Chang-Xing Ma
mcxsAssociate Professor

Department of Biostatistics
University at Buffalo
Kimball rm716
Buffalo, NY 14214

PHONE: (716) 829-2758
FAX: (716) 829-2200

BA, Master, PhD, NANKAI, 1997

Research Interests:

Statistical Genetics, Experimental Design, Uniform Design, Orthogonal Design, Public Health

Text Books

1.       R. Wu, C.X. Ma, G Casella. Statistical Genomics of Complex Traits: Linkage, Disequilibrium and QTL. Springer New York, 2007

2.       K.T. Fang and C.X. Ma, Uniform and Orthogonal Designs (in Chinese), Science Press, September 2001, Beijing.

Selected Publications

Tian, L, Ma CX, Vexler, A. (2009). A Parametric Bootstrap Test for Comparing Heteroscedastic Regression Models, Communications in Statistics - Simulation and Computation. Accepted.

Ma CX, Qibin Yu, Arthur Berg, Derek Drost, Evandro Novaes, Guifang Fu, John Stephen Yap, Aixin Tan, Matias Kirst, Yuehua Cui and Rongling Wu (2008) A Statistical Model for Testing the Pleiotropic Control of Phenotypic Plasticity for a Count Trait, Genetics, 179: 627-536.

Ma CX, Li Y and Wu RL (2008), Modeling the Genetic Control of HIV-1 Dynamics after Highly Active Antiretroviral Therapy, Current Genomics, 9 (3): 208-211.

Samina Raja, Ma CX, & Pavan Yadav (2008). Beyond Food Deserts, Measuring and Mapping Racial Disparities in, Neighborhood Food Environments. Journal of Planning Education and Research, 27 (4): 469-482.

Lo KC, Ma CX, Bundy BN, Pomeroy SL, Eberhart CG, Cowell JK (2007). Gain of 1q is a potential univariate negative prognostic marker for survival in medulloblastoma. Clin Cancer Res. 13(23):7022-8.

Wu, R.L., W. Hou, Y.H. Cui, H.Y. Li, T. Liu, S. Wu, C-X. Ma, and Y. Zeng. (2007) Modeling the genetic architecture of complex traits with molecular markers. Recent Patent on Nanotechnology, 1, 41-49.

Alonso E. Concha Leon, Kelly Michienzi, Chang-Xing Ma, Alastair A. Hutchison (2007) Serum Caffeine Concentrations in Preterm Neonates, Amer J Perinatol. 24(1):39-47.

Steven B. Morse, Samuel S. Wu, Changxing Ma, Mario Ariet, Michael Resnick, and Jeffrey Roth (2006) Racial and Gender Differences in the Viability of Extremely Low Birth Weight Infants: A Population-Based Study. Pediatrics, 117 (1): E106-E112.

Tang Y, Ma CX, Cui W, Chang V, Ariet M, Morse SB, Resnick MB, Roth J. (2006) The Risk of Birth Defects in Multiple Births: A Population-Based Study. Matern Child Health J. 21;:1-7

Cui W, Ma CX, Tang Y, Chang V, Rao PV, Ariet M, Resnick MB, Roth J.(2005) Sex differences in birth defects: A study of opposite-sex twins. Birth Defects Res A Clin Mol Teratol. 73(11):876-80.

Lin M, Ma CX, Zhao W, Cheverud JM, Wu R.(2005) Mechanistic mapping of ontogenetic growth based on biological principles. Growth Dev Aging. 69(1):31-7.

Wu R, Ma CX, Hou W, Corva P, Medrano JF. (2005) Functional mapping of quantitative trait loci that interact with the hg mutation to regulate growth trajectories in mice. Genetics. 171(1):239-49.

Wu, R., Ma, C.X. (2005) A general framework for statistical linkage analysis in multivalent tetraploids. Genetics. 170(2):899-907.

Wu RL, Ma CX, Lin M, Casella G (2004). A general framework for analyzing the genetic architecture of developmental characteristics, GENETICS 166 (3): 1541-1551.

Tekwe CD, Carter RL, Ma CX, Algina J, Lucas ME, Roth J, Ariet M, Fisher T, Resnick MB (2004). An empirical comparison of statistical models for value-added assessment of school performance, JOURNAL OF EDUCATIONAL AND BEHAVIORAL STATISTICS 29 (1): 11-35.


Wu, R.; Ma, C. X.; Wu, J.; Fang, W.; Casella, G.L

Population genetics of heterosis: effects of Hardy-Weinberg disequilibrium. Silvae Genetica - Volume 53 p. 1-6 (2004). [Full Text]

Zhao W, Ma CX, Cheverud JM and Wu RL

A unifying statistical model for QTL mapping of genotype-sex interaction for developmental trajectories.
Physiological Genomics 19: 218-227, 2004. [Full Text]

Wu RL, Ma CX, and Casella G

A Mixed Polyploid Model for Linkage Analysis in Outcrossing Tetraploids Using a Pseudo-Test Backcross Design.
Journal Of Computational Biology 11 (4): 563-580, 2004.[Full Text]

Wu RL, Ma CX, Lin M, Wang ZH, and Casella G

Functional mapping of quantitative trait loci underlying growth trajectories using a transform-both-sides logistic model.
Biometrics 60 (3): 729-738, 2004.[Full Text]

Ma CX, Wu RL and Casella G

FunMap: functional mapping of complex traits.
Bioinformatics 20(11):1808-11 Jul 2004. [Full Text]

Zhao W, Wu RL, Ma CX and Casella G

A fast algorithm for functional mapping of complex traits
Genetics, Vol 167 (4), 2133-2137 August 2004. [Full Text]

Wu RL, Ma CX, Lin M, and Casella G

A General Framework for Analyzing the Genetic Architecture of Developmental Characteristics
Genetics, Vol. 166 (3), 1541-1551 March 2004. [Full Text]

Wu RL, Ma CX and Casella G

A bivalent polyploid model for mapping quantitative trait loci in outcrossing tetraploids
Genetics, Vol. 166 (1), 581-595 January 2004. [Full Text]

Ma CX, Fang KT

A new approach to construction of nearly uniform designs
Int. J. Materials and Product Technology, Vol. 20, 115-126, 2004 [Abstract]

Wu RL, Ma CX, Lou XY, Casella G

Molecular dissection of allometry, ontogeny, and plasticity: A genomic view of developmental biology
BIOSCIENCE 53 (11): 1041-1047 NOV 2003 [Full Text]

Ma CX, Lin M, Littell RC, Yin T and Wu RL

A likelihood approach for mapping growth trajectories using dominant markers in a phase-unknown full-sib family
Theor Appl Genet. 2004 [Full Text]

Wu RL, Ma CX, Zhao W, and Casella G

Functional mapping for quantitative trait loci governing growth rates: a parametric model
Physiol Genomics 14: 241249, 2003

Ma CX, Casella G, Littell RC, Khuri AI, and Wu RL

Exponential mapping of quantitative trait loci governing allometric relationships in organisms
Journal of Mathematical Biology 47 (4) 313 - 324 (2003)

Wu RL, Ma CX, Yang, CK, Chang M, Littell RC, SANTRA U, Wu SS, Yin TM, Huang MR, Wang MX, and Casella G

Quantitative trait loci for growth trajectories in Populus
GENETICAL RESEARCH 81 (3): 51-64 JUN 2003

Chan, LY, Ma CX, and Goh TN

Orthogonal Arrays for Experiments with Lean Designs
Journal of Quality Technology 35 (2) 123-138 April 2003

Ma CX, Fang KT ,and Lin DKJ

A note on uniformity and orthogonality, Available online 2 October 2001
Journal of Statistical Planning and Inference 113 (1) 323-334 2003

Ma CX, Casella G, Shen ZJ, Osborn TC, and Wu RL

A Unified Framework for Mapping Quantitative Trait Loci in Bivalent Tetraploids Using Single-dose Restriction Fragments: A Case Study from Alfalfa
Genome Research 12 (12), 1974-1981, December 2002

Wu RL, Ma CX, Gallo-Meagher M, Littell RC, and Casella G

Statistical Methods for Dissecting Triploid Endosperm Traits Using Molecular Markers: An Autogamous Model
Genetics 162 (2): 875-892 Oct 2002

Wu RL, Ma CX ,Littel RC, and Casella G

A Statistical Model for the Genetic Origin of Allometric Scaling Laws in Biology
Journal of Theoretical Biology 219 (1): 121-135 2002

Ma CX, Casella G, and Wu RL

Functional mapping of quantitative trait loci underlying the character process: A theoretical framework
Genetics 161 (4): 1751-1762 Aug 2002

Wu RL, Lou XY, Ma CX, Wang X, Larkins BA, and Casella G

An improved genetic model generates high-resolution mapping of QTL for protein quality in maize endosperm
PNAS 99 (17): 1128111286 2002

Wu RL, Ma CX ,and Casella G

A Bivalent Polyploid Model for Linkage Analysis in Outcrossing Tetraploids
Theoretical Population Biology 62 (2): 129-151 2002 ( from IdealLibrary)

Wu RL, Ma CX, Chang M, Littell RC, Wu SS, Yin TM, Huang MR, Wang MX, and Casella G

A logistic mixture model for characterizing genetic determinants causing differentiation in growth trajectories
GENETICAL RESEARCH 79 (3): 235-245 JUN 2002

Wu SS, Ma CX, Wu RL and Casella G

A hierarchical statistical model for estimating population properties of quantitative genes

BMC Genetics 3 (10): 2002 (This article is available from


Wu RL, Ma CX, Painter I, Zeng ZB

Simultaneous Maximum Likelihood Estimation of Linkage and Linkage Phases in Outcrossing Species
Theoretical Population Biology 61 (3): 349-363 2002

Wu RL, Ma CX, Wu SS, Zeng ZB

Linkage mapping of sex-specific differences
GENETICAL RESEARCH 79 (1): 85-96 FEB 2002

Wu RL, Ma CX, Casella G

Joint linkage and linkage disequilibrium mapping of quantitative trait loci in natural populations
GENETICS 160 (2): 779-792 FEB 2002

Wu RL, Ma CX, Zhu J, Casella G

Mapping epigenetic quantitative trait loci (QTL) altering a developmental trajectory
GENOME 45 (1): 28-33 FEB 2002

Fang KT, Ma CX

Wrap-around L-2-discrepancy of random sampling, Latin hypercube and uniform designs
J COMPLEXITY 17 (4): 608-624 DEC 2001

Wu SS, Wu RL, Ma CX, Zeng ZB, Yang, MCK, Casella G

A multivalent pairing model of linkage analysis in autotetraploids
GENETICS 159 (3): 1339-1350 NOV 2001

Fang KT, Ma CX, Winker P

Centered L-2-discrepancy of random sampling and Latin hypercube design, and construction of uniform designs
MATH COMPUT 71 (237): 275-296 2002

Ma CX, Fang KT, Lin DKJ

On the isomorphism of fractional factorial designs
J COMPLEXITY 17 (1): 86-97 MAR 2001

Ma CX, Fang KT

A note on generalized aberration in factorial designs
METRIKA 53 (1): 85-93 2001

Ma CX, Fang KT, Liski E

A new approach in constructing orthogonal and nearly orthogonal arrays
METRIKA 50 (3): 255-268 2000

Fang KT, Lin DKJ, Ma CX

On the construction of multi-level supersaturated designs
J STAT PLAN INFER 86 (1): 239-252 APR 15 2000


Research Projects


  Child Abuse and Neglect

  Analysis of Predictors of Healthy Outcomes for Medicaid Eligible Women, Their Infants and Young Children

  Experimental Design

  Statistical Genetics



Web-based functional mapping software

Polyploid Mapping (Windows 95 or 2000)


Polyploid Mapping (Windows XP)


Sample Size Calculator for Barnard designs in clinical trial, two samples, two stages

Useful Link

uniform designs

orthogonal designs