Randall D. Shortridge, Ph.D.


1996-present,  Associate Professor, SUNY-Buffalo.

 1990-1996,  Assistant Professor, SUNY-Buffalo.

1986-1990, Postdoctoral Research Associate, Purdue University.

1982-1986, Graduate Research Assistant, North Texas State University (Ph.D. in Biochemistry,1986). 


Research Projects: 



        Shortridge, R. D., Pirtle, I. L. and Pirtle, R. M. (1985) Nucleotide sequence and transcription of a gene encoding human tRNAGlyCCC. Gene, 33, 269-277.  

        Shortridge, R. D., Pirtle, I. L. and Pirtle, R. M. (1986) IBM microcomputer programs that analyse DNA sequences for tRNA genes. Computer Applications in the Biosciences, 2, 13-17.             

        Pirtle, I. L., Shortridge, R. D. and Pirtle, R. M. (1986) Nucleotide sequences and transcription of a human glycine tRNAGCC gene and nearby pseudogene. Gene, 43, 155-167.

        Bloomquist, B. T., Shortridge, R. D., Schneuwly, S., Perdew, M., Montell, C., Steller, H., Rubin, G., and Pak., W. L. (1988) Isolation of a putative phospholipase C gene of Drosophila, norpA, and its role in phototransduction. Cell, 54, 723-733.

        Shortridge, R. D., Bloomquist, B. T., Schneuwly, S., and Pak, W. L. (1988) norpA, putative phospholipase C gene expressed in the eye of Drosophila.  In Proc. XXI Yamada Conference on Molecular Physiology of Retinal Proteins, T. Hara, T. Yoshizawa, and K. Ozaki (eds.), Yamada Science Foundation, pp 195-202.

        Bloomquist, B. T., Shortridge, R. D., Montell, C., Steller, H., Rubin, G., and Pak, W. L. (1988) Isolation of a gene associated with eye-specific phospholipase C activity in Drosophila. In Molecular Biology of the Eye: Genes, Vision, and Ocular Disease, J. Piatigorsky, P. Zelenka, and T. Shinohara (eds.), UCLA Symp. Mol. Cell. Biol., Vol. 88, Alan R. Liss, Inc., N.Y., pp 117-123.

        Shortridge, R. D., Johnson, G. D., Craig, L. C., Pirtle, I. L. and Pirtle, R. M. (1989) A human tRNA gene heterocluster encoding threonine, proline, and valine tRNAs. Gene, 79, 309-324.

        Yoon, J., Shortridge, R. D., Bloomquist, B. T., Schneuwly, S., Perdew, M. and Pak, W. L. (1989) Molecular characterization of a Drosophila gene encoding a Go alpha subunit homolog. J. Biol. Chem., 264, 18536-18543.

        Schneuwly, S., Shortridge, R. D., Larrivee, D. L., and Pak, W. L. (1989) Drosophila ninaA gene encodes an eye-specific cyclophilin (cyclosporine A binding protein). Proc. Natl. Acad. Sci., USA, 86, 5390-5394.

        Shortridge, R. D., Yoon, J. Y., Lending, C., Bloomquist, B. T., Perdew, M., and Pak, W. L. (1991) A Drosophila phospholipase C gene that is expressed in the central nervous  system. J. Biol. Chem., 266, 12474-12480.

        Pak, W. L. and Shortridge, R. D.  (1991) Inositol phospholipid and invertebrate photoreceptors. Photochem. and Photobiol., 53, 871-875.

        Ferreira, P.A., Shortridge, R.D., and Pak, W.L.  (1993)  Distinctive subtypes of  bovine phospholipase C that have preferential expression in the retina and high homology to the norpA gene product of Drosophila.  Proc. Natl. Acad. Sci., USA, 90, 6042-6046.

        Zhu, L., McKay, R.R., and Shortridge, R.D.  (1993)  Tissue-specific expression of phospholipase C encoded by the norpA gene of  Drosophila melanogaster.  J. Biol. Chem., 268, 15994-16001.

        McKay, R.R., Miller, K., Weckstrom, M., Torkkeli, P., Jarvilehto, M. and Shortridge, R.D. (1994)  The rpa (receptor potential absent) visual mutant of the blowfly (Calliphora erythrocephala) is deficient in phospholipase C in the eye.  J. Neurogenetics, 9, 177-187.

        McKay, R.R., Zhu, L., and Shortridge, R.D.  (1994)  Membrane association of phospholipase C encoded by the norpA gene of  Drosophila melanogaster.  Neuroscience, 61, 141-148.

        McKay, R.R., Zhu, L., and Shortridge, R.D.  (1995)  A Drosophila gene that encodes a member of the protein disulfide isomerase/phospholipase C-a family.  Insect Biochemistry and Molecular Biology, 25, 647-654.

        McKay, R.R., Chen, D.-M., Miller, K., Kim, S., Stark, W.S. and Shortridge, R.D.  (1995) Phospholipase C rescues visual defect of norpA mutant of Drosophila melanogaster,  J. Biol. Chem., 270, 13271-13276.  http://www.jbc.org/cgi/content/full/270/22/13271

        Kim, S., McKay, R.R., Miller, K., and Shortridge, R.D.  (1995)  Multiple subtypes of phospholipase C are encoded by the norpA gene of Drosophila melanogaster, J. Biol. Chem., 270, 14376-14382.  http://www.jbc.org/cgi/content/full/270/24/14376

        Shortridge, R.D. and McKay, R.R.  (1995)  Invertebrate phosphatidylinositol-specific phospholipases C and their role in cell signaling, Invertebrate Neuroscience, 1, 199-206.

        Pearn, M.T., Randall, L.L., Shortridge, R.D. and Pak, W.L. (1996)  Molecular, biochemical, and electrophysiological characterization of Drosophila norpA mutants, J. Biol. Chem., 271, 4937-4945. http://www.jbc.org/cgi/content/full/271/9/4937

        Van Huizen, R., Miller, K., Chen, D.-M.,  Li, Y.,  Lai, Z.-C.,  Raab, R.W.,  Stark, W.S., Shortridge, R.D.  and Li, M.   (1998)  Two distantly positioned PDZ domains mediate multivalent INAD-phospholipase C interactions essential for G protein-coupled signaling.  EMBO Journal, 17, 2285-2297.   http://www.emboj.org/cgi/content/full/17/8/2285

        Kim, G., Shortridge, R.D., Seong, C., Oh, Y., Baek, K. and Yoon J.  (1998)  Molecular characterization of a novel Drosophila gene which is expressed in the central nervous system.  Molecules & Cells, 8, 750-757. 

       Shim, K, Zavarella, K.M., Thomas, C.F., Shortridge, R.D. and Stark, W.S.   (2001)   Evidence for indirect control of phospholipase C (PLC-b) by retinoids in Drosophila phototransduction, Molecular Vision, 7, 216-221.   http://www.molvis.org/molvis/v7/a30/
        Kim, S., Chen D-M, Zavarella, K., Fourtner, C.F., Stark, W.S. and Shortridge, R.D.  (2003)  Substitution of a non-retinal phospholipase C in Drosophila phototransduction.  Insect Mol. Biol., 12, 147-153. 

        Liu, W., Gnanasambandam, R., Benjamin, J., Kaur, G., Getman, P.B., Siegel, A.J., Shortridge, R.D. and Singh, S. (2007) Mutations in cytochrome c oxidase subunit Via cause neurodegeneration and motor dysfunction in Drosophila.  Genetics, 176, 937-946.   http://www.genetics.org/cgi/content/full/176/2/937

       Shortridge, R.D.  (2012) Impact of studies of the Drosophila norpA mutation on understanding phototransduction,   J Neurogenetics, 26, 123-131.  http://informahealthcare.com/doi/full/10.3109/01677063.2011.647142


Personal and Misc:

Contact Information:

State University of New York

Department of Biological Sciences

Cooke Hall, Room 109

Buffalo, NY 14260-1300

Phone:  716-645-4920

FAX:  716-645-2975



Cooke Hall


Cooke Hall is located on the west end of the North (Amherst) SUNY-Buffalo campus.  For more detailed maps and other information, visit the main SUNY-Buffalo website.



State University of New York-Buffalo (UB) website.

UB Wings website

UB College of Arts and Sciences 

UB Department of Biological Sciences

Last site update:  10/16/2012