Bo An

Introduction

I obtained my bachelor's degree in Pharmaceutics at China Pharmaceutical University in 2009. With a couple of years of industry experiences in drug developments, I joined the Pharmaceutical Sciences Department, University at Buffalo, in 2012. I will receive my MS degree in Pharmaceutical Sciences in September 2014, and I am going to continue my PhD degree in Pharmaceutical Sciences at Buffalo. My research interests are LC/MS based biotherapeutics development approaches, including analysis method development, optimization, application on mAb quantification in biomatrix and ADC characterization, and biotherapeutics PK/PD study.  

Publications

1. An B, Zhang M, Johnson RW, Qu J*. Surfactant-Aided Precipitation/On-Pellet-Digestion (SOD) Procedure Provides Robust and Rapid Sample Preparation for Reproducible, Accurate and Sensitive LC-MS Quantification of Therapeutic Protein in Plasma and Tissues. Anal Chem. 87(7):4023-9 (2015)

2. Nouri-Nigjeh E, Zhang M, Ji T, Yu H, An B, Duan X, Balthasar J, Johnson RW, Qu J*. Effects of calibration approaches on the accuracy for LC-MS targeted quantification of therapeutic protein. Anal Chem. 86(7):3575-84. (2014)

3. An B, Zhang M, Qu J*. Towards Sensitive and Accurate Analysis of Antibody Biotherapeutics by LC/MS. Drug Metab. Dispos. 42(11):1858-66 (2014)

4. Qu M, An B, Shen S, Zhang M, Shen X, Duan X, Balthasar JP, Qu J*. Qualitative and quantitative characterization of protein therapeutics with liquid chromatography and mass spectrometry. Mass Spectrom Rev. [Epub ahead of print]. (2016)

5. Tu C, Mojica W, Straubinger RM, Li J, Shen S, Qu M, Nie L, Roberts R, An B, Qu J*. Quantitative proteomic profiling of paired cancerous and normal colon epithelial cells isolated freshly from colorectal cancer patients. Proteomics Clin Appl. 11(5-6). (2017)

6. Fu W, An B, Wang X, Qu J*. Key considerations for LC-MS analysis of protein biotherapeutics in tissues. Bioanalysis. 9(18):1349-1352. (2017)

7. Zhang M, An B, Qu Y, Shen S, Fu W, Chen YJ, Wang X, Young R, Canty JM Jr., Balthasar JR, Murphy K, Bhattacharyya D, Josephs J, Ferrari L, Zhou S, Bansal S, Vazvaei F*, Qu J*. Sensitive, High-Throughput, and Robust Trapping-Micro-LC-MS Strategy for the Quantification of Biomarkers and Antibody Biotherapeutics. Anal Chem. 90(3):1870-1880. (2018)

8. Engler FA, Polli JR, Li TR, An B, Otteneder MB, Qu J, Balthasar JP*. "Catch-and-Release" anti-CEA mAb leads to greater plasma and tumor exposure in a mouse model of colorectal cancer. J Pharmacol Exp Ther. [Epub ahead of print]. (2018)

Update date: May, 2018