Chang-Xing
Ma
Associate Professor
Department of Biostatistics
Kimball rm716
FAX: (716) 829-2200
E-MAIL: cxma@buffalo.edu
BA, Master, PhD, NANKAI, 1997
Research Interests:
Statistical Genetics, Experimental Design, Uniform Design, Orthogonal Design, Public Health
Text Books
1.
R.
Wu, C.X. Ma, G Casella. Statistical
Genomics of Complex Traits: Linkage, Disequilibrium and QTL. Springer
2.
K.T.
Fang and C.X. Ma, Uniform and
Orthogonal Designs (in Chinese), Science Press, September 2001,
Selected
Publications
Tian,
L, Ma CX, Vexler, A. (2009). A Parametric Bootstrap Test for Comparing
Heteroscedastic Regression Models, Communications
in Statistics - Simulation and Computation. Accepted.
Ma CX, Qibin Yu, Arthur Berg, Derek Drost,
Evandro Novaes, Guifang Fu, John Stephen Yap, Aixin Tan, Matias Kirst, Yuehua
Cui and Rongling Wu (2008) A Statistical
Model for Testing the Pleiotropic Control of Phenotypic Plasticity for a Count
Trait, Genetics, 179: 627-536.
Ma CX, Li Y and Wu RL (2008), Modeling the
Genetic Control of HIV-1 Dynamics after Highly Active Antiretroviral Therapy, Current Genomics, 9 (3): 208-211.
Samina
Raja, Ma CX, & Pavan Yadav
(2008). Beyond Food Deserts, Measuring
and Mapping Racial Disparities in, Neighborhood Food Environments. Journal of Planning Education and Research,
27 (4): 469-482.
Lo KC, Ma CX, Bundy BN, Pomeroy SL, Eberhart
CG, Cowell JK (2007). Gain of 1q is a potential univariate negative prognostic
marker for survival in medulloblastoma. Clin Cancer Res. 13(23):7022-8.
Wu,
R.L., W. Hou, Y.H. Cui, H.Y. Li, T. Liu, S. Wu, C-X. Ma, and Y. Zeng. (2007) Modeling the genetic architecture of
complex traits with molecular markers. Recent
Patent on Nanotechnology, 1,
41-49.
Alonso
E. Concha Leon, Kelly Michienzi, Chang-Xing
Ma, Alastair A. Hutchison (2007) Serum Caffeine Concentrations in Preterm
Neonates, Amer J Perinatol. 24(1):39-47.
Steven
B. Morse, Samuel S. Wu, Changxing Ma,
Mario Ariet, Michael Resnick, and Jeffrey Roth (2006) Racial and Gender
Differences in the Viability of Extremely Low Birth Weight Infants: A
Population-Based Study. Pediatrics,
117 (1): E106-E112.
Tang Y,
Ma CX, Cui W, Chang V, Ariet M,
Morse SB, Resnick MB, Roth J. (2006) The Risk of Birth Defects in Multiple
Births: A Population-Based Study. Matern
Child Health J. 21;:1-7
Cui W, Ma CX, Tang Y, Chang V, Rao PV, Ariet
M, Resnick MB, Roth J.(2005) Sex
differences in birth defects: A study of opposite-sex twins. Birth Defects Res A Clin Mol Teratol. 73(11):876-80.
Lin M, Ma CX, Zhao W, Cheverud JM, Wu R.(2005)
Mechanistic mapping of ontogenetic growth based on biological principles. Growth Dev Aging. 69(1):31-7.
Wu R, Ma
CX, Hou W, Corva P, Medrano JF. (2005) Functional mapping of quantitative trait loci that
interact with the hg mutation to regulate growth trajectories in mice. Genetics. 171(1):239-49.
Wu, R.,
Ma, C.X. (2005) A general framework
for statistical linkage analysis in multivalent tetraploids. Genetics. 170(2):899-907.
Wu RL, Ma CX, Lin M, Casella G (2004). A general framework for analyzing the
genetic architecture of developmental characteristics, GENETICS
166 (3): 1541-1551.
Tekwe
CD, Carter RL, Ma CX, Algina J, Lucas ME, Roth J, Ariet M, Fisher T,
Resnick MB (2004). An empirical comparison of statistical models for
value-added assessment of school performance, JOURNAL OF EDUCATIONAL
AND BEHAVIORAL STATISTICS 29 (1): 11-35.
Wu, R.; Ma, C. X.; Wu, J.; Fang, W.; Casella, G.L
Population genetics of heterosis: effects of Hardy-Weinberg disequilibrium. Silvae Genetica - Volume 53 p. 1-6 (2004). [Full Text]
Zhao W, Ma CX, Cheverud JM and Wu RL
A unifying statistical model for QTL mapping of genotype-sex
interaction for developmental trajectories.
Physiological Genomics 19: 218-227, 2004. [Full Text]
Wu RL, Ma CX, and Casella G
A Mixed Polyploid Model for Linkage Analysis in Outcrossing
Tetraploids Using a Pseudo-Test Backcross Design.
Journal Of Computational Biology 11 (4): 563-580, 2004.[Full
Text]
Wu RL, Ma CX, Lin M, Wang ZH, and Casella G
Functional mapping of quantitative trait loci underlying
growth trajectories using a transform-both-sides logistic model.
Biometrics 60 (3): 729-738, 2004.[Full
Text]
Ma CX, Wu RL and Casella G
FunMap: functional mapping of complex traits.
Bioinformatics 20(11):1808-11 Jul 2004. [Full Text]
Zhao W, Wu RL, Ma CX and Casella G
A fast algorithm for functional mapping of complex traits
Genetics, Vol 167 (4), 2133-2137 August 2004. [Full Text]
Wu RL, Ma CX, Lin M, and Casella G
A General Framework for Analyzing the Genetic Architecture of
Developmental Characteristics
Genetics, Vol. 166 (3), 1541-1551 March 2004. [Full Text]
Wu RL, Ma CX and Casella G
A bivalent polyploid model for mapping quantitative trait
loci in outcrossing tetraploids
Genetics, Vol. 166 (1), 581-595 January 2004. [Full Text]
Ma CX, Fang KT
A new approach to construction of nearly uniform designs
Int. J. Materials and Product Technology, Vol. 20, 115-126, 2004 [Abstract]
Wu RL, Ma CX,
Lou XY, Casella G
Molecular dissection of allometry, ontogeny, and plasticity:
A genomic view of developmental biology
BIOSCIENCE 53 (11): 1041-1047 NOV 2003 [Full Text]
Ma CX, Lin M, Littell RC, Yin T and Wu RL
A likelihood approach for mapping growth trajectories using
dominant markers in a phase-unknown full-sib family
Theor Appl Genet. 2004 [Full
Text]
Wu RL, Ma CX, Zhao W, and Casella G
Functional mapping for quantitative trait loci governing
growth rates: a parametric model
Physiol Genomics 14: 241–249, 2003
Ma CX, Casella G, Littell RC, Khuri AI, and Wu
RL
Exponential mapping of quantitative trait loci governing
allometric relationships in organisms
Journal of Mathematical Biology 47 (4) 313 - 324 (2003)
Wu RL, Ma CX, Yang, CK, Chang M, Littell RC, SANTRA U, Wu SS, Yin TM, Huang MR, Wang MX, and Casella G
Quantitative trait loci for growth trajectories in Populus
GENETICAL RESEARCH 81 (3): 51-64 JUN 2003
Chan, LY, Ma CX, and Goh TN
Orthogonal Arrays for Experiments with Lean Designs
Journal of Quality Technology 35 (2) 123-138 April 2003
Ma CX, Fang KT ,and Lin DKJ
A note on uniformity and orthogonality, Available online 2
October 2001
Journal of Statistical Planning and Inference 113 (1) 323-334 2003
Ma CX, Casella G, Shen ZJ, Osborn TC, and Wu RL
A Unified Framework for Mapping Quantitative Trait Loci in
Bivalent Tetraploids Using Single-dose Restriction Fragments: A Case Study from
Alfalfa
Genome Research 12 (12), 1974-1981, December 2002
Wu RL, Ma CX, Gallo-Meagher M, Littell RC, and Casella G
Statistical Methods for Dissecting Triploid Endosperm Traits
Using Molecular Markers: An Autogamous Model
Genetics 162 (2): 875-892 Oct 2002
Wu RL, Ma CX ,Littel RC, and Casella G
A Statistical Model for the Genetic Origin of Allometric
Scaling Laws in Biology
Journal of Theoretical Biology 219 (1): 121-135 2002
Ma CX, Casella G, and Wu RL
Functional mapping of quantitative trait loci underlying the
character process: A theoretical framework
Genetics 161 (4): 1751-1762 Aug 2002
Wu RL, Lou XY, Ma CX, Wang X, Larkins BA, and Casella G
An improved genetic model generates high-resolution mapping
of QTL for protein quality in maize endosperm
PNAS 99 (17): 11281–11286 2002
Wu RL, Ma CX ,and Casella G
A Bivalent Polyploid Model for Linkage Analysis in
Outcrossing Tetraploids
Theoretical Population Biology 62 (2): 129-151 2002 ( from
IdealLibrary)
Wu RL, Ma CX, Chang M, Littell RC, Wu SS, Yin TM, Huang MR, Wang MX, and Casella G
A logistic mixture model for characterizing genetic
determinants causing differentiation in growth trajectories
GENETICAL RESEARCH 79 (3): 235-245 JUN 2002
Wu SS, Ma CX, Wu RL and Casella G
A hierarchical statistical model for estimating population properties of quantitative genes
BMC Genetics 3 (10): 2002 (This article is available
from http://www.biomedcentral.com/1471-2156/3/10)
Wu RL, Ma CX,
Painter I, Zeng ZB
Simultaneous Maximum Likelihood Estimation of Linkage and
Linkage Phases in Outcrossing Species
Theoretical Population Biology 61 (3): 349-363 2002
Wu RL, Ma CX,
Wu SS, Zeng ZB
Linkage mapping of sex-specific differences
GENETICAL RESEARCH 79 (1): 85-96 FEB 2002
Wu RL, Ma CX,
Casella G
Joint linkage and linkage disequilibrium mapping of
quantitative trait loci in natural populations
GENETICS 160 (2): 779-792 FEB 2002
Wu RL, Ma CX,
Zhu J, Casella G
Mapping epigenetic quantitative trait loci (QTL) altering a
developmental trajectory
GENOME 45 (1): 28-33 FEB 2002
Fang KT, Ma CX
Wrap-around L-2-discrepancy of random sampling, Latin
hypercube and uniform designs
J COMPLEXITY 17 (4): 608-624 DEC 2001
Wu SS, Wu RL, Ma CX, Zeng ZB, Yang, MCK, Casella G
A multivalent pairing model of linkage analysis in autotetraploids
GENETICS 159 (3): 1339-1350 NOV 2001
Fang KT, Ma CX,
Winker P
Centered L-2-discrepancy of random sampling and Latin
hypercube design, and construction of uniform designs
MATH COMPUT 71 (237): 275-296 2002
Ma CX, Fang KT, Lin DKJ
On the isomorphism of fractional factorial designs
J COMPLEXITY 17 (1): 86-97 MAR 2001
Ma CX, Fang KT
A note on generalized aberration in factorial designs
METRIKA 53 (1): 85-93 2001
Ma CX, Fang KT, Liski E
A new approach in constructing orthogonal and nearly
orthogonal arrays
METRIKA 50 (3): 255-268 2000
Fang KT, Lin DKJ,
Ma CX
On the construction of multi-level supersaturated designs
J STAT PLAN INFER 86 (1): 239-252 APR 15 2000
Research Projects
Ø Child Abuse and Neglect
Ø Analysis of Predictors of Healthy Outcomes for Medicaid Eligible Women, Their Infants and Young Children
Ø Experimental Design
Software
Web-based functional mapping software
Polyploid Mapping (Windows 95 or 2000)
Polyploid Mapping (Windows XP)
Sample Size Calculator for Barnard designs in clinical trial, two samples, two stages