The Human Hepatic Cytochrome P450 Expression Calculator

Age (x)        

Predicted Values and  Confidence Limits for Mean and for Predicted Value:

The numbers within the first set of parenthesis represents the confidence of the mean while the numbers within the second set of parenthesis represents the confidence interval for the population.

Age is limited to a maximum x = 20 years by current available data.

The CYP calculator is limited to x = 2.3 years for CYP3A7 as CYP3A7 expression has been shown to decrease after birth beyond level of detection in many individuals.

CYP2C19 = 2.5898 + 1.3071 * log ( x * 365)

CYP2C9 = 8.8611 - 0.36756 * x + 1.4799 * log ( x * 365)

CYP2E1 = 6.0189 + 5.9652 * log ( x * 365)

CYP3A4 = -8.3212 + 2.0401 * x + 4.1962 * log ( x * 365)

CYP3A5 = 3.2827 + 0.07205 * x + 0.08206 * log ( x * 365)

CYP3A7 = 162.2407 + 5.1011 * x - 25.7863 * log ( x * 365)

Note: x is in years in above formula.

Please contact Dr. James R Olson at the University at Buffalo, State University of New York, for more information or if you would like to contribute raw data to further refine the calculator.

References

Robert J. Foxenberga, Corie A. Ellisona, James B. Knaaka, Changxing Ma, James R. Olsona (2011). Cytochrome P450-specific human PBPK/PD models for the organophosphorus pesticides: Chlorpyrifos and parathion. Toxicology, Volume 285, Issues 1-2, Pages 57-66.

Wrighton, S. A., W. R. Brian, et al. (1990). "Studies on the expression and metabolic capabilities of human liver cytochrome P450IIIA5 (HLp3)." Molecular Pharmacology 38(2): 207-13.

Stevens, J. C., R. N. Hines, et al. (2003). "Developmental expression of the major human hepatic CYP3A enzymes." Journal of Pharmacology & Experimental Therapeutics 307(2): 573-82.

Koukouritaki, S. B., J. R. Manro, et al. (2004). "Developmental expression of human hepatic CYP2C9 and CYP2C19." Journal of Pharmacology & Experimental Therapeutics 308(3): 965-74.