Publications and Presentations

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:: Research Publications 2000 - 2004

(70) J. P. Richard and D. A. McCall, "Solvent Deuterium Isotope Effect on the Binding of b‑D-Galactopyranosyl Derivatives to b-Galactosidase (Escherichia coli, lac Z) ", Bioorganic Chemistry, 8, 49-56 (2000).

(71) J. P. Richard, M. M. Toteva and J. Crugeiras, "Structure-Reactivity Relationships and Intrinsic Reaction Barriers for Nucleophile Additions to a Quinone Methide: A Strongly Resonance-Stabilized Carbocation", Journal of the American Chemical Society, 122, 1664-1774 (2000).

(72) J. P. Richard and Y. Tsuji, "Dynamics for Reaction of an Ion Pair in Aqueous Solution: The Rate Constant for Ion Pair Reorganization", Journal of the American Chemical Society, 122, 3963-3964 (2000).

(73) A. Rios, T. L. Amyes and J. P. Richard, "Formation and Stability of Organic Zwitterions in Aqueous Solution: Enolates of the Amino Acid Glycine and its Derivatives", Journal of the American Chemical Society, 122, 9373-9385 (2000).

(74) M. M. Toteva and J. P. Richard, "Structure-Reactivity Relationships for Addition of Sulfur Nucleophiles to Electrophilic Carbon: Resonance, Polarization and Steric/Electrostatic Effects", Journal of the American Chemical Society, 122, 11073-11084 (2000).

(75) R. W. Nagorski and J. P. Richard, "Mechanistic Imperatives for Aldose-Ketose Isomerization in Water: Specific, General Base- and Metal Ion-Catalyzed Isomerization of Glyceraldehyde with Proton and Hydride Transfer", Journal of the American Chemical Society, 123, 794-802 (2001).

(76) Y. Tsuji, T. Mori, J. P. Richard, T. L. Amyes, M. Fujio and Y. Tsuno, "Dynamics for Reaction of an Ion Pair in Aqueous Solution: Reactivity of Carboxylate Anions in Bimolecular Carbocation-Nucleophile Addition and Unimolecular Ion Pair Collapse", Organic Letters, 3, 1237-1240 (2001).

(77) J. P. Richard, R. E. Huber and D. A. McCall, "Effect of an E461G Mutation of b‑Galactosidase (Escherichia coli, lac Z) on pL Rate Profiles and Solvent Deuterium Isotope Effects", Bioorganic Chemistry, 8, 146-155 (2001).

(78) M. M. Toteva and J. P. Richard, "Deprotonation of the a-(N,N-Dimethylcarbamoyl)-a-methyl-4-methoxybenzyl Carbocation by Alkanecarboxylate and Halide Ions", Journal of the Chemical Society, Perkin Transactions 2, 1167-1173 (2001).

(79) J. P. Richard, M. M. Toteva and T. L. Amyes, "What is the Stabilizing Interaction with Nucleophilic Solvents in the Transition State for Solvolysis of Tertiary Derivatives: Nucleophilic Solvent Participation or Nucleophilic Solvation?" Organic Letters, 3, 2225-2228 (2001).

(80) A. Rios, J. Crugeiras, T. L. Amyes and J. P. Richard, "Glycine Enolates: The Large Effect of Iminium Ion Formation on a-Amino Carbon Acidity", Journal of the American Chemical Society, 123, 7949-7950 (2001).

(81) Y. Chiang, A. G. Griesbeck, H. Heckroth, B. Hellrung, A. J. Kresge, Q. Meng, A. C. O'Donoghue, J. P. Richard and J. Wirz, "Keto-Enol/Enolate Equilibria in the N‑Acetylamino-p-methylacetophhenone System. Effect of a b-Nitrogen Substituent", Journal of the American Chemical Society, 123, 8979-8984 (2001).

(82) T. L. Amyes, A. C. O'Donoghue and J. P. Richard, "Contribution of Phosphate Intrinsic Binding Energy to the Enzymatic Rate Acceleration for Triosephosphate Isomerase", Journal of the American Chemical Society, 123, 11325-11326 (2001).

(83) J. P. Richard, G. Williams, A. C. O'Donoghue and T. L. Amyes, "Formation and Stability of Enolates of Acetamide and Acetate Anion: An Eigen Plot for Proton Transfer at a‑Carbonyl Carbon", Journal of the American Chemical Society, 124, 2957-2968, (2002).

(84) A. Rios, J. P. Richard and T. L. Amyes, "Formation and Stability of Peptide Enolates in Aqueous Solution", Journal of the American Chemical Society, 124, 8251-8259, (2002).

(85) M. M. Toteva and J. P. Richard, "Hydrogen Bonding and Catalysis of Solvolysis of 4‑Methoxybenzyl Fluoride", Journal of the American Chemical Society, 124, 9798-9805 (2002).

(86) Y. Chiang, H.-X. Guo, A. J. Kresge, J. P. Richard, and K. Toth, "The Mandelamide Keto-Enol System in Aqueous Solution. Generation of the Enol by Hydration of Phenylcarbamoylcarbene", Journal of the American Chemical Society, 125, 187-194 (2003)

(87) O. Iranzo, A. Y. Kovalevsky, J. R. Morrow and J. P. Richard, "Physical and Kinetic Analysis of the Cooperative Role of Metal Ions in Catalysis of Phosphodiester Cleavage by a Dinuclear Zn(II) Complex", Journal of the American Chemical Society, 125, 1988-1993 (2003).

(88) G. Williams, P. Maziarz  III, Tina L. Amyes, Troy D. Wood  and John P. Richard "Formation and Stability of the Enolates of N-Protonated Proline Methyl Ester and Proline Zwitterion in Aqueous Solution: A Nonenzymatic Model for the First Step in the Racemization of Proline Catalyzed by Proline Racemase", Biochemistry, 42, 8354-8361 (2003).

(89) M. M. Toteva, M. Moran, T. L. Amyes and J. P. Richard, "Substituent Effects on Carbocation Stability: The pK_R for p-Quinone Methide", Journal of the American Chemical Society, 125, 8814-8819 (2003).

(90) Y. Tsuji, T. Mori, M. M. Toteva and J. P. Richard, "Dynamics for Reaction of Ion Pairs in Aqueous Solution: Racemization of the Chiral Ion Pair Intermediate of Solvolysis of (S) 1-(4-Methylphenyl)ethyl Pentafluorobenzoate",  Journal of Physical Organic Chemistry, [Special Issue dedicated to Shinjiro Kobayashi] 16, 484-490 (2003).

(91) M.-Y. Yang, J. P. Richard and Janet R. Morrow "Substrate Specificity for Catalysis of Phosphodiester Cleavage by a Dinuclear Zn(II) Complex", Journal of the Chemical Society, Chemical Communications, 2832-2833 (2003).

(92) O. Iranzo, T. Elmer, J. P. Richard and J. R. Morrow "Cooperativity between Metal Ions in the Cleavage of  Phosphate Diesters and RNA by Dinuclear Zn(II) Catalysts" [Cover Article], Inorganic Chemistry, 42, 7737-7746 (2003).

(93) Y. Tsuji, M. M. Toteva and J. P. Richard, "Ambident Nucleophilic Reactivity of Phenol/Phenoxide Ion: Kinetics and Thermodynamics of C- and O-Alkylation of a Benzylic Carbocation", Journal of the American Chemical Society, 125, 15455-15466 (2003)

(94) O. Iranzo, J. P. Richard and J. R. Morrow.  "Structure Activity Studies of Transesterification of an RNA Analog Catalyzed  by a Potent Dinuclear Metal Ion Complex: The Effect of Changing Metal Cation." Inorganic Chemistry. 43,1743-1750 (2004).

(95) J. P. Richard, J. R. Morrow, A. C. O'Donoghue and Y. Y. Pyun, "Kinetic Studies of RNA Cleavage by Lanthanide Macrocyclic Complexes, Bulletin Korean Chemical Society, 25, 403-406, (2004).

(96) T. L. Amyes, S. T. Diver, J. P. Richard, F. M. Rivas and K. Toth, "Formation and Stability of N-Heterocyclic Carbenes in Water: The Carbon Acid pKa of Imidazolium Cations in Aqueous Solution", Journal of the American Chemical Society, 126, 4366-4374 (2004).

(97) J. Crugeiras and J. P. Richard, "A Comparison of the Electrophilic Reactivities of Zn2+ and Acetic Acid as Catalysts of Enolization: Imperatives for Enzymatic Catalysis of Proton Transfer at Carbon", Journal of the American Chemical Society, 126, 5164-5173 (2004).

(98) K. Toth, T. L. Amyes, J. P. Richard, J. P. G. Malthouse and M. E. NíBeilliú, "Claisen-Type Addition of Glycine to Pyridoxal in Water", Journal of the American Chemical Society, 126, 10538-10539 (2004).

(99) Yutaka Tsuji, Maria M. Toteva, Tina L. Amyes, and John P. Richard, "Scrambling of Oxygen-18 During the "Borderline" Solvolysis of 1-(3-Nitrophenyl)ethyl Tosylate", Organic Letters, 6, 3633-3636 (2004).

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