CPT Personnel

Center for Protein Therapeutics

Projects - FY2009

1. Physiologically-based pharmacokinetic (PBPK) modeling of IgG (Balthasar)

2. Investigation of the impact of FcRn affinity on subcutaneous bioavailability of mAb (Balthasar)

3. Investigation of the pharmacokinetics of immune complexes in mice (Balthasar)

4. Lymphatic uptake of proteins: Use of microPET in rodent studies (Morris)

5. Multi-scale systems analysis of anti-CD20 mab pharmacodynamics (Mager)

6. Accurate and reliable quantification of monoclonal antibodies (mAB) in tissues (Qu)

7. Quantitative characterization of in vivo immune complexes of mAB (Qu)

8. Lymphatic uptake of proteins: Use of whole body fluorescence in rodent studies (Morris)

9. Bioavailability of Mabs following sc administration (Mager / Balu-Iyer)