Confidence intervals for difference of proportions from correlated bilateral data in ophthalmological studies
Zhengyu Yang and Chang-Xing Ma
Introduction
Bilateral correlated data often arise in ophthalmological studies,
where each subject may contribute results of two eyes to the analysis.
Measurements obtained from both eyes
of an individual are often highly correlated. Ignoring the correlation could lead
to incorrect inferences.
In this article, Wald and profile likelihood confidence intervals for difference of
proportions are adjusted for bilateral data, taking the intraclass correlation into account.
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