Center for Protein Therapeutics


Home Page  Sponsors Core Members Management Committee Executive Committee  SoPPS News

CPT Personnel







News from the Center for Protein Therapeutics

Note: Number refers to the running list of CPT projects

64. Physiologically-based pharmacokinetic (PBPK) modeling of IgG (Balthasar)

65. Determinants of mAb brain distribution in mouse models of Alzheimer’s Disease: Investigation of FcRn binding and charge (Balthasar)

66. Evaluation of mAb Brain Disposition in Alzheimer’s Disease (Morris)

67. Investigation of the effects of co-administered drugs on mAb pharmacokinetics (Balthasar)

68. Inclusion of “Tissue Target Dynamics” in Minimal PBPK Models for mAb PK/PD Assessment (Jusko)

69. Quantitative Structure-Absorption Relationships (QSAR) of mAbs (Mager)

70. Understanding and Characterizing the Bystander Effect for Antibody-Drug Conjugates (Shah)

71. Suppression of Free TNF-α with Infliximab in Plasma and Joints in CIA Rats (Jusko)

72. Development of Translational Physiologically-Based Pharmacokinetic (PBPK) Model for Antibody-Drug  Conjugates (ADCs) (Shah)

73. Evaluation of the role of renal clearance and metabolism in the altered pharmacokinetics of IgG in diabetes mellitus (Morris)

74. Very-high-resolution LC/MS for rapid, selective, sensitive and extensive characterization and quantification of antibody-drug conjugate to support PK studies (Qu) – partial support

75. Elimination Mechanism for Antibody-Drug Conjugates (ADCs) with Higher DAR (Shah) – partial support



Center for Protein Therapeutics, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, The State University of New York