Jun Li, Ph.D

Introduction

I got my Ph.D in Analytical Chemistry at the Institute of Chemistry, CAS in 2007, and my research interests focused on the enhancing of peptide signal response in MALDI-Tof-MS by derivatization with various derivatives.
In March 2009, I came to US. My research interest is the proteomic investigation by using various analytical technologies, currently focused on the proteomic-scale identification and quantification of effector proteins/biomarkers in highly complex biological samples.

Selected Publications

1. Tu C, Sheng Q, Li J, Ma D, Shen X, Wang X, Shyr Y, Yi Z, Qu J*. Optimization of Search Engines and Postprocessing Approaches to Maximize Peptide and Protein Identification for High-Resolution Mass Data. J Proteome Res. In press (2015)

2. Shen X, Hu Q, Li J, Wang J, Qu J*. Experimental Null Method to Guide the Development of Technical Procedures and to Control False-Positive Discovery in Quantitative Proteomics. J Proteome Res. 14(10):4147-57 (2015)

3. Lott K, Mukhopadhyay S, Li J, Wang J, Yao J, Sun Y, Qu J, Read LK. Arginine methylation of DRBD18 differentially impacts its opposing effects on the trypanosome transcriptome. Nucleic Acids Res. pii: gkv428. (2015)

4. Zhang T, Price JC, Nouri-Nigjeh E, Li J, Hellerstain MK, Qu J, Ghaemmaghami S. Kinetics of precursor labeling in stable isotope labeling in cell cultures (SILAC) experiments. Anal Chem. 86(22):11334-41 (2014)

5.Nouri-Nigjeh E, Sukumaran S, Tu C, Li J, Shen X, Duan X, DuBois DC, Almon RR, Jusko WJ, Qu J*. Highly Multiplexed and Reproducible Ion Current-Based Strategy for Large-Scale Quantitative Proteomics and the Application to Protein Expression Dynamics Induced by Methylprednisolone in 60 Rats. Anal Chem. 86(16):8149-57 (2014)

6. Qu J*, Young R, Page BJ, Shen X, Tata N, Li J, Duan X, Fallavollita JA, Canty JM Jr. Reproducible Ion-Current-Based Approach for 24-Plex Comparison of the Tissue Proteomes of Hibernating versus Normal Myocardium in Swine Models. J Proteome Res. 2014 Apr 4. J Proteome Res. 13(5):2571-84 (2014)

7. Tu C, Sheng Q, Li J, Shen X, Zhang M, Shyr Y, Qu J*. ICan: An Optimized Ion Current-Based Quantification Procedure with Enhanced Quantitative Accuracy and Sensitivity in Biomarker Discovery. J Proteome Res.13(12):5888-97 (2014)

8. Tu C, Li J, Sheng Q, Zhang M,Qu J*. Systematic assessment of survey scan and MS2-based abundance strategies for label-free quantitative proteomics using high-resolution MS data. J Proteome Res.13(4):2069-79. (2014)

9. Tu C, Mammen MJ, Li J, Shen X, Jiang X, Hu Q, Wang J, Sethi S, Qu J*. Large-scale, ion-current-based proteomics investigation of bronchoalveolar lavage fluid in chronic obstructive pulmonary disease patients. J Proteome Res. 13(2):627-39. (2014)

10. Tu C, Li J, Jiang X, Sheflin LG, Pfeffer BA, Behringer M, Fliesler SJ, Qu J*. Ion-current-based proteomic profiling of the retina in a rat model of Smith-Lemli-Opitz syndrome. Mol Cell Proteomics. 12(12):3583-98 (2013)

11. Lott K, Li J, Fisk JC, Wang H, Aletta JM, Qu J*, Read LK. Global proteomic analysis in trypanosomes reveals unique proteins and conserved cellular processes impacted by arginine methylation. J Proteomics.91:210-25. (2013)

12. Fisk JC, Li J, Wang H, Aletta JM, Qu J*, and Read LK. Proteomic analysis reveals diverse classes of arginine methylproteins in mitochondria of trypanosomes. Mol. Cell. Proteomics. 12(2):302-11 (2013)

Update date: Sep, 2016