Book Chapters
4. Y. Wu, X. Zeng, Q. Gan. A compact surface plasmon resonance biosensor for sensitive detection of exosomal proteins for cancer diagnosis. Biomedical Engineering Technologies. Methods in Molecular Biology. Ossandon M. R., Baker H., Rasooly A. (Eds.), 2022, vol 2393, pp 314. ISBN: 9781071618028, Humana Press.
3. Q. Wang, Y. Wu. MicroRNA delivery by lipoplexes in lung cancer therapy. The World Scientific Encyclopedia of Nanomedicine and Bioengineering, Volume 3: Nanotechnology in Gene Delivery. Donglu Shi (Ed.), 2016. ISBN: 978-981-4667-65-4, World Scientific Publishers.
2. Y. Wu, D. Gallego-Perez, L. J. Lee. Microwell array mediated delivery of lipoplexes containing nucleic acids for enhanced therapeutic efficacy. Methods in Molecular Biology, Mouldy Sioud (Ed.). 2014, ISBN: 978-1-4939-1538-5, Springer/Humana Press
1. Y. Wu, A. Duong, L. J. Lee, B. E. Wyslouzil. Electrospray Production of Nanoparticles for Drug/Nucleic Acids Delivery. The Delivery of Nanoparticles, Abbass A. Hashim (Ed.), 2012, ISBN: 978-953-51-0615-9, InTech.
Peer-reviewed Papers
66. C. C. Hsu, Y. Yang, E. kannisto, X. Zeng, G. Yu, S. K. Patnaik, G. K. Dy, M. E. Reid, Q. Gan, Y. Wu. Simultaneous Detection of Tumor Derived Exosomal Protein-MicroRNA Pairs with an Exo-PROS Biosensor for Cancer Diagnosis. ACS Nano. 2023, 17(9): 8108-8122.
65. [L. Yan*, Y. Su*], I. Hsia, Y. Xu, V. K. Vincent-Chong, W. Mojica, M. Seshadri, R. Zhao, Y. Wu. Delivery of Anti-microRNA-21 by Lung-Targeted Liposomes for Pulmonary Fibrosis Treatment. Molecular Therapy Nucleic Acids. 2023, 32, 36-47.
64. [S. Tatiana*, L. Yan*], Y. Su, L. J. Rich, V. K. Vincent-Chong, H. Calkins, S. Pokharel, M. Petkovich, M. Seshadri, Y. Wu, P. A. Hershberger. A nanotherapeutic strategy to target drug tolerant cells and overcome EGFR tyrosine kinase inhibitor resistance in lung cancer. Cancer Communications. 2023. 43, 4, 503-507.
63. M. A. Mohamed, L. Yan, A. Shahini, N. Rajabian, A. Jafari, S. T. Andreadis, Y. Wu, C. Cheng. Well-Defined pH-Responsive Self-Assembled Block Copolymer for Effective Co-Delivery of Doxorubicin and Antisense Oligonucleotide to Breast Cancer Cells. ACS Applied BioMaterials. 2022, 5, 10, 4779-4792.
62. C. C. Hsu, Y. Wu. Recent Advances in Nanotechnology-Enabled Biosensors for Detection of Exosomes as New Cancer Liquid Biopsy. Experimental Biology and Medicine. 2022, 247, 23, 2152-2172.
61. L. Zhou, N. Zhang, C. C. Hsu, M. Singer, X. Zeng, Y. Li, H. Song, J. Jornet, Y. Wu, Q. Gan. Super-Resolution Displacement Spectroscopic Sensing over a Surface “Rainbow”. Engineering. 2022, 17, 75-81. (cover article)
60. N. C. Hait, A. Maiti, R. Wu, V. L. Andersen, C. C. Hsu, Y. Wu, D. G. Chapla, K. Takabe, M. E. Rusiniak, W. Bshara, J. Zhang, K. W. Moremen, J. T. Y. Lau. Extracellular sialyltransferase st6gal1 in breast tumor cell growth and invasiveness. Cancer Gene Therapy. 2022, 29, 1662-1675.
59. I. Jilishitz, J. L. Quiñones, P. Patel, G. Chen, J. Pasetsky, A. VanInwegen, S. Schoninger, M. P. Jogalekar, V. Tsiperson, L. Yan, Y. Wu, S. R. S. Gottesman, J. Somma, S. W. Blain. NP-ALT, a Liposomal:Peptide Drug, Blocks p27Kip1 Phosphorylation to Induce Oxidative Stress, Necroptosis, and Regression in Therapy-Resistant Breast Cancer Cells. Mol Cancer Res. 2021, 19(11), 1929-1945.
58. H. Sun, L. Yan, R. Zhang, J.F. Lovell, Y. Wu, C. Cheng. A Sulfobetaine Zwitterionic Polymer-Drug Conjugate for Multivalent Paclitaxel and Gemcitabine Co-Delivery. Biomaterials Science. 2021, 9, 5000-5010.
57. Y. Yang, E. Kannisto, S. K. Sanosh, M. E. Reid, L. Li, Y. Wu. Ultrafast detection of exosomal RNAs via cationic lipoplex nanoparticles in a micromixer biochip for cancer diagnosis. ASC Applied Nano Materials. 2021, 4, 3, 2806-2819 .
56. X. Miao, L. Yan, Y. Wu, P. Q. Liu. High-Sensitivity Nanophotonic Sensors with Passive Trapping of Analyte Molecules in Hot-Spots. Light: Science & Applications. 2021, 10, 5.
55. A. K. Sood, M. Nemeth, J. Wang, Y. Wu, S. Ganhhi. Opportunities for Antigen Discovery in Metastatic Breast Cancer. Frontiers in Immunology. 2020, 11: 570049.
54. C. Liu. E. Kannisto, G. Yu, Y. Yang, M. E. Reid, S. Patnaik, Y, Wu. Non-invasive Detection of Exosomal MicroRNAs via Tethered Cationic Lipoplex Nanoparticles (tCLN) Biochip for Lung Cancer Early Detection. Frontiers in Genetics. 2020, 11: 258.
53. S. L. Shu, Y. Yang, C. L. Allen, E. Hurley, K. H. Tung, H. Minderman, Y. Wu, M. S. Ernstoff. Purity and yield of melanoma exosomes are dependent on isolation method. Journal of Extracellular Vesicles. 2020, 9, 1692401
52. A. Jafari, L. Yan, M. A. Mohamed, Y. Wu, C. Cheng. Well-Defined Diblock Poly(ethylene glycol)-b-Poly(ε-caprolactone)-Based Polymer-Drug Conjugate Micelles for pH-Responsive Delivery of Doxorubicin. Materials. 2020, 13, 1510.
51. H. Sun, L. Yan, M. Y. Z. Chang, K. A. Carter, R. Zhang, L. Slyker, J. F. Lovell, Y. Wu, C. Cheng. A multifunctional biodegradable brush polymer-drug conjugate for paclitaxel/gemcitabine co-delivery and tumor imaging. Nanoscale Advances. 2019, 1, 2761-2771.
50. H. He, C. Liu, Y. Liu, X. Liu, Y. Wu, J. Fan, L. Zhao, Y. Cao. Mathematical modeling of the heterogeneous distributions of nanomedicines in solid tumors. European Journal of Pharmaceutics and Biopharmaceutics. 2019, 142, 153-164.
49. H He, D. Yuan, Y. Wu, Y. Cao. Pharmacokinetics and pharmacodynamics modeling and simulation systems to support the development and regulation of liposomal drugs. Pharmaceutics. 2019, 11 (3), 110.
48. D. Yuan, H. He, Y. Wu, J. Fan, Y. Cao. Physiologically based pharmacokinetic modeling of nanoparticles. Journal of Pharmaceutical Sciences. 2019, 108 (1), 58-72. (invited paper)
47. H. Sun, L. Yan, K. A. Carter, J. Zhang, J. Caserto, J. F. Lovell, Y. Wu, C. Cheng. Zwitterionic Crosslinked Biodegradable Nanocapsules for Cancer Imaging. Langmuir. 2019, 35(5): 1440-1449. (invited paper)
46. X. Zeng, Y. Yang, N. Zhang, D. Ji, X. Du, J. Jornet, Y. Wu. Q. Gan. Plasmonic interferometer array biochip as a new mobile medical device for cancer detection. IEEE Journal of Selected Topics in Quantum Electronics. 2019, 25 (1), 7201707. (invited paper)
45. Y. Yang, E. Kannisto, G. Yu, M. E. Reid, S. Patnaik, Y. Wu. A diagnostic immuno-biochip for selective exosome capture and exosomal RNA detection. ASC Applied Materials and Interfaces. 2018. 10 (50), 43375-43386.
44. Q. Wang, A. Masud, N. Aich, Y. Wu. In Vitro Pulmonary toxicity of Reduced Graphene Oxide-Nano Zero Valent Iron Nanohybrids and Comparison with Parent Material Attributes. ACS Sustainable Chemistry & Engineering. 2018. (invited paper)
43. C. Liu, T. Shaurova, S. Shoemaker, M. Petkovich, P. A. Hershberger, Y. Wu. Tumor targeted nanoparticles deliver a vitamin D-based drug payload for treatment of EGFR tyrosin kinase inhibitor-resistant lung cancer. Molecular Pharmaceutics. 2018. 15 (8): 3216-3226.
42. C. Liu, X. Zeng, Z. An, Y. Yang, M. Eisenbaum, X. Gu, J. M. Jornet, G. K. Grace, M. E. Reid, Q. Gan, Y. Wu. Sensitive detection of exosomal proteins via a compact surface plasmon resonance biosensor for cancer diagnosis. ACS Sensor. 2018, 3, 1471-1479.
41. C. Liu, D. Wang, Y. Zhan, L. Yan, Q. Lu, M. Y. Z. Chang, J. Luo, L. Wang, D. Du, Y. Lin, J. Xia, Y. Wu. Switchable Photoacoustic Imaging of Glutathione Using MnO2 Nanotubes for Cancer Diagnosis. ASC Applied Materials and Interfaces. 2018, 10 (51), 44231-44239.
40. S. L. Shu, Y. Yang, C. L. Allen, O. Maguire, H. Minderman, A. Sen, M. J. Ciesielski, K. A. Collins, P. J. Bush, P. Singh, X. Wang, M. Morgan, J. Qu, R. B. Bnkert, T. L. Whiteside, Y. Wu, M. S. Ernstoff. Metabolic reprogramming of stromal fibroblasts by melanoma exosome microRNA generates pre-metastatic microenvironments. Scientific Report. 2018, 8, 12905.
39. H. He, C. Liu, Y. Wu, X. Zhang, Y. Cao. A Multiscale physiologically-based pharmacokinetic model for doxorubicin to explore its mechanisms of cytotoxicity and cardiotoxicity. Pharmaceutical Research. 2018, 35(9):174.
38. C. Liu, Y. Yang, Y. Wu. Recent advances in exosomal protein detection via liquid biopsy biosensors for cancer screening, diagnosis and prognosis. The AAPS Journal. 2018, 20(2): 41.
37. H. Sun, M. Y. Z. Chang, W. Cheng, Q. Wang, A. Commisso, M. Capeling, Y. Wu, C. Chong. Biodegradable zwitterionic polymer and its conjugate with paclitaxel for sustained drug delivery. Acta Biomaterialia. 2017, 64: 290-300.
36. Q. Lu, D. Ericson, Y. Song, C. Zhu, R. Ye, S. Liu, J. Spernyak, D. Du, H. Li, Y. Wu, Y. Lin. MnO2 nanotubes-based nanosearchlight for imaging of multiple microRNAs in live cells. ACS Applied Materials & Interfaces. 2017, 9 (28), 23325-23332.
35. X. Zhang, Y. Wu, M. Zhang, J. Mao, Y. Wu, Y. Zhang, J. Yao, C. Xu, W. Guo, B. Yu. Sodium cholate enhanced polymeric micelle system for tumor-targeting delivery of paclitaxel. International Journal of Nanomedicine. 2017, 12, 8779-8799.
34. [Z. Chen*, Q. Wang*], M. Asmani, Y. Li, C. Liu, C. Li, J. M. Lippmann, Y. Wu, R. Zhao. Microtissue array to screen the impact of carbon nanotubes on lung cellular and tissue biomechanics. Scientific Reports. 2016, 6, 33104. (*: equal contribution)
33. D. Wang, Y. Wu, J. Xia. Photoacoustic tomography of the brain using nanoprobes. Neurophotonics. 2016, 3(1), 010901.
32. D. Gallego-Perez, L. Chang, J. Shi, J. Ma, S. H. Kim, X. Zhao, V. Malkoc, X. Wang, M. Minata, K. J. Kwak, Y. Wu, G. P. Lafyatis, W. Lu, D. J. Hansford, I. Nakano, L. J. Lee. HYPERLINK "http://pubs.acs.org/doi/abs/10.1021/acs.nanolett.6b00902" On-Chip Clonal Analysis of Glioma-Stem-Cell Motility and Therapy Resistance. Nano Letters. 2016, 16 (9), 5326-5332.
31. Y. Wu, J. Ma, P. Woods, N. Chesarino, C. Liu, L. J. Lee, S. P. Nana-Sinkam, I.C. Davis. Selective targeting of alveolar type II respiratory epithelial cells by anti-surfactant protein-C antibody-conjugated lipoplexes. Journal of Controlled Release. 2015, 203C, 140-149.
30. X. Zhao, X. Huang, X. Wang, Y. Wu, A. K. Eisfeld, S. Schwind, D. Gallego-Perez, P. E. Boukany, G. I. Marcucci, L. J. Lee. Nanochannel Electroporation as a Platform for Living Cell Interrogation in Acute Myeloid Leukemia. Advanced Science. 2015, 2, 1500111.
29. X. Zhao, Y. Wu, D. Gallego-Perez, K. J. Kwak, C. Gupta,X. Ouyang, L. J. Lee. Effect of Non-Endocytic Uptake of Nanoparticles on Human Bronchial Epithelial Cells. Analytical Chemistry. 2015, 87, 3208-3215.
28. A. Pulliero, Y. Wu, D. Fenoglio, A. Parodi, C. P. Soares, G. Filaci, L. J. Lee, S. P. Nana Sinkam, A. Izzotti. Nanoparticles increase the efficacy of cancer chemopreventive agents in cells exposed to cigarette smoke condensate. Carcinogenesis. 2015, 36, 368-377.
27. R. Mani, Y. Mao, F. W. Frissora, C. L. Chiang, J. Wang, Y, Zhao, Y. Wu, B. Yu, R. Yan, X. Mo, L. Yu, J. Flynn, J. Jones, L. Andritsos, S. Baskar, C. Rader, M. A. Phelps, C. S. Chen, R. J. Lee, J. C. Byrd, L. J. Lee, N. Muthusamy. Tumor antigen ROR1 targeted drug delivery mediated selective leukemic but not normal B cell cytotoxicity in chronic lymphocytic leukemia. Leukemia. 2015, 29, 346-355.
26. L. Alinari, K. V. Mahasenan, F. Yan, V. Karkhanis, J. H. Chung, E. M. Smith, C. Quinion, P. L. Smith, L. Kim, J. T. Patton, R. Lapalombella, B. Yu, Y. Wu, S. Roy, A. De Leo, S. Pileri, C. Agostinelli, L. Ayers, J. E. Bradner, S. Chen-Kiang, O. Elemento, T. Motiwala, S. Majumder, J. C. Byrd, S. Jacob, S. Sif, C. Li, R. A. Baiocchi. Selective inhibition of protein arginine methyltransferase 5 blocks iniation and maintenance of B-cell transformation. Blood. 2015, 125, 2530-2543.
25. B. Luo, H. Liang, S. ZHang, X. Qin, X. Liu, W. Liu, F. Zeng, Y. Wu, X. Yang. Novel lactoferrin-conjugated amphiphilic poly(aminoethyl ethylene phosphate)/poly(L-lactide) copolymer nano-bubbles for tumor-targeting ultrasonic imaging. International Journal of Nanomedicine. 2015, 10, 58055817.
24. L. J. Wang, L. Li, J. Yu, Y. Wu, H. He, X. Ouyang, X. Zhao, Y.C. Yen, L. J. Lee, Large-area graphene coating via superhydrophilic-assisted electro-hydrodynamic spraying deposition. Carbon. 2014, 79, 294-301.
23. B. Binjawadagi, V. Dwivedi, C. Manickam, K. Ouyang, Y. Wu, L. J. Lee, J. B. Torrelles, G. J. Renukaradhya. Adjuvanted poly (lactic-co-glycolic) acid nanoparticle-entrapped inactivated porcine reproductive and respiratory syndrome virus vaccine elicits cross-protective immune response in pigs. International Journal of Nanomedicine. 2014; 9: 679-694.
22. [P. E. Boukany*, Y. Wu *], X. Zhao, K.J. Kwak, P.J. Glazer, K. Leong, L. J. Lee. Nonendocytic delivery of lipoplex nanoparticles into living cells using nanochannel electroporation. Advanced Healthcare Materials. 2014, 3, 682-689. (*: equal contribution) (Inner cover article, highlighted on MaterialsViews)
21. M. C. Terp, Y. Wu, B. Yu, K. J. Kwak, L. J. Lee. Microwell array guided assembly of lipoplex nanoparticles containing siRNA. Langmuir. 2014, 30, 2873-2878.
20. Y. Mao, J. Wang, Y. Zhao, Y. Wu, K. J. Kwak, C. Chen, J. C. Byrd, R. J. Lee, M. A. Phelps, L. J. Lee, N. Muthusamy. A novel liposomal formulation of FTY720 (Fingolimod) for promising enhanced targeted delivery. Nanomedicine: Nanotechnology, Biology and Medicine. 2014, 10: 393-400.
19. K. Gao, L. Li, L. He, K. Hinkle, Y. Wu, J. Ma, L. Chang, X. Zhao, D. G. Perez, S. Eckardt, J. Mclaughlin, B. Liu, D. F. Farson, L. J. Lee. Design of a microchannel-nanochannel-microchannel array based nanoelectroporation system for precise gene transfection. Small. 2014, 10: 1015-1023.
18. Y. Wu, K. J. Kwak, K. Agarwal, A. Marras, C. Wang, Y. Mao, X. Huang, J. Ma, B. Yu, R. Lee, A. Vachani, G. Marcucci, J. Byrd, N. Muthusamy, K. Huang, C. E. Castro, M. Paulaitis, S. P. Nana-Sinkam , L. J. Lee. Detection of extracellular RNAs in cancer and viral infection via tethered cationic lipoplex nanoparticles containing molecular beacons. Analytical Chemistry. 2013, 85: 11265-11274.
17. Y. Wu, M. C. Terp, K. J. Kwak, D. Gallego-Perez, S. P. Nana-Sinkam, L. J. Lee. Surface mediated nucleic acids delivery by lipoplexes synthesized in microwell array. Small. 2013, 9, 2358-2367.
16. Y. Wu, M. Crawford, Y. Mao, R. Lee, T. S. Elton, L. J. Lee, S. P. Nana-Sinkam. Therapeutic delivery of microRNA-29b by cationic lipoplexes for lung cancer. Molecular Therapy Nucleic Acids. 2013, 2, e84.
15. Z. Fei, Y. Wu, S. Sharma, D. Gallego-Perez, N. Higuita-Castro, D. Hansford, J. J. Lannutti, L. J. Lee. Gene delivery to cultured embryonic stem cells using nanofiber-based sandwich electroporation. Analytical Chemistry. 2013, 85, 1401-1407.
14. Y. Wu, L. Li, Y. Mao, L. J. Lee. Static micromixer - coaxial electrospray synthesis of theranostic lipoplexes. ACS Nano. 2012, 6, 2245-2252.
13. L. P. Ganesan, J. Kim, Y. Wu, S. Mohanty, G. S. Phillips, D. J. Birmingham, J. M. Robinson, C. L. Anderson. FcγRIIb on liver sinusoidal endothelium clears small immune complexes. The Journal of Immunology. 2012, 189, 4981-4988.
12. B. Yu, S. Hsu, C. Zhou, X. Wang, M. C. Terp, Y. Wu, L. Teng, Y. Mao, F. Wang, W. Xue, S. T. Jacob, K. Ghoshal, R. J. Lee, L. J. Lee. Lipid nanoparticles for hepatic delivery of small interfering RNA Biomaterials. 2012, 33, 5924-5934.
11. Y. Wu, M. Crawford, B. Yu, Y. Mao, S. P. Nana-Sinkam, L. J. Lee. MicroRNA delivery by cationic lipoplexes for lung cancer therapy. Molecular Pharmaceutics. 2011, 8, 1381-1389.
10. Y. Wu, Y. Ho, Y. Mao, X. Wang, B. Yu, K. Leong, L. J. Lee. Uptake and intracellular fate of multifunctional nanoparticles: a comparison between lipoplexes and polyplexes via quantum dots-FRET. Molecular Pharmaceutics. 2011, 8, 1662-1668.
9. Y. Wu, N. Ma, J. J. Chalmers, B. E. Wyslouzil, E. L. McCormick, S. Casnocha. Enhanced productivity of NS0 cells in fed-batch culture with cholesterol nanoparticle supplementation. Biotechnology Progress. 2011, 27, 796-802.
8. P. E. Boukany, A. Morss, W. Liao, B. Henslee, X. Zhang, B. Yu, X. Wang, Y. Wu, H. Jung, L. Li, K. Gao, X. Hu, X. Zhao, O. Hemminger, W. Lu, G. P. Lafyatis, L. J. Lee. Nanochannel electroporation delivers precise amounts of biomolecules into living cells. Nature Nanotechnology. 2011, 6, 747-754. Research highlight in Nature Methods. 2011, 8, 996-997.
7. Y. C. Lim, J. Johnson, Z. Fei, Y. Wu, D. F. Farson, J. J. Lannutti, H. W. Choi, L. J. Lee. Micropatterning and characterization of electrospun poly(ε-caprolactone)/gelatin nanofiber tissue scaffolds by femtosecond laser ablation for tissue engineering applications. Biotechnology and Bioengineering. 2011, 108, 116-126.
6. B. Yu, J. Zhu, W. Xue, Y. Wu, X. Huang, L. J. Lee, R. J. Lee. Microfluidic assembly of lipid-based oligonucleotide nanoparticles. Anticancer Research. 2011, 31, 771-776.
5. X. Wang, B. Yu, Y. Wu, R. J. Lee, L. J. Lee. Efficient down-regulation of CDK4 by novel lipid nanoparticle-mediated siRNA delivery. Anticancer Research. 2011, 31, 1619-1626.
4. Y. Wu, Z. Fei, L. J. Lee, B. E. Wyslouzil. Electrohydrodynamic spraying of DNA/polyethylenimine polyplexes for nonviral gene delivery. Biotechnology and Bioengineering. 2010, 105, 834-841.
3. D. Liang, H. C. Allen, G. S. Frankel, Z. Y. Chen, R. G. Kelly, Y. Wu, B.E. Wyslouzil. Effects of sodium chloride particles on atmospheric corrosion of silver in the presence of ozone, UV, and relative humidity. Journal of Electrochemical Society. 2010, 157, C146-C156.
2. Y. Wu, B. Yu, A. Jackson, W. Zha, L. J. Lee, B. E. Wyslouzil. Coaxile electrohydrodynamic spraying: a novel one-step technique to prepare oligodeoxynucleotide encapsulated lipoplex nanoparticles. Molecular Pharmaceutics. 2009, 6, 1371-1379.
1. Y. Wu, J. J. Chalmers, B. E. Wyslouzil. The use of electrohydrodynamic spraying to disperse hydrophobic compounds in aqueous media. Aerosol Science and Technology. 2009, 43, 902-910.
4. Y. Wu, X. Zeng, Q. Gan. A compact surface plasmon resonance biosensor for sensitive detection of exosomal proteins for cancer diagnosis. Biomedical Engineering Technologies. Methods in Molecular Biology. Ossandon M. R., Baker H., Rasooly A. (Eds.), 2022, vol 2393, pp 314. ISBN: 9781071618028, Humana Press.
3. Q. Wang, Y. Wu. MicroRNA delivery by lipoplexes in lung cancer therapy. The World Scientific Encyclopedia of Nanomedicine and Bioengineering, Volume 3: Nanotechnology in Gene Delivery. Donglu Shi (Ed.), 2016. ISBN: 978-981-4667-65-4, World Scientific Publishers.
2. Y. Wu, D. Gallego-Perez, L. J. Lee. Microwell array mediated delivery of lipoplexes containing nucleic acids for enhanced therapeutic efficacy. Methods in Molecular Biology, Mouldy Sioud (Ed.). 2014, ISBN: 978-1-4939-1538-5, Springer/Humana Press
1. Y. Wu, A. Duong, L. J. Lee, B. E. Wyslouzil. Electrospray Production of Nanoparticles for Drug/Nucleic Acids Delivery. The Delivery of Nanoparticles, Abbass A. Hashim (Ed.), 2012, ISBN: 978-953-51-0615-9, InTech.
Peer-reviewed Papers
66. C. C. Hsu, Y. Yang, E. kannisto, X. Zeng, G. Yu, S. K. Patnaik, G. K. Dy, M. E. Reid, Q. Gan, Y. Wu. Simultaneous Detection of Tumor Derived Exosomal Protein-MicroRNA Pairs with an Exo-PROS Biosensor for Cancer Diagnosis. ACS Nano. 2023, 17(9): 8108-8122.
65. [L. Yan*, Y. Su*], I. Hsia, Y. Xu, V. K. Vincent-Chong, W. Mojica, M. Seshadri, R. Zhao, Y. Wu. Delivery of Anti-microRNA-21 by Lung-Targeted Liposomes for Pulmonary Fibrosis Treatment. Molecular Therapy Nucleic Acids. 2023, 32, 36-47.
64. [S. Tatiana*, L. Yan*], Y. Su, L. J. Rich, V. K. Vincent-Chong, H. Calkins, S. Pokharel, M. Petkovich, M. Seshadri, Y. Wu, P. A. Hershberger. A nanotherapeutic strategy to target drug tolerant cells and overcome EGFR tyrosine kinase inhibitor resistance in lung cancer. Cancer Communications. 2023. 43, 4, 503-507.
63. M. A. Mohamed, L. Yan, A. Shahini, N. Rajabian, A. Jafari, S. T. Andreadis, Y. Wu, C. Cheng. Well-Defined pH-Responsive Self-Assembled Block Copolymer for Effective Co-Delivery of Doxorubicin and Antisense Oligonucleotide to Breast Cancer Cells. ACS Applied BioMaterials. 2022, 5, 10, 4779-4792.
62. C. C. Hsu, Y. Wu. Recent Advances in Nanotechnology-Enabled Biosensors for Detection of Exosomes as New Cancer Liquid Biopsy. Experimental Biology and Medicine. 2022, 247, 23, 2152-2172.
61. L. Zhou, N. Zhang, C. C. Hsu, M. Singer, X. Zeng, Y. Li, H. Song, J. Jornet, Y. Wu, Q. Gan. Super-Resolution Displacement Spectroscopic Sensing over a Surface “Rainbow”. Engineering. 2022, 17, 75-81. (cover article)
60. N. C. Hait, A. Maiti, R. Wu, V. L. Andersen, C. C. Hsu, Y. Wu, D. G. Chapla, K. Takabe, M. E. Rusiniak, W. Bshara, J. Zhang, K. W. Moremen, J. T. Y. Lau. Extracellular sialyltransferase st6gal1 in breast tumor cell growth and invasiveness. Cancer Gene Therapy. 2022, 29, 1662-1675.
59. I. Jilishitz, J. L. Quiñones, P. Patel, G. Chen, J. Pasetsky, A. VanInwegen, S. Schoninger, M. P. Jogalekar, V. Tsiperson, L. Yan, Y. Wu, S. R. S. Gottesman, J. Somma, S. W. Blain. NP-ALT, a Liposomal:Peptide Drug, Blocks p27Kip1 Phosphorylation to Induce Oxidative Stress, Necroptosis, and Regression in Therapy-Resistant Breast Cancer Cells. Mol Cancer Res. 2021, 19(11), 1929-1945.
58. H. Sun, L. Yan, R. Zhang, J.F. Lovell, Y. Wu, C. Cheng. A Sulfobetaine Zwitterionic Polymer-Drug Conjugate for Multivalent Paclitaxel and Gemcitabine Co-Delivery. Biomaterials Science. 2021, 9, 5000-5010.
57. Y. Yang, E. Kannisto, S. K. Sanosh, M. E. Reid, L. Li, Y. Wu. Ultrafast detection of exosomal RNAs via cationic lipoplex nanoparticles in a micromixer biochip for cancer diagnosis. ASC Applied Nano Materials. 2021, 4, 3, 2806-2819 .
56. X. Miao, L. Yan, Y. Wu, P. Q. Liu. High-Sensitivity Nanophotonic Sensors with Passive Trapping of Analyte Molecules in Hot-Spots. Light: Science & Applications. 2021, 10, 5.
55. A. K. Sood, M. Nemeth, J. Wang, Y. Wu, S. Ganhhi. Opportunities for Antigen Discovery in Metastatic Breast Cancer. Frontiers in Immunology. 2020, 11: 570049.
54. C. Liu. E. Kannisto, G. Yu, Y. Yang, M. E. Reid, S. Patnaik, Y, Wu. Non-invasive Detection of Exosomal MicroRNAs via Tethered Cationic Lipoplex Nanoparticles (tCLN) Biochip for Lung Cancer Early Detection. Frontiers in Genetics. 2020, 11: 258.
53. S. L. Shu, Y. Yang, C. L. Allen, E. Hurley, K. H. Tung, H. Minderman, Y. Wu, M. S. Ernstoff. Purity and yield of melanoma exosomes are dependent on isolation method. Journal of Extracellular Vesicles. 2020, 9, 1692401
52. A. Jafari, L. Yan, M. A. Mohamed, Y. Wu, C. Cheng. Well-Defined Diblock Poly(ethylene glycol)-b-Poly(ε-caprolactone)-Based Polymer-Drug Conjugate Micelles for pH-Responsive Delivery of Doxorubicin. Materials. 2020, 13, 1510.
51. H. Sun, L. Yan, M. Y. Z. Chang, K. A. Carter, R. Zhang, L. Slyker, J. F. Lovell, Y. Wu, C. Cheng. A multifunctional biodegradable brush polymer-drug conjugate for paclitaxel/gemcitabine co-delivery and tumor imaging. Nanoscale Advances. 2019, 1, 2761-2771.
50. H. He, C. Liu, Y. Liu, X. Liu, Y. Wu, J. Fan, L. Zhao, Y. Cao. Mathematical modeling of the heterogeneous distributions of nanomedicines in solid tumors. European Journal of Pharmaceutics and Biopharmaceutics. 2019, 142, 153-164.
49. H He, D. Yuan, Y. Wu, Y. Cao. Pharmacokinetics and pharmacodynamics modeling and simulation systems to support the development and regulation of liposomal drugs. Pharmaceutics. 2019, 11 (3), 110.
48. D. Yuan, H. He, Y. Wu, J. Fan, Y. Cao. Physiologically based pharmacokinetic modeling of nanoparticles. Journal of Pharmaceutical Sciences. 2019, 108 (1), 58-72. (invited paper)
47. H. Sun, L. Yan, K. A. Carter, J. Zhang, J. Caserto, J. F. Lovell, Y. Wu, C. Cheng. Zwitterionic Crosslinked Biodegradable Nanocapsules for Cancer Imaging. Langmuir. 2019, 35(5): 1440-1449. (invited paper)
46. X. Zeng, Y. Yang, N. Zhang, D. Ji, X. Du, J. Jornet, Y. Wu. Q. Gan. Plasmonic interferometer array biochip as a new mobile medical device for cancer detection. IEEE Journal of Selected Topics in Quantum Electronics. 2019, 25 (1), 7201707. (invited paper)
45. Y. Yang, E. Kannisto, G. Yu, M. E. Reid, S. Patnaik, Y. Wu. A diagnostic immuno-biochip for selective exosome capture and exosomal RNA detection. ASC Applied Materials and Interfaces. 2018. 10 (50), 43375-43386.
44. Q. Wang, A. Masud, N. Aich, Y. Wu. In Vitro Pulmonary toxicity of Reduced Graphene Oxide-Nano Zero Valent Iron Nanohybrids and Comparison with Parent Material Attributes. ACS Sustainable Chemistry & Engineering. 2018. (invited paper)
43. C. Liu, T. Shaurova, S. Shoemaker, M. Petkovich, P. A. Hershberger, Y. Wu. Tumor targeted nanoparticles deliver a vitamin D-based drug payload for treatment of EGFR tyrosin kinase inhibitor-resistant lung cancer. Molecular Pharmaceutics. 2018. 15 (8): 3216-3226.
42. C. Liu, X. Zeng, Z. An, Y. Yang, M. Eisenbaum, X. Gu, J. M. Jornet, G. K. Grace, M. E. Reid, Q. Gan, Y. Wu. Sensitive detection of exosomal proteins via a compact surface plasmon resonance biosensor for cancer diagnosis. ACS Sensor. 2018, 3, 1471-1479.
41. C. Liu, D. Wang, Y. Zhan, L. Yan, Q. Lu, M. Y. Z. Chang, J. Luo, L. Wang, D. Du, Y. Lin, J. Xia, Y. Wu. Switchable Photoacoustic Imaging of Glutathione Using MnO2 Nanotubes for Cancer Diagnosis. ASC Applied Materials and Interfaces. 2018, 10 (51), 44231-44239.
40. S. L. Shu, Y. Yang, C. L. Allen, O. Maguire, H. Minderman, A. Sen, M. J. Ciesielski, K. A. Collins, P. J. Bush, P. Singh, X. Wang, M. Morgan, J. Qu, R. B. Bnkert, T. L. Whiteside, Y. Wu, M. S. Ernstoff. Metabolic reprogramming of stromal fibroblasts by melanoma exosome microRNA generates pre-metastatic microenvironments. Scientific Report. 2018, 8, 12905.
39. H. He, C. Liu, Y. Wu, X. Zhang, Y. Cao. A Multiscale physiologically-based pharmacokinetic model for doxorubicin to explore its mechanisms of cytotoxicity and cardiotoxicity. Pharmaceutical Research. 2018, 35(9):174.
38. C. Liu, Y. Yang, Y. Wu. Recent advances in exosomal protein detection via liquid biopsy biosensors for cancer screening, diagnosis and prognosis. The AAPS Journal. 2018, 20(2): 41.
37. H. Sun, M. Y. Z. Chang, W. Cheng, Q. Wang, A. Commisso, M. Capeling, Y. Wu, C. Chong. Biodegradable zwitterionic polymer and its conjugate with paclitaxel for sustained drug delivery. Acta Biomaterialia. 2017, 64: 290-300.
36. Q. Lu, D. Ericson, Y. Song, C. Zhu, R. Ye, S. Liu, J. Spernyak, D. Du, H. Li, Y. Wu, Y. Lin. MnO2 nanotubes-based nanosearchlight for imaging of multiple microRNAs in live cells. ACS Applied Materials & Interfaces. 2017, 9 (28), 23325-23332.
35. X. Zhang, Y. Wu, M. Zhang, J. Mao, Y. Wu, Y. Zhang, J. Yao, C. Xu, W. Guo, B. Yu. Sodium cholate enhanced polymeric micelle system for tumor-targeting delivery of paclitaxel. International Journal of Nanomedicine. 2017, 12, 8779-8799.
34. [Z. Chen*, Q. Wang*], M. Asmani, Y. Li, C. Liu, C. Li, J. M. Lippmann, Y. Wu, R. Zhao. Microtissue array to screen the impact of carbon nanotubes on lung cellular and tissue biomechanics. Scientific Reports. 2016, 6, 33104. (*: equal contribution)
33. D. Wang, Y. Wu, J. Xia. Photoacoustic tomography of the brain using nanoprobes. Neurophotonics. 2016, 3(1), 010901.
32. D. Gallego-Perez, L. Chang, J. Shi, J. Ma, S. H. Kim, X. Zhao, V. Malkoc, X. Wang, M. Minata, K. J. Kwak, Y. Wu, G. P. Lafyatis, W. Lu, D. J. Hansford, I. Nakano, L. J. Lee. HYPERLINK "http://pubs.acs.org/doi/abs/10.1021/acs.nanolett.6b00902" On-Chip Clonal Analysis of Glioma-Stem-Cell Motility and Therapy Resistance. Nano Letters. 2016, 16 (9), 5326-5332.
31. Y. Wu, J. Ma, P. Woods, N. Chesarino, C. Liu, L. J. Lee, S. P. Nana-Sinkam, I.C. Davis. Selective targeting of alveolar type II respiratory epithelial cells by anti-surfactant protein-C antibody-conjugated lipoplexes. Journal of Controlled Release. 2015, 203C, 140-149.
30. X. Zhao, X. Huang, X. Wang, Y. Wu, A. K. Eisfeld, S. Schwind, D. Gallego-Perez, P. E. Boukany, G. I. Marcucci, L. J. Lee. Nanochannel Electroporation as a Platform for Living Cell Interrogation in Acute Myeloid Leukemia. Advanced Science. 2015, 2, 1500111.
29. X. Zhao, Y. Wu, D. Gallego-Perez, K. J. Kwak, C. Gupta,X. Ouyang, L. J. Lee. Effect of Non-Endocytic Uptake of Nanoparticles on Human Bronchial Epithelial Cells. Analytical Chemistry. 2015, 87, 3208-3215.
28. A. Pulliero, Y. Wu, D. Fenoglio, A. Parodi, C. P. Soares, G. Filaci, L. J. Lee, S. P. Nana Sinkam, A. Izzotti. Nanoparticles increase the efficacy of cancer chemopreventive agents in cells exposed to cigarette smoke condensate. Carcinogenesis. 2015, 36, 368-377.
27. R. Mani, Y. Mao, F. W. Frissora, C. L. Chiang, J. Wang, Y, Zhao, Y. Wu, B. Yu, R. Yan, X. Mo, L. Yu, J. Flynn, J. Jones, L. Andritsos, S. Baskar, C. Rader, M. A. Phelps, C. S. Chen, R. J. Lee, J. C. Byrd, L. J. Lee, N. Muthusamy. Tumor antigen ROR1 targeted drug delivery mediated selective leukemic but not normal B cell cytotoxicity in chronic lymphocytic leukemia. Leukemia. 2015, 29, 346-355.
26. L. Alinari, K. V. Mahasenan, F. Yan, V. Karkhanis, J. H. Chung, E. M. Smith, C. Quinion, P. L. Smith, L. Kim, J. T. Patton, R. Lapalombella, B. Yu, Y. Wu, S. Roy, A. De Leo, S. Pileri, C. Agostinelli, L. Ayers, J. E. Bradner, S. Chen-Kiang, O. Elemento, T. Motiwala, S. Majumder, J. C. Byrd, S. Jacob, S. Sif, C. Li, R. A. Baiocchi. Selective inhibition of protein arginine methyltransferase 5 blocks iniation and maintenance of B-cell transformation. Blood. 2015, 125, 2530-2543.
25. B. Luo, H. Liang, S. ZHang, X. Qin, X. Liu, W. Liu, F. Zeng, Y. Wu, X. Yang. Novel lactoferrin-conjugated amphiphilic poly(aminoethyl ethylene phosphate)/poly(L-lactide) copolymer nano-bubbles for tumor-targeting ultrasonic imaging. International Journal of Nanomedicine. 2015, 10, 58055817.
24. L. J. Wang, L. Li, J. Yu, Y. Wu, H. He, X. Ouyang, X. Zhao, Y.C. Yen, L. J. Lee, Large-area graphene coating via superhydrophilic-assisted electro-hydrodynamic spraying deposition. Carbon. 2014, 79, 294-301.
23. B. Binjawadagi, V. Dwivedi, C. Manickam, K. Ouyang, Y. Wu, L. J. Lee, J. B. Torrelles, G. J. Renukaradhya. Adjuvanted poly (lactic-co-glycolic) acid nanoparticle-entrapped inactivated porcine reproductive and respiratory syndrome virus vaccine elicits cross-protective immune response in pigs. International Journal of Nanomedicine. 2014; 9: 679-694.
22. [P. E. Boukany*, Y. Wu *], X. Zhao, K.J. Kwak, P.J. Glazer, K. Leong, L. J. Lee. Nonendocytic delivery of lipoplex nanoparticles into living cells using nanochannel electroporation. Advanced Healthcare Materials. 2014, 3, 682-689. (*: equal contribution) (Inner cover article, highlighted on MaterialsViews)
21. M. C. Terp, Y. Wu, B. Yu, K. J. Kwak, L. J. Lee. Microwell array guided assembly of lipoplex nanoparticles containing siRNA. Langmuir. 2014, 30, 2873-2878.
20. Y. Mao, J. Wang, Y. Zhao, Y. Wu, K. J. Kwak, C. Chen, J. C. Byrd, R. J. Lee, M. A. Phelps, L. J. Lee, N. Muthusamy. A novel liposomal formulation of FTY720 (Fingolimod) for promising enhanced targeted delivery. Nanomedicine: Nanotechnology, Biology and Medicine. 2014, 10: 393-400.
19. K. Gao, L. Li, L. He, K. Hinkle, Y. Wu, J. Ma, L. Chang, X. Zhao, D. G. Perez, S. Eckardt, J. Mclaughlin, B. Liu, D. F. Farson, L. J. Lee. Design of a microchannel-nanochannel-microchannel array based nanoelectroporation system for precise gene transfection. Small. 2014, 10: 1015-1023.
18. Y. Wu, K. J. Kwak, K. Agarwal, A. Marras, C. Wang, Y. Mao, X. Huang, J. Ma, B. Yu, R. Lee, A. Vachani, G. Marcucci, J. Byrd, N. Muthusamy, K. Huang, C. E. Castro, M. Paulaitis, S. P. Nana-Sinkam , L. J. Lee. Detection of extracellular RNAs in cancer and viral infection via tethered cationic lipoplex nanoparticles containing molecular beacons. Analytical Chemistry. 2013, 85: 11265-11274.
17. Y. Wu, M. C. Terp, K. J. Kwak, D. Gallego-Perez, S. P. Nana-Sinkam, L. J. Lee. Surface mediated nucleic acids delivery by lipoplexes synthesized in microwell array. Small. 2013, 9, 2358-2367.
16. Y. Wu, M. Crawford, Y. Mao, R. Lee, T. S. Elton, L. J. Lee, S. P. Nana-Sinkam. Therapeutic delivery of microRNA-29b by cationic lipoplexes for lung cancer. Molecular Therapy Nucleic Acids. 2013, 2, e84.
15. Z. Fei, Y. Wu, S. Sharma, D. Gallego-Perez, N. Higuita-Castro, D. Hansford, J. J. Lannutti, L. J. Lee. Gene delivery to cultured embryonic stem cells using nanofiber-based sandwich electroporation. Analytical Chemistry. 2013, 85, 1401-1407.
14. Y. Wu, L. Li, Y. Mao, L. J. Lee. Static micromixer - coaxial electrospray synthesis of theranostic lipoplexes. ACS Nano. 2012, 6, 2245-2252.
13. L. P. Ganesan, J. Kim, Y. Wu, S. Mohanty, G. S. Phillips, D. J. Birmingham, J. M. Robinson, C. L. Anderson. FcγRIIb on liver sinusoidal endothelium clears small immune complexes. The Journal of Immunology. 2012, 189, 4981-4988.
12. B. Yu, S. Hsu, C. Zhou, X. Wang, M. C. Terp, Y. Wu, L. Teng, Y. Mao, F. Wang, W. Xue, S. T. Jacob, K. Ghoshal, R. J. Lee, L. J. Lee. Lipid nanoparticles for hepatic delivery of small interfering RNA Biomaterials. 2012, 33, 5924-5934.
11. Y. Wu, M. Crawford, B. Yu, Y. Mao, S. P. Nana-Sinkam, L. J. Lee. MicroRNA delivery by cationic lipoplexes for lung cancer therapy. Molecular Pharmaceutics. 2011, 8, 1381-1389.
10. Y. Wu, Y. Ho, Y. Mao, X. Wang, B. Yu, K. Leong, L. J. Lee. Uptake and intracellular fate of multifunctional nanoparticles: a comparison between lipoplexes and polyplexes via quantum dots-FRET. Molecular Pharmaceutics. 2011, 8, 1662-1668.
9. Y. Wu, N. Ma, J. J. Chalmers, B. E. Wyslouzil, E. L. McCormick, S. Casnocha. Enhanced productivity of NS0 cells in fed-batch culture with cholesterol nanoparticle supplementation. Biotechnology Progress. 2011, 27, 796-802.
8. P. E. Boukany, A. Morss, W. Liao, B. Henslee, X. Zhang, B. Yu, X. Wang, Y. Wu, H. Jung, L. Li, K. Gao, X. Hu, X. Zhao, O. Hemminger, W. Lu, G. P. Lafyatis, L. J. Lee. Nanochannel electroporation delivers precise amounts of biomolecules into living cells. Nature Nanotechnology. 2011, 6, 747-754. Research highlight in Nature Methods. 2011, 8, 996-997.
7. Y. C. Lim, J. Johnson, Z. Fei, Y. Wu, D. F. Farson, J. J. Lannutti, H. W. Choi, L. J. Lee. Micropatterning and characterization of electrospun poly(ε-caprolactone)/gelatin nanofiber tissue scaffolds by femtosecond laser ablation for tissue engineering applications. Biotechnology and Bioengineering. 2011, 108, 116-126.
6. B. Yu, J. Zhu, W. Xue, Y. Wu, X. Huang, L. J. Lee, R. J. Lee. Microfluidic assembly of lipid-based oligonucleotide nanoparticles. Anticancer Research. 2011, 31, 771-776.
5. X. Wang, B. Yu, Y. Wu, R. J. Lee, L. J. Lee. Efficient down-regulation of CDK4 by novel lipid nanoparticle-mediated siRNA delivery. Anticancer Research. 2011, 31, 1619-1626.
4. Y. Wu, Z. Fei, L. J. Lee, B. E. Wyslouzil. Electrohydrodynamic spraying of DNA/polyethylenimine polyplexes for nonviral gene delivery. Biotechnology and Bioengineering. 2010, 105, 834-841.
3. D. Liang, H. C. Allen, G. S. Frankel, Z. Y. Chen, R. G. Kelly, Y. Wu, B.E. Wyslouzil. Effects of sodium chloride particles on atmospheric corrosion of silver in the presence of ozone, UV, and relative humidity. Journal of Electrochemical Society. 2010, 157, C146-C156.
2. Y. Wu, B. Yu, A. Jackson, W. Zha, L. J. Lee, B. E. Wyslouzil. Coaxile electrohydrodynamic spraying: a novel one-step technique to prepare oligodeoxynucleotide encapsulated lipoplex nanoparticles. Molecular Pharmaceutics. 2009, 6, 1371-1379.
1. Y. Wu, J. J. Chalmers, B. E. Wyslouzil. The use of electrohydrodynamic spraying to disperse hydrophobic compounds in aqueous media. Aerosol Science and Technology. 2009, 43, 902-910.
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Engineered Theranostics Laboratory