan Z (2021) Deficiency of autism risk factor Ash1l in prefrontal cortex induces
epigenetic aberrations and seizures. Nature Communications
12:6589. [PDF file] ***
31.
Wang W, Cao Q, Tan T, Yang F, Williams JB, Yan Z
(2021) Epigenetic treatment of
behavioral and physiological deficits in a tauopathy mouse model. Aging Cell 20(10):e13456. [PDF file]
!!!
32.
William
JB, Cao Q, Yan
Z (2021) Transcriptomic analysis of human brains with Alzheimer's disease
reveals the altered expression of synaptic genes linked to cognitive deficits.
Brain Communications 3(3):fcab123 [PDF file] !!!
33.
Tan
T, Wang W, Liu T, Zhong P, Conrow-Graham M, Tian X, Yan Z (2021) Neural circuits and activity dynamics underlying sex-specific effects of
chronic social isolation stress. Cell
Reports 34:108874. [PDF file] ***
34.
Catlin J, Marziali L, Rein B, Yan Z, Feltri
LM, Schaner-Tooley CE (2021) Age-related neurodegeneration and cognitive
impairments of NRMT1 knockout mice are preceded by misregulation
of RB and abnormal neural stem cell development. Cell Death and Disease
12:1014. !!!
35.
Wang
ZJ, Rein B, Zhong P, Williams JB, Cao Q, Yang F, Zhang F, Ma K, Yan Z (2021) Autism risk gene Kmt5b deficiency in prefrontal cortex induces synaptic
dysfunction and social deficits via alterations of DNA repair and gene
transcription. Neuropsychopharmacology 46:1617-1626. [PDF file] ***
36.
Li B,
Jiang H, Li H, Zhang B, Slaughter M, Yan Z, Feng J (2021) Direct
conversion of adult human retinal pigmented epithelium cells to neurons with
photoreceptor properties. Exp Biol Med 246(2):240-248. ^^^
37.
Rein
B, Tan T, Yang F, Wang W, Williams J, Zhang F, Mills A, Yan Z (2021) Reversal of
synaptic and behavioral deficits in a 16p11.2 duplication mouse model via
restoration of the GABA synapse regulator Npas4.
Molecular Psychiatry 26:1967-1979. [PDF file] ***
38.
Zhang
F, Rein B, Zhong P, Shwani T, Conrow-Graham M, Wang
ZJ, Yan Z (2021) Synergistic
inhibition of histone modifiers produces therapeutic effects in adult Shank3-deficient mice. Translational
Psychiatry 11(1):99. [PDF file] ***
39.
Wei J, Cheng J, Waddell NJ, Wang ZJ, Pang X, Cao Q,
Liu A, Chitaman JM, Abreu K, Jasrotia
RS, Duffney LJ, Zhang J, Dietz DM, Feng J, Yan
Z (2021) DNA methyltransferase 3A is involved in the sustained effects of
chronic stress on synaptic functions and behaviors. Cerebral Cortex. 31:1998-2012. [PDF file]
***
40.
Rapanelli
M, Tan T, Wang W, Wang X, Zhong P, Wang ZJ, Frick L, Qin L, Ma K, Qu J, Yan
Z (2021) Behavioral, circuitry and molecular aberrations by region-specific
deficiency of the high-risk autism gene Cul3. Molecular Psychiatry
26:1491-1504.
[PDF file]
41.
Cao
Q, Wang W, Williams J, Yang F, Wang ZJ, Yan
Z (2020) Targeting histone K4 trimethylation for treatment of cognitive and
synaptic deficits in mouse models of Alzheimer's disease. Science Advances 6(50):eabc8096. [PDF file] DOI: 10.1126/sciadv.abc8096
!!!
42.
Rein
B, Ma K, Yan Z (2020) A standardized
social preference protocol for measuring social deficits in mouse models of
autism. Nature Protocols 15:3464-3477. [PDF file] DOI: 10.1038/s41596-020-0382-9
***
43.
Rein
B and Yan Z (2020) 16p11.2 copy number variations and
neurodevelopmental disorders. Trends
in Neuroscience 43(11):886-901. (review) [PDF file] DOI: 10.1016/j.tins.2020.09.001
***
44.
Lepack
AE, Werner CT, Stewart AF, Fulton SL, Zhong P, Farrelly LA, Smith ACW,
Ramakrishnan A, Lyu Y, Bastle RM, Martin JA, Mitra S, O'Connor RM, Wang ZJ,
Molina H, Turecki G, Shen L, Yan Z,
Calipari ES, Dietz DM, Kenny PJ, Maze I (2020) Dopaminylation
of histone H3 in ventral tegmental area regulates cocaine seeking. Science
368:197-201. DOI: 10.1126/science.aaw8806 ***
45.
Zhong P, Qin L, Yan Z (2020) Dopamine differentially
regulates response dynamics of PFC principal neurons and interneurons to
optogenetic stimulation of VTA inputs. Cerebral Cortex 30:4402-4409. DOI: 10.1093/cercor/bhaa027 ***
46.
Jin
J, Bhatti DL, Lee KW, Medrihan L, Cheng J, Wei J,
Zhong P, Yan
Z, Kooiker C, Song C, Ahn
JH, Obermair GJ, Lee A, Gresack
J, Greengard P, Kim Y (2020) Ahnak scaffolds
p11/Anxa2 complex and L-type voltage-gated calcium channel and modulates
depressive behavior. Mol. Psychiatry 25:1035-1049. DOI: 10.1038/s41380-019-0371-y
***
47.
Wang ZJ, Zhong P, Ma K, Seo JS, Yang F, Hu Z, Zhang F, Lin
L, Wang J, Liu T, Matas E, Greengard P, Yan Z (2020) Amelioration of autism-like
social deficits by targeting histone methyltransferases EHMT1/2 in Shank3-deficient
mice. Mol. Psychiatry 25:2517-2533. [PDF file] DOI: 10.1038/s41380-019-0351-2
***
48.
Zheng
Y, Liu A, Wang ZJ, Cao Q, Wang W, Lin L, Ma K, Zhang F, Wei J, Matas E, Cheng
J, Chen GJ, Wang X, Yan Z (2019) Inhibition of EHMT1/2 rescues synaptic
and cognitive functions for Alzheimer's disease. Brain 142:787-807.
[PDF
file] DOI: 10.1093/brain/awy354 !!!
49.
Martin JA, Werner CT, Mitra S, Zhong P, Wang ZJ, Gobira PH, Stewart AF, Zhang J, Erias K, Siemian JN,
Hagarty D, Mueller LE, Neve RL, Li JX, Chandra R, Dietz KC, Lobo MK, Gancarz
AM, Yan Z, Dietz DM (2019) A novel role for the actin-binding protein drebrin in regulating opiate addiction. Nature
Communications 10:4140. DOI: 10.1038/s41467-019-12122-8 ***
50.
Qin L, Ma K, Yan Z (2019) Chemogenetic
activation of prefrontal cortex in Shank3-deficient mice ameliorates
social deficits, NMDAR hypofunction and Sgk2 downregulation. iScience 17:24-35. DOI: 10.1016/j.isci.2019.06.014
***
51.
Rein B, Yan Z,
Wang ZJ (2019) Diminished social interaction incentive contributes to social
deficits in mouse models of autism spectrum disorder. Genes Brain Behav. 19(1):e12610. DOI: 10.1111/gbb.12610 ***
52.
Lin L, Liu A, Li HQ,
Feng J, Yan Z (2019) Inhibition of histone
methyltransferases EHMT1/2 reverses b amyloid-induced loss of AMPAR currents in
human stem cell-derived cortical neurons. J. Alzheimer's Disease 70:1175-1185.
53.
Zhu BL, Long Y, Luo
W, Yan Z, Lai YJ, Zhao LG, Zhou WH, Wang YJ, Shen LL, Liu L, Deng XJ,
Wang XF, Sun F, Chen GJ (2019) MMP13
inhibition rescues cognitive decline in Alzheimer transgenic mice via BACE1
regulation. Brain 142:176-192. DOI: 10.1093/brain/awy305 !!!
54.
Xiang XJ, Song L,
Deng XJ, Tang Y, Min Z, Luo B, Wen QX, Li KY, Chen J, Ma YL, Zhu BL, Yan Z,
Chen GJ (2019) Mitochondrial methionine sulfoxide reductase B2 links oxidative stress
to Alzheimer's disease-like pathology. Exp Neurol. 318:145-156.
DOI: 10.1016/j.expneurol.2019.05.006
!!!
55.
Lai YJ, Zhu BL, Sun
F, Luo D, Ma YL, Luo B, Tang J, Xiong MJ, Liu L, Long Y, Hu XT, He L, Deng XJ,
Zhang JH, Yang J, Yan Z, Chen GJ (2019) Estrogen receptor α
promotes Cav1.2 ubiquitination and degradation in neuronal cells and in APP/PS1
mice. Aging Cell 18:e12961. DOI: 10.1111/acel.12961
!!!
56.
Tan T, Wang W,
Williams J, Ma K, Cao Q, Yan Z
(2019) Stress exposure in dopamine D4 receptor knockout mice induces
schizophrenia-like behaviors via disruption of GABAergic transmission. Schizophrenia
Bulletin 45:1012-1023. DOI: 10.1093/schbul/sby163 ***
57.
Qin L, Ma K, Wang ZJ,
Hu Z, Matas E, Wei J, Yan Z (2018)
Social deficits in Shank3-deficient mouse models of autism are rescued
by histone deacetylase (HDAC) inhibition. Nature Neurosci.
21:564-575. [PDF file] DOI: 10.1038/s41593-018-0110-8 ***
58.
Ma K, Qin L, Matas M, Duffney LJ, Liu A, Yan Z (2018) Histone deacetylase
inhibitor MS-275 restores social and synaptic function in a Shank3-deficient mouse model of autism. Neuropsychopharmacology
43:1779-1788. DOI: 10.1038/s41386-018-0073-1 ***
59.
Wang W, Rein B, Tan T, Zhang F, Qin L, Yan
Z (2018) Chemogenetic activation of prefrontal
cortex rescues synaptic
and behavioral deficits in a mouse model of 16p11.2 deletion syndrome. J. Neurosci. 38:5939-5948. DOI: 10.1523/JNEUROSCI.0149-18.2018 ***
60.
Seo JS, Zhong P, Liu
A, Yan Z, Greengard P (2018) Elevation of p11 in lateral habenula mediates depression-like behavior. Molecular Psychiatry 23:1113-1119.
DOI: 10.1038/mp.2017.96 ***
61.
Tang Y, Min Z, Xiang
XJ, Liu L, Ma YL, Zhu BL, Song L, Tang J, Deng XJ, Yan Z, Chen GJ (2018) Estrogen-related
receptor alpha is involved in Alzheimer's disease-like pathology. Exp
Neurol. 305:89-96. DOI: 10.1016/j.expneurol.2018.04.003 !!!
62.
Wei J, Zhong P, Qin L, Tan T, Yan Z (2017) Chemicogenetic restoration of the prefrontal cortex to amygadala pathway ameliorates stress-induced deficits. Cerebral
Cortex 28:1980-1990. DOI: 10.1093/cercor/bhx104 ***
63.
Zhong P, Hu Z, Jiang
H, Yan Z, Feng J (2017) Dopamine
induces oscillatory activity in human midbrain neurons with Parkin mutations. Cell Reports 19:1033-1044. [PDF
file] DOI: 10.1016/j.celrep.2017.04.023 ^^^
64.
Seo JS, Wei J, Qin L,
Kim Y, Yan Z, Greengard P (2017)
Molecular and cellular basis for stress-induced depression. Molecular
Psychiatry 22:1440-1447. DOI: 10.1038/mp.2016.118 ***
65.
Cheng J, Liu A, Shi
MY, Yan Z (2017) Disrupted glutamatergic transmission in prefrontal
cortex contributes to behavioral abnormality in an animal model of ADHD. Neuropsychopharmacology
42:2096-2104. DOI: 10.1038/npp.2017.30 ***
66.
Yang J, Liu AY, Tang
B, Luo D, Lai YJ, Zhu BL, Wang XF, Yan Z,
Chen GJ (2017) Chronic nicotine differentially affects murine transcriptome
profiling in isolated cortical interneurons and pyramidal neurons. BMC
Genomics 18:194. DOI: 10.1186/s12864-017-3593-x !!!
67.
Yan Z, Kim E, Datta D, Lewis D, Soderling S (2016) Synaptic actin dysregulation,
a convergent mechanism of mental disorders? J. Neuroscience
36:11411-7. (review) DOI: 10.1523/JNEUROSCI.2360-16.2016 ***
68.
Qin L, Liu W, Ma K,
Wei J, Zhong P, Cho K, Yan Z (2016)
The ADHD-linked human dopamine D4 receptor variant D4.7 induces
over-suppression of NMDA receptor function in prefrontal cortex. Neurobiology
of Disease 95:194-203. DOI: 10.1016/j.nbd.2016.07.024 ***
69.
Deng Y, Wei J, Cheng
J, Zhong P, Xiong Z, Liu A, Lin L, Chen SD, Yan Z (2016) Partial amelioration of synaptic and
cognitive deficits by inhibiting cofilin dephosphorylation in an animal model
of Alzheimer's disease. J. Alzheimer's Disease 53:1419-32. DOI: 10.3233/JAD-160167 !!!
70.
Wei J, Xiong Z, Lee
JB, Cheng J, Duffney LJ, Matas E, Yan Z
(2016) Histone modification of Nedd4
ubiquitin ligase controls the loss of AMPA receptors and cognitive impairment
induced by repeated stress. J. Neurosci.
36:2119-30. DOI: 10.1523/JNEUROSCI.3056-15.2016 ***
71.
Zhong P, Liu W, Yan Z (2016) Aberrant regulation of
synchronous network activity by the ADHD-associated human dopamine D4 receptor
variant D4.7 in prefrontal cortex. J. Physiol. 594:135-47. DOI: 10.1113/JP271317 ***
72.
Xu Z, Jiang H, Zhong
P, Yan Z, Chen SD, Feng J (2016)
Direct conversion of human fibroblasts to induced serotonergic neurons. Molecular
Psychiatry 21:62-70. DOI: 10.1038/mp.2015.101 ^^^
73.
Zhong P and Yan Z (2016) Distinct physiological
effects of dopamine D4 receptors on prefrontal cortical pyramidal neurons and
fast-spiking interneurons. Cerebral Cortex 26:180-91. DOI: 10.1093/cercor/bhu190 ***
74.
Yuen EY, Wei J, Yan Z (2016) Estrogen in prefrontal
cortex blocks stress-induced cognitive impairments in female rats. J. Steroid Biochem. & Mol. Biol. 160:221-6. (review) DOI: 10.1016/j.jsbmb.2015.08.028 ***
75.
Duffney LJ, Zhong P,
Wei J, Matas E, Cheng J, Qin L, Ma K, Dietz DM, Kajiwara Y, Buxbaum JD, Yan Z (2015) Autism-like deficits in Shank3-deficient
mice are rescued by targeting actin regulators.
Cell
Reports 11:1400-1413. DOI: 10.1016/j.celrep.2015.04.064 ***
76.
Jiang H, Xu Z, Zhong
P, Ren Y, Liang G, Schilling HA, Hu Z, Zhang Y, Wang X, Chen S, Yan Z, Feng J (2015) Cell cycle and p53
gate the direct conversion of human fibroblasts to dopaminergic neurons. Nature Communications 6:10100. DOI: 10.1038/ncomms10100 ^^^
77.
Wei J, Graziane NM, Gu Z, and Yan
Z (2015) DISC1 protein regulates GABAA receptor trafficking and
inhibitory synaptic transmission in cortical neurons. J. Biol. Chem. 290:
27680-7. DOI: 10.1074/jbc.M115.656173 ***
78.
Tang B, Luo D, Yang
J, Xu XY, Zhu BL, Wang X, Yan Z,
Chen GJ (2015) Modulation of AMPA receptor mediated current by nicotinic
acetylcholine receptor in layer I neurons of rat prefrontal cortex. Scientific
Reports 5:14099. DOI: 10.1038/srep14099 ###
79.
Hu Z, Pu J, Jiang H,
Zhong P, Qiu J, Li F, Wang X, Zhang B, Yan Z, Feng J (2015) Generation of naivetropic induced pluripotent
stem cells from Parkinson's disease patients for high efficiency genetic
manipulation and disease modeling. Stem Cells Dev. 24:2591-604. DOI: 10.1089/scd.2015.0079 ^^^
80.
Plattner F, Hayashi K,
Hernandez A, Benavides DR, Tassin TC, Tan C, Day J, Fina MW, Yuen EY, Yan Z, Goldberg MS, Nairn AC, Greengard
P, Nestler EJ, Taussig R, Nishi A, Houslay MD &
Bibb JA (2015) The role of ventral
striatal cAMP signaling in stress-induced behaviors. Nature
Neuroscience 18:1094-100. DOI: 10.1038/nn.4066 ***
81.
Cheng J, Xiong Z,
Duffney LJ, Wei J, Liu AY, Liu S, Chen GJ, Yan
Z (2014) Methylphenidate
exerts dose-dependent effects on glutamate receptors and behaviors. Biol.
Psychiatry 76:953-62. [PDF file] DOI: 10.1016/j.biopsych.2014.04.003
***
82.
Yuen EY, Qin L, Wei
J, Liu W, Liu A and Yan Z (2014)
Synergistic regulation of glutamatergic transmission by serotonin and
norepinephrine reuptake inhibitors in prefrontal cortical neurons. J.
Biol. Chem. 289:25177-85. DOI: 10.1074/jbc.M114.567610 ***
83.
Gu Z, Cheng J, Zhong
P, Qin L, Liu W, Yan Z (2014) Ab selectively
impairs mGluR7 modulation of NMDA signaling in basal forebrain cholinergic
neurons: implication in Alzheimer's disease. J. Neurosci.
34:13614-13628. [PDF file] DOI: 10.1523/JNEUROSCI.1204-14.2014
!!!
84.
Smith KR, Davenport
EC, Wei J, Li X, Pathania M, Vaccaro V, Yan Z, Kittler JT (2014) GIT1 and βPIX are essential for GABA(A) receptor synaptic
stability and inhibitory neurotransmission. Cell Reports 9:298-310. DOI: 10.1016/j.celrep.2014.08.061 ###
85.
Plattner F, Hernandez
A, Kistler TM, Pozo K, Zhong P, Yuen EY, Tan C, Hawasli
AH, Cooke SF, Nishi A, Guo A, Weiderhold T, Yan Z, Bibb JA (2014) Memory enhancement by targeting Cdk5
regulation of NR2B. Neuron 81:1070-83. DOI: 10.1016/j.neuron.2014.01.022 ###
86.
Hayashi-Takagi A,
Araki Y, Nakamura M, Vollrath B, Duron SG, Yan
Z, Kasai H, Huganir RL, Campbell DA, Sawa A
(2014) PAKs inhibitors ameliorate schizophrenia-associated dendritic spine
deterioration in vitro and in vivo during late adolescence. Proc. Natl.
Acad. Sci. USA 111:6461-6. DOI: 10.1073/pnas.1321109111 ***
87.
Wei J, Graziane NM, Wang H, Zhong P, Wang Q, Liu W, Hayashi-Takagi
A, Korth C, Sawa A, Brandon NJ, Yan Z (2014) Regulation of NMDA receptors by Disrupted-in-Schizophrenia-1
(DISC1). Biol. Psychiatry 75:414-24. DOI: 10.1016/j.biopsych.2013.06.009
***
88.
Wang Q, Xiao
B, Cui S, Song H, Qian Y, Dong L, An H, Cui Y, Zhang W, He Y, Zhang J, Yang J,
Zhang F, Hu G, Gong X, Yan Z, Zheng
Y, Wang X (2014) Triptolide treatment reduces Alzheimer's disease (AD)-like
pathology through inhibition of BACE1 in a transgenic mouse model of AD. Disease
Models & Mechanisms 7:1385-95. DOI: 10.1242/dmm.018218
89.
Deng Y, Xiong Z, Chen
P, Wei J, Chen SD, Yan Z (2014) β-Amyloid Impairs the regulation of
NMDA receptors by Glycogen Synthase Kinase 3. Neurobiol.
Aging 35:449-59. DOI: 10.1016/j.neurobiolaging.2013.08.031 !!!
90.
Wei J, Yuen EY, Liu W, Li X, Zhong P, Karatsoreos
IN, McEwen BS, Yan Z (2014) Estrogen
protects against the detrimental effects of repeated stress on glutamatergic
transmission and cognition. Molecular Psychiatry 19:588-98 [PDF file] DOI: 10.1038/mp.2013.83 ***
91.
Duffney LJ, Wei J,
Cheng J, Liu W, Smith KR, Kittler JT, Yan
Z (2013) Shank3 deficiency induces NMDA receptor hypofunction via an actin-dependent mechanism. J. Neurosci. 33:15767-78. [PDF file] DOI: 10.1523/JNEUROSCI.1175-13.2013
***
92.
Vithlani M, Hines RM, Zhong P, Terunuma
M, Hines DJ, Revilla-Sanchez R, Jurd R, Haydon P,
Rios M, Brandon N, Yan Z, Moss SJ (2013) The ability of BDNF to modify neurogenesis
and depressive-like behaviors is dependent upon phosphorylation of tyrosine
residues 365/367 in the GABA(A)-receptor γ2 subunit. J. Neurosci. 33:15567-77. DOI: 10.1523/JNEUROSCI.1845-13.2013 ***
93.
Cheng J, Liu W,
Duffney LJ, Yan Z (2013) SNARE
proteins are essential in the potentiation of NMDAR currents by group II
metabotropic glutamate receptors. J. Physiol. 591:3935-47.
DOI: 10.1113/jphysiol.2013.255075 ###
94.
Yuen EY, Zhong P, Li
X, Wei J, Yan Z (2013) Restoration
of glutamatergic transmission by dopamine D4 receptors in stressed
animals. J. Biol. Chem. 288:26112-20. DOI: 10.1074/jbc.M112.396648
***
95.
Chen GJ, Xiong Z, Yan Z (2013) Ab impairs nicotinic regulation of
inhibitory synaptic transmission and interneuron excitability in prefrontal
cortex. Molecular Neurodegeneration 8:3. DOI: 10.1186/1750-1326-8-3 !!!
96.
Yuen EY, Wei J, Liu
W, Zhong P, Li X, Yan Z (2012)
Repeated stress causes cognitive impairment by suppressing glutamate receptor
expression and function in prefrontal cortex. Neuron 73:962-77. [PDF file]. DOI: 10.1016/j.neuron.2011.12.033 ***
97.
Lee JB, Wei J, Liu W,
Cheng J, Feng J, Yan Z (2012)
Histone Deacetylase 6 gates the synaptic action of acute stress in prefrontal
cortex. J. Physiology 90:1535-46. DOI: 10.1113/jphysiol.2011.224907 ***
98.
Yuen EY, Wei J, Zhong
P, Yan Z (2012) Disrupted GABAAR
trafficking and synaptic inhibition in a mouse model of Huntington's disease. Neurobiology
of Disease 46:497-502. DOI: 10.1016/j.nbd.2012.02.015 !!!
99.
Jiang H, Ren Y, Yuen
EY, Zhong P, Ghaedi M, Hu Z, Azabdaftari
G, Nakaso K, Yan
Z, Feng J (2012) Parkin controls
dopamine utilization in human midbrain dopaminergic neurons. Nature Communications 3:668. DOI: 10.1038/ncomms1669
^^^
100.
Gu Z, Liu W, Wei J, Yan
Z (2012) Regulation of NMDA receptors by metabotropic glutamate receptor 7.
J.
Biol. Chem. 287:10265-75. DOI: 10.1074/jbc.M111.325175 ###
101.
Yuen EY, Li X, Wei J,
Horiguchi M, Meltzer HY, Yan Z (2012)
The novel antipsychotic drug lurasidone enhances NMDA receptor-mediated
synaptic responses. Mol. Pharm. 81:113-9. DOI: 10.1124/mol.111.076141 ***
102.
Popoli M, Yan Z, McEwen BS, Sanacora
G (2011) The stressed synapse: the
impact of stress and glucocorticoids on glutamate transmission. Nature
Reviews Neuroscience 13:22-37. (review) [PDF
file]
103. Yuen EY, Liu W, Karatsoreos IN, Ren Y, Feng J,
McEwen BS, Yan Z (2011) Mechanisms for acute stress-induced enhancement
of glutamatergic transmission and working memory. Mol. Psychiatry
16:156-70. DOI: 10.1038/mp.2010.50 (cover article) ***
104. Mandal M, Wei J, Zhong P, Chen J, Duffney LJ, Liu W, Yuen EY, Twelvetrees
AE, Li S, Li XJ, Kittler JT, Yan Z (2011)
Impaired AMPA receptor trafficking and function by mutant huntingtin. J.
Biol. Chem. 286:33719-28. DOI: 10.1074/jbc.M111.236521 !!!
105. Zhong P, Yan Z (2011)
Differential regulation of the excitability of prefrontal cortical fast-spiking
interneurons and pyramidal neurons by serotonin and fluoxetine. PLoS One 6:e16970. DOI: 10.1371/journal.pone.0016970 ###
106. Yuen EY, Yan Z (2011) Cellular
mechanisms for the dopamine D4 receptor-induced homeostatic regulation of AMPA
receptors. J. Biol. Chem. 286:24957-65. DOI: 10.1074/jbc.M111.221416 ###
107. Wang D, Yuen EY, Zhou Y, Yan
Z, Xiang YK (2011) Amyloid {beta} peptide1-42 induces internalization and
degradation of β2 adrenergic receptor in prefrontal cortical neurons. J Biol Chem.
286:31852-63. DOI: 10.1074/jbc.M111.244335 !!!
108. Liu W, Dou F, Feng J, Yan Z (2011) RACK1 is
involved in β-amyloid
impairment of muscarinic regulation of GABAergic transmission. Neurobiol. Aging 32:1818-26. DOI: 10.1016/j.neurobiolaging.2009.10.017 !!!
109. Yuen EY, Zhong P, Yan Z (2010) Homeostatic regulation of
glutamatergic transmission by dopamine D4 receptors. Proc. Natl. Acad.
Sci. USA 107:22308-13.
110. Wang Q, Charych EI, Pulito VL, Lee J, Graziane NM, Crozier RA, Revilla-Sanchez R, Kelly M, Dunlop
AJ, Murdoch H, Taylor N, Xie Y, Pausch M, Hayashi-Takagi A, Bates B, Kariya K,
Sawa A, Weinberg RJ, Moss SJ, Houslay MD, Yan Z, Brandon NJ (2011) The psychiatric disease risk factors DISC1
and TNIK interact to regulate synapse composition and function. Mol. Psychiatry 16:1006-23.
DOI: 10.1038/mp.2010.87 ***
111. Liu W, Yuen
EY, Yan
Z (2010) The stress hormone corticosterone increases synaptic AMPA
receptors via SGK regulation of the GDI-Rab4 complex. J. Biol. Chem.
285:6101-8. DOI: 10.1074/jbc.M109.050229 ***
112. Wei J, Liu W, Yan Z (2010) Regulation of AMPA receptor trafficking and function by glycogen
synthase kinase 3. J. Biol. Chem. 285:26369-76.
113. Yuen EY, Liu W, Kafri T, van Praag H, Yan Z
(2010) Regulation of AMPA receptor channels and synaptic plasticity by cofilin
phosphatase Slingshot in cortical neurons. J. Physiol. 588:2361-71. DOI: 10.1113/jphysiol.2009.186353 ###
114. Twelvetrees AE, Yuen EY, Arancibia-Carcamo IL, Rostaing
P, Lumb MJ, Humbert S, Triller A, Saudou F, Yan Z,
Kittler JT (2010) Delivery of GABAARs to synapses is mediated by HAP1-KIF5 and
disrupted by mutant huntingtin. Neuron 65:53-65.
115. Hayashi-Takagi A, Takaki M, Graziane NM, Seshadri
S, Murdoch H, Dunlop AJ, Makino Y, Seshadri AJ, Ishizuka K, Srivastava DP, Xie
Z, Baraban JM, Houslay MD, Tomoda
T, Brandon NJ, Kamiya A, Yan Z, Penzes P, Sawa A (2010)
Disrupted-in-Schizophrenia-1 (DISC1) regulates spines of the glutamate synapse
via Rac1. Nat. Neurosci. 13:327-32.
116. Joiner MA, Lise MF, Yuen EY, Kam A, Hall DD, Malik ZA, Qian H, Chen Y,
Ulrich JD, Burette AC,
Weinberg RJ, Law PY, El-Husseini A, Yan Z, Hell JW (2010) Assembly of a β2-adrenergic receptor- GluR1 signaling
complex for localized cAMP signaling. EMBO J 29:482-95. DOI: 10.1038/emboj.2009.344 ###
117. Yuen EY, Liu W, Karatsoreos IN, Feng J, McEwen
BS, Yan Z (2009) Acute stress enhances glutamatergic transmission in
prefrontal cortex and facilitates working memory. Proc. Natl. Acad. Sci.
USA 106:14075-9.
118. Mandal M and Yan Z (2009) Phosphatidylinositol (4,5)-bisphosphate regulation of
N-methyl-D-aspartate receptor channels in cortical neurons. Mol. Pharm. 76:1349-59. DOI: 10.1124/mol.109.058701 ###
119. Arancibia-Carcamo IL, Yuen EY, Muir J, Lumb MJ, Michels G, Smart TG, Yan
Z, Kittler JT, Moss SJ (2009) Ubiquitin-dependent targeting of GABAARs for
lysosomal degradation regulates the efficacy of neuronal inhibition. Proc.
Natl. Acad. Sci. USA 106:17552-7. DOI: 10.1073/pnas.0905502106 ###
120.
Saliba RS, Gu Z, Yan
Z, Moss SJ (2009) Blocking L-type voltage gated Ca2+ channels with
dihydropyridines reduces gamma-aminobutyric acid type A receptor expression and
synaptic inhibition. J Biol Chem. 284:32544-50. DOI: 10.1074/jbc.M109.040071 ###
121.
Huang YH, Lin Y, Mu
P, Marie H, Liu W, Yan Z, Sorg BA, Schluter O, Zukin SR, Dong Y (2009) In vivo cocaine experience generates
silent synapses. Neuron. 63:40-7. DOI: 10.1016/j.neuron.2009.06.007 ***
122.
Yuen EY, Yan Z
(2009) Dopamine D4 receptors regulate AMPAR trafficking and glutamatergic
transmission in GABAergic interneurons of prefrontal cortex. J. Neurosci. 29:550-62. DOI: 10.1523/JNEUROSCI.5050-08.2009 ###
125.
Smith KR, McAinsh K, Chen G, Arancibia-Carcamo IL, Haucke V, Yan Z, Moss SJ, Kittler JT (2008)
Regulation of inhibitory synaptic transmission by a conserved atypical AP2
interaction within GABAA receptor β and γ- subunits. Neuropharmacology 55:844-50. DOI: 10.1016/j.neuropharm.2008.06.072 ###
126.
Yuen EY, Jiang Q,
Chen P, Feng J, Yan Z (2008) Activation of 5-HT2A/C receptors counteracts
5-HT1A regulation of NMDAR channels in pyramidal neurons of prefrontal cortex. J.
Biol. Chem. 283:17194-204. DOI: 10.1074/jbc.M801713200 ###
127.
Zhong P, Liu W, Gu Z,
Yan Z (2008) Serotonin facilitates LTD induction in prefrontal cortex
via p38 MAPK/Rab5-mediated enhancement of AMPA receptor internalization. J.
Physiol. 586:4465-79. DOI: 10.1113/jphysiol.2008.155143 ###
128.
Yuen EY, Ren Y, Yan
Z (2008) PSD-95 and calcineurin control the sensitivity of NMDA receptors
to calpain cleavage in cortical neurons. Mol. Pharmacol.
74:360-370. DOI: 10.1124/mol.108.046813 ###
129.
Zhong P, Yuen EY, Yan
Z (2008) Modulation of neuronal excitability by serotonin-NMDA interactions
in prefrontal cortex. Mol. and Cell. Neurosci.
38:290-9. DOI: 10.1016/j.mcn.2008.03.003 ###
130.
Kittler JT, Chen G, Kukhtina V, Vahedi-Faridi A, Gu Z, Tretter V, Smith K, McAinsh K, Arancibia-Carcamo L, Saenger W,
Haucke V, Yan Z,
Moss SJ (2008) Regulation of inhibitory synaptic transmission by
GABAA receptor γ2 subunit specific phospho-dependent binding of a YECL motif to the clathrin adaptor AP2. Proc. Natl. Acad. Sci. USA 105:3616-21.
DOI: 10.1073/pnas.0707920105 ###
131.
Chen G, Chen P, Tan
H, Ma D, Dou F, Feng J, Yan Z (2008) Regulation of the NMDA receptor-mediated
synaptic response by acetylcholinesterase inhibitors and its impairment in an
animal model of Alzheimer's disease. Neurobiol.
Aging 29:1795-804. DOI: 10.1016/j.neurobiolaging.2007.04.023!!!
132. Chen P, Gu Z, Liu W, Yan Z (2007) Glycogen synthase kinase 3
regulates NMDA receptor channel trafficking and function
in cortical neurons. Mol. Pharm. 72:40-51. DOI: 10.1124/mol.107.034942 ###
133. Benavides DR, Quinn JJ, Zhong P, Hawasli AH, Kansy JW, DiLeone R, Yan Z, Taylor JR, Bibb JA
(2007) Cyclin-dependent protein kinase 5 controls cocaine responses, motivation
for reward, and striatal neuron excitability. J. Neurosci.
27:12967-76. DOI: 10.1523/JNEUROSCI.4061-07.2007 ***
134. Yuen EY, Liu W, Yan Z (2007) The phosphorylation state of GluR1
subunits determines the susceptibility of AMPA receptors to calpain cleavage. J.
Biol. Chem. 282:16434-40. DOI: 10.1074/jbc.M701283200 ###
135. Yuen EY, Gu Z, Yan Z (2007) Calpain regulation of AMPA receptor
channels in cortical pyramidal neurons. J. Physiol. 580:241-54. DOI: 10.1113/jphysiol.2006.122754 ###
136. Gu Z, Jiang Q, Yan Z (2007) RGS4 modulates serotonin signaling in
prefrontal cortex and links to serotonin dysfunction
in a rat model of schizophrenia. Mol. Pharmacol.
71:1030-9. DOI: 10.1124/mol.106.032490 ***
137. Kastning K, Kukhtina V, Kittler JT, Chen G, Pechstein A, Enders S, Lee SH, Sheng M, Yan Z,
Haucke V (2007) Molecular determinants for the interaction between AMPA
receptors and the clathrin adaptor complex AP-2. Proc.
Natl. Acad. Sci. USA 104:2991-6. DOI: 10.1073/pnas.0611170104 ###
138. Liu W, Yuen EY, Allen PB, Feng J, Greengard P, Yan Z (2006)
Adrenergic modulation of NMDA receptors in prefrontal cortex is differentially
regulated by RGS proteins and spinophilin. Proc.
Natl. Acad. Sci. USA 103:18338-43. DOI: 10.1073/pnas.0604560103 ###
139. Allen PB, Zachariou V, Svenningsson P, Lepore AC, Centonze D, Costa C,
Rossi S, Bender G, Chen G, Feng J, Snyder GL, Bernardi G, Nestler EJ, Yan Z,
Calabresi P, Greengard P (2006) Distinct roles for spinophilin
and neurabin in dopamine-mediated plasticity. Neuroscience
140:897-911. DOI: 10.1016/j.neuroscience.2006.02.067 ###
140. Jiang Q, Yan Z, Feng J (2006) Neurotrophic factors protect against
rotenone toxicity on dopaminergic neurons through a microtubule-dependent
mechanism. J. Biol. Chem. 281:29231-400. DOI: 10.1074/jbc.M602740200 !!!
141.
Jiang Q, Yan Z,
Feng J (2006) Activation of group III metabotropic glutamate receptors
attenuates rotenone toxicity on dopaminergic neurons through a
microtubule-dependent mechanism. J. Neurosci.
26:4318-28. DOI: 10.1523/JNEUROSCI.0118-06.2006 ###
142.
Chen G, Kittler JT,
Moss SJ, Yan Z (2006) Dopamine D3 receptors regulate GABA(A) receptor
function through a phospho-dependent endocytosis mechanism in nucleus accumbens. J. Neurosci.
26:2511-9. DOI:
10.1523/JNEUROSCI.4712-05.2006 ###
143. Gu Z, Jiang Q, Yuen EY, Yan Z (2006) Activation of dopamine D4 receptors
induces synaptic translocation of CaMKII in cultured prefrontal cortical
neurons. Mol. Pharmacol.
69:813-22. DOI: 10.1124/mol.105.018853 ###
144. Wang X, Gu Z, Zhong P, Chen G, Feng J, Yan Z (2006) Aberrant
regulation of NMDAR functions by dopamine D4 receptors in rats after
phencyclidine exposure. Mol. and Cell. Neurosci.
31:15-25. DOI: 10.1016/j.mcn.2005.08.018 ***
145. Yuen EY, Jiang Q, Chen P, Gu Z, Feng J, Yan Z (2005) Serotonin 5-HT1A
receptors regulate NMDA receptor channels through a microtubule-dependent
mechanism. J. Neurosci. 25: 5488-501. DOI: 10.1523/JNEUROSCI.1187-05.2005 ###
146. Kittler JT, Chen G, Honing S, Bogdanov Y, McAinsh
K, Arancibia-Carcamo IL, Jovanovic JN, Pangalos MN, Haucke V, Yan Z and
Moss SJ (2005) Phospho-dependent binding of the clathrin
AP2 adaptor complex to GABA(A) receptors regulates the efficacy of inhibitory
synaptic transmission. Proc. Natl. Acad. Sci. USA 102:14871-6. DOI: 10.1073/pnas.0506653102 ###
147. Gu Z, Jiang Q, Fu AKY, Ip NY, Yan Z (2005) Regulation of NMDA
receptors by neuregulin signaling in prefrontal cortex. J. Neurosci. 25: 4974-84. DOI: 10.1523/JNEUROSCI.1086-05.2005 ***
148. Yuen EY, Jiang Q, Feng J, Yan Z (2005) Microtubule regulation of NMDA
receptor channels in neurons. J. Biol. Chem. 280:29420-7. DOI: 10.1074/jbc.M504499200 ###
149.
Wu HY, Yuen EY, Lu
YF, Matsushita M, Matsui H, Yan Z, Tomizawa K (2005) Regulation
of NMDA receptors by calpain in cortical neurons. J. Biol. Chem.
280: 21588-93. DOI: 10.1074/jbc.M501603200
150.
Tyszkiewicz JP, Yan
Z (2005) β-Amyloid peptides impair PKC-dependent
functions of metabotropic glutamate receptors in prefrontal cortical neurons.
J. Neurophysiol. 93: 3102-11. DOI: 10.1152/jn.00939.2004 !!!
151. Gu Z and Yan Z (2004) Bi-directional
regulation of CaMKII activity by dopamine D4 receptors in prefrontal cortex. Mol. Pharmacol. 66: 948-55. DOI: 10.1124/mol.104.001404 ###
152. Zhong P and Yan Z (2004)
Chronic antidepressant treatment alters the serotonergic regulation of GABA
transmission in prefrontal cortical pyramidal neurons. Neurosci.
129: 65-73. DOI: 10.1016/j.neuroscience.2004.06.072 ***
153. Tan H, Zhong P, Yan Z (2004)
Corticotropin-releasing factor and acute stress prolongs serotonergic
regulation of GABA transmission in prefrontal cortical pyramidal neurons. J. Neurosci. 24: 5000-8. DOI: 10.1523/JNEUROSCI.0143-04.2004 ***
154. Yan Z and Feng J
(2004) Alzheimer's disease: interactions between cholinergic functions and β-amyloid. Current Alzheimer
Research (review) 1: 241-8. DOI: 10.2174/1567205043331992 !!!
155. Chen G, Greengard P, Yan Z (2004)
Potentiation of NMDA receptor currents by dopamine D1 receptors in prefrontal
cortex. Proc. Natl. Acad. Sci. USA 101: 2596-600. DOI: 10.1073/pnas.0308618100 ###
156. Tyszkiewicz JP, Gu Z, Wang X, Cai X, Yan
Z (2004) Group II metabotropic glutamate receptors enhance NMDA receptor
currents via a protein kinase C-dependent mechanism in pyramidal neurons of rat
prefrontal cortex. J. Physiology (London) 554: 765-77. DOI: 10.1113/jphysiol.2003.056812 ###
157. Wang X, Zhong P, Gu Z, Yan Z (2003) Regulation of NMDA receptors by
dopamine D4 signaling in prefrontal cortex. J. Neurosci.
23: 9852-61. DOI: 10.1523/JNEUROSCI.23-30-09852.2003 ###
158. Zhong P, Gu Z, Wang X, Jiang H, Feng J, Yan Z (2003) Impaired
modulation of GABAergic transmission by muscarinic receptors in a mouse
transgenic model of Alzheimer's disease. J. Biol. Chem. 278:
26888-96. DOI: 10.1074/jbc.M302789200 !!!
159. Davila V, Yan Z, Craciun LC, Logothetis D, Sulzer D (2003) D3
dopamine autoreceptors do not activate GIRK channel
currents in substantia nigra dopamine neurons. J. Neurosci.
23: 5693-7. DOI: 10.1523/JNEUROSCI.23-13-05693.2003 ###
160. Gu Z, Zhong P, Yan Z (2003) Activation of muscarinic
receptors inhibits β-amyloid peptide - induced signaling in cortical slices. J. Biol.
Chem. 278: 17546-56. DOI: 10.1074/jbc.M209892200 !!!
161. Ma X, Zhong P, Gu Z, Feng J, Yan Z (2003) Muscarinic potentiation of
GABAA receptor currents is gated by insulin signaling in the
prefrontal cortex. J. Neurosci. 23:
1159-68. DOI: 10.1523/JNEUROSCI.23-04-01159.2003 !!!
162. Wang X, Zhong P, Yan Z (2002) Dopamine D4 receptors modulate
GABAergic signaling in pyramidal neurons of prefrontal cortex. J.
Neurosci.22: 9185-93. DOI: 10.1523/JNEUROSCI.22-21-09185.2002 ###
163. Cai X, Gu Z, Zhong P, Ren Y, Yan Z (2002) Serotonin 5-HT(1A)
receptors regulate AMPA receptor channels through inhibiting CaMKII in
prefrontal cortical pyramidal neurons. J. Biol. Chem. 277:
36553-62. DOI: 10.1074/jbc.M203752200 ###
164. Yan Z (2002)
Regulation of GABAergic inhibition by serotonin signaling in prefrontal cortex:
molecular mechanisms and functional implications. Molecular Neurobiology
(review) 26: 203-16. DOI: 10.1385/MN:26:2-3:203 ###
165. Cai X, Flores-Hernandez J, Feng J, Yan Z (2002) Activity-dependent
bi-directional regulation of GABAA receptor channels by serotonin
5-HT4 receptors in pyramidal neurons of the prefrontal cortex. J.
Physiology (London) 540: 743-59. DOI: 10.1113/jphysiol.2001.013391 ###
166. Yan Z, Chi P, Bibb
JA, Ryan TA, Greengard P (2002) Roscovitine: a novel
regulator of P/Q-type calcium channels and transmitter release in central
neurons. J. Physiology (London) 540: 761-70. DOI: 10.1113/jphysiol.2001.013376 ###
167. Feng J, Cai X, Zhao J, Yan Z (2001) 5-HT2 receptors modulate GABAA
receptor channels through activation of anchored protein kinase C in prefrontal
cortical neurons. J. Neurosci. 21:
6502-11. DOI: 10.1523/JNEUROSCI.21-17-06502.2001 ###
168. Liu F, Ma X, Ule J, Nishi A, Bibb JA, DeMaggio AJ, Yan Z, Nairn AC,
Greengard P (2001) Regulation of cyclin dependent kinase 5 and casein kinase I
by metabotropic glutamate receptors. Proc. Natl. Acad. Sci. USA
98: 11062-8.
169. Yan Z,
Flores-Hernandez J, Surmeier DJ (2001) Coordinated expression of muscarinic
receptor mRNAs in striatal medium spiny neurons. Neuroscience
103: 1017-24. DOI: 10.1016/s0306-4522(01)00039-2 ###
170. Bibb JA, Chen J, Taylor JR, Svenningsson P, Nishi A, Snyder GL, Yan Z,
Sagawa ZK, Ouimet CC, Nairn AC, Nestler EJ, Greengard P (2001) Effects of
chronic exposure to cocaine are regulated by the neuronal protein Cdk5. Nature
410: 376-80. DOI: 10.1038/35066591 ***
171.
Bibb JA, Yan Z,
Svenningsson P, Snyder GL, Pieribone VA, Nairn AC,
Messer A, Greengard P (2000) Severe deficiencies in dopamine signaling in
presymptomatic Huntington's disease mice. Proc. Natl. Acad. Sci. USA
97: 6809-14. DOI: 10.1073/pnas.120166397 !!!
172.
Feng J, Yan Z,
Ferreira AB, Tomizawa K, Liauw JA, Zhuo M, Allen PB,
Ouimet CC, Greengard P (2000) Regulation of the formation and function of
dendritic spines by spinophilin. Proc. Natl.
Acad. Sci. USA 97: 9287-92.
173. Flores-Hernandez J, Hernandez S, Snyder GL, Yan Z, Fienberg AA, Moss
SJ, Greengard P, Surmeier DJ (2000) D1 dopamine receptor activation reduces
GABAA receptor currents in neostriatal neurons
through a PKA/DARPP-32 /PP-1 signaling cascade. J. Neurophysiology
83: 2996-3004. DOI: 10.1152/jn.2000.83.5.2996 ###
174.
Yan Z, Hsieh-Wilson L, Feng J, Tomizawa K, Allen PB, Fienberg AA, Nairn AC,
Greengard P (1999) Protein phosphatase 1 modulation of neostriatal
AMPA channels: regulation by DARPP-32 and spinophilin.
Nature Neuroscience 2: 13-17. DOI: 10.1038/4516 ###
175.
Yan Z, Feng J, Fienberg AA, Greengard P (1999) D2 dopamine receptors induce MAPK
and CREB phosphorylation in neurons. Proc. Natl. Acad. Sci. USA
96: 11607-12.
176. Bibb JA, Snyder GL, Nishi A, Yan Z, Meijer L, Fienberg AA et al. (1999)
Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling
in neurons. Nature 402: 669-71.
177. Stwart A, Yan Z, Surmeier DJ, Foehring R
(1999) Muscarine modulates Ca2+ currents in rat sensorymotor
pyramidal cells via two distinct pathways. J. Neurophysiol.
81: 72-84. DOI: 10.1152/jn.1999.81.1.72 ###
178. Mermelstein PG, Song WJ, Tkatch T, Yan Z, Surmeier DJ (1998)
Inwardly rectifying potassium (IRK) currents are correlated with IRK subunit
expression in rat nucleus accumbens medium spiny
neurons. J. Neurosci. 18:
6650-61. DOI: 10.1523/JNEUROSCI.18-17-06650.1998 ###
179. Chen Q, Veenman L, Knopp K, Yan Z, Medina
L, Song WJ, Surmeier DJ, Reiner A (1998) Evidence for the preferential
localization of GluR1 subunits of AMPA receptors to the dendritic spines of
medium spiny neurons in rat striatum. Neuroscience
83: 749-61. DOI: 10.1016/s0306-4522(97)00452-1 ###
180. Yan Z and Surmeier
DJ (1997) D5 dopamine receptors enhance Zn2+-sensitive GABAA currents in
striatal cholinergic interneurons through a protein kinase A/protein
phosphatase 1 cascade. Neuron 19: 1115-26. [PDF file] DOI: 10.1016/s0896-6273(00)80402-x ###
181. Yan Z, Song WJ,
Surmeier DJ (1997) D2 dopamine receptors reduce N-type Ca2+ currents in rat neostriatal cholinergic interneurons through a
membrane-delimited, protein kinase C-insensitive pathway. J. Neurophysiol. 77: 1003-15.
182. Surmeier DJ, Song WJ, Yan Z (1996) Coordinated expression of
dopamine receptors in neostriatal medium spiny
neurons. J. Neurosci. 16: 6579-91. DOI: 10.1523/JNEUROSCI.16-20-06579.1996 ###
183. Yan Z and Surmeier
DJ (1996) Muscarinic (m2/m4) receptors reduce N- and P-type Ca2+ currents in
rat neostriatal cholinergic interneurons through a
fast, membrane-delimited, G-protein pathway. J. Neurosci.
16: 2592-604.
***:
Papers related to mental disorders;
!!!:
Papers related to neurodegenerative diseases;
###:
Papers related to basic neurobiological mechanisms;
^^^:
Papers related to stem cells.