375-300 BC

Diocles was a Greek physician who subscribed to the cardiocentric theory of the body, wherein the heart was the source of sensation and intelligence.

Diocles wrote on apoplexy, what he termed the severe form of a stroke. He saw it as originating in the region around the aorta. Paralysis, on the other hand, the less severe form of apoplexy, began in the regions of the thinner ramifications of the aorta. The notions about apoplexy were drawn from an idea that the disease came from an obstruction in and around blood vessels that came from cold and thick phlegm blocking the flow of pneuma.