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Recent Publications

Functional Mapping
Polyploid Mapping
Linkage Disequilibrium Mapping
Mapping in Outcrossing Species
Seed Development Mapping
Sequencing Complex Traits with HapMap
Molecular Map Construction



Functional Mapping

Ma, C.-X., R. L. Wu and G. Casella, 2004 FunMap: Functional mapping of complex traits. Bioinformatics 20: 1808-1811.

Ma, C.-X., M. Lin, G. Casella, R. C. Littell, T. M. Yin and R. L. Wu, 2004 A statistical model for mapping growth trajectories using dominant markers. Theoretical and Applied Genetics 108: 699-705.

Zhao, W., C.-X. Ma, J. M. Cheverud and R. L. Wu, 2004 A unifying statistical model for QTL mapping of genotype-sex interaction for developmental trajectories. Physiological Genomics 19: 218-227.

Zhao, W., R. L. Wu, C.-X. Ma and G. Casella, 2004 A fast algorithm for functional mapping of complex traits. Genetics 167: 2133-2137.

Zhao, W., J. Zhu, M. Gallo-Meagher and R. L. Wu, 2004 A unified statistical model for functional mapping of genotype-environment interactions for ontogenetic development. Genetics 169: 000-000.

Liu, T., W. Zhao, L. L. Tian and R. L. Wu, 2004 An algorithm for molecular dissection of tumor progression. Journal of Mathematical Biology (in press).

Wu, R. L., Z. H. Wang, W. Zhao and J. M. Cheverud, 2004 A mechanistic model for genetic machinery of ontogenetic growth. Genetics (in press).

Lin, M., W. Zhao and R. L. Wu, 2004 A genetic model for power curves in bird flight. Mathematical Medicine and Biology (accepted).

Wang, Z. H., and R. L. Wu, 2004 A statistical model for high-resolution mapping of quantitative trait loci determining human HIV-1 dynamics. Statistics in Medicine 23: 3033-3051.

Gong, Y., Z. H. Wang, T. Liu, W. Zhao, Y. Zhu and R. L. Wu, 2004 A statistical model for high-resolution mapping of quantitative trait loci affecting pharmacodynamic processes. The Pharmacogenomics Journal 4: 315-321.


Wu, R. L., C.-X. Ma, M. Lin, Z. H. Wang and G. Casella, 2004 Functional mapping of growth QTL using a transform-both-sides logistic model. Biometrics 60: 729-738.

Wu, R. L., C.-X. Ma, M. Lin and G. Casella, 2004 A general framework for analyzing the genetic architecture of developmental characteristics. Genetics 166: 1541-1551.

Wu, R. L., C.-X. Ma, Y.-X. Lou and G. Casella, 2003 Molecular dissection of allometry, ontogeny and plasticity: A genomic view of developmental biology. BioScience 53: 1041-1047.

Ma, C. X., G. Casella, R. C. Littell, K. A. I. Khuri and R. L. Wu, 2003 Exponential mapping of quantitative traits governing allometric relationships in organisms. Journal of Mathematical Biology 47: 313-324.

Wu, R. L., C.-X. Ma, W. Zhao and G. Casella, 2003 Functional mapping of quantitative trait loci underlying growth rates: A parametric model. Physiological Genomics 14: 241-249.


Wu, R. L., C. X. Ma, M. C. K. Yang, M. Chang, U. Santra, S. S. Wu, M. Huang, M. Wang and G. Casella, 2003 Quantitative trait loci for growth in Populus. Genetical Research 81: 51-64.  [Abstract]  [Full Text]

Wu, R. L., C. X. Ma, M. Chang, R. C. Littell, S. S. Wu, M. Huang, M. Wang and G. Casella, 2002 A logistic mixture model for detecting major genes governing growth trajectories. Genetical Research 79:235-245.  [Abstract]  [Full Text]

Wu, R. L., C. X. Ma, R. C. Littell and G. Casella, 2002 A statistical model for the genetic origin of allometric scaling laws in biology. Journal of Theoretical Biology 217: 275-287.  [Abstract]  [Full Text]

Ma, C. X., G. Casella, and R. L. Wu, 2002 Functional mapping of quantitative trait loci underlying the character process: A theoretical framework. Genetics 161: 1751-1762.  [Abstract]  [Full Text]

Wu, R. L., C.-X. Ma, J. Zhu and G. Casella, 2002 Mapping epigenetic quantitative trait loci (QTL) altering a developmental trajectory. Genome 45: 28-33.  [Abstract]  [Full Text]


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Polyploid Mapping

Wu, R. L., C.-X. Ma and G. Casella, 2004 A bivalent polyploid model for mapping quantitative trait loci in outcrossing tetraploids. Genetics 166: 581-595.

Wu, R. L., C. X. Ma and G. Casella, 2004 A mixed polyploid model for linkage analysis in tetraploids. Journal of Computational Biology 11: 562-580.

Wu, R. L., C.-X. Ma and G. Casella, 2002 A bivalent polyploid model for linkage analysis in outcrossing tetraploid species. Theoretical Population Biology 62: 129151.  
[Abstract]  [Full Text]

Ma, C.-X., G. Casella, T. C. Osborn and R. L. Wu, 2002 A unified framework for mapping quantitative trait loci in bivalent tetraploids using single-dose restriction fragments: A case study from alfalfa. Genome Research 12: 1974-1981.  [Abstract]  [Full Text]

Wu, S. S., R. L. Wu, C. X. Ma, Z.-B. Zeng, M. Yang and G. Casella, 2001 A multivalent pairing model of linkage analysis in autotetraploids. Genetics 159: 1339-1350 (the first two authors contribute equally to this work).  [Abstract]  [Full Text]

Wu, R. L., M. Gallo-Meagher, R. C. Littell and Z.-B. Zeng, 2001 A general polyploid model for analyzing gene segregation in outcrossing autotetraploid species. Genetics 159: 869-882.  [Abstract]  [Full Text]


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Linkage Disequilibrium Mapping

Lou, X.-Y., G. Casella, R. J. Todhunter, M. C. K. Yang and R. L. Wu, 2004 A general statistical framework for unifying interval and linkage disequilibrium mapping: Towards high-resolution mapping of quantitative traits. Journal of American Statistical Association 99: 000-000.

Lou, X.-Y., R. J. Todhunter, M. Lin, Q. Lu, T. Liu, Z. H. Wang, S. Bliss, G. Casella, A. C. Acland, G. Lust and R. L. Wu, 2003 The extent and distribution of linkage disequilibrium in canine. Mammalian Genome 14: 555-564.


Lou, X.-Y., G. Casella, R. C. Littell, M. K. C. Yang and R. L. Wu, 2003 A haplotype-based algorithm for multilocus linkage disequilibrium mapping of quantitative trait loci with epistasis in natural populations. Genetics 163: 1533-1548.  
[Abstract]  [Full Text]

Wu, R. L., C.-X. Ma and G. Casella, 2002 Joint linkage and linkage disequilibrium mapping of quantitative trait loci in natural populations. Genetics 160: 779-792.  [Abstract]  [Full Text]

Wu, R. L.,  and Z-B. Zeng, 2001 Joint linkage and linkage disequilibrium mapping in natural populations. Genetics 157: 899-909.  [Abstract]  [Full Text]


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Mapping in Outcrossing Species

Lu, Q., Y. H. Cui and R. L. Wu, 2004 A multilocus likelihood approach to joint modeling of linkage, parental diplotype and gene order in a full-sib family. BMC Genetics 5: 20 (http://www.biomedcentral.com/content/pdf/1471-2156-5-20.pdf).

Lin, M., X.-Y. Lou, M. Chang and R. L. Wu, 2003 A general statistical framework for mapping quantitative trait loci in non-model systems: Issue for characterizing linkage phases. Genetics 165: 901-913.

Wu, R. L., C. X. Ma, S. S. Wu and Z-B. Zeng, 2002 Linkage mapping of sex-specific differences. Genetical Research 79: 85-96.  [Abstract]  [Full Text]

Wu, R. L., C.-X. Ma, I. Painter and Z.-B. Zeng, 2002 Simultaneous maximum likelihood estimation of linkage and linkage phases in outcrossing species. Theoretical Population Biology 61: 349-363.  [Abstract]  [Full Text]


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Seed Development Mapping

Cui, Y. H., G. Casella and R. L. Wu, 2004 Mapping quantitative trait locus interactions from the maternal and offspring genomes. Genetics 167: 1017-1026.

Wu, R. L., X.-Y. Lou, C.-X. Ma, X. L. Wang, B. A. Larkins and G. Casella, 2002 An improved genetic model generates high-resolution mapping of QTL for protein quality in maize endosperm. Proceedings of the National Academy of Sciences of the United States of America 99: 1128111286.  [Abstract]  [Full Text]

Wu, R. L., C.-X. Ma, M. Gallo-Meagher, R. C. Littell and G. Casella, 2002 Statistical methods for dissecting triploid endosperm traits using molecular markers: An autogamous model. Genetics 162: 875-892.  [Abstract]  [Full Text]


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Sequencing Complex Traits with HapMap

Liu, T., J. A. Johnson, G. Casella and R. L. Wu, 2004 Sequencing complex diseases with HapMap. Genetics 168: 000-000.


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Molecular Map Construction

Zhang, B., T. M. Yin, Q. Zhuge, Z. M. Han, M. X. Wang, R. L. Wu and M. R. Huang, 2002 Detection of genes affecting fusiform diseases in poplars using molecular markers. Hereditas (Beijing) 23: 400-404.

Yin, T. M., X. Y. Zhang, M. R. Huang, M. X. Wang, Q. Zhuge, S. M. Tu, L.-H. Zhu and R. L. Wu, 2002 The molecular linkage maps of the Populus genome. Genome 45: 541-555.  
[Abstract]  [Full Text]

Yin, T. M., M. R. Huang, M. X. Wang, Z.-B. Zeng and R. L. Wu, 2001 Interspecific linkage maps of Populus adenopoda P. alba. Genome 44: 602-609.  [Abstract]  [Full Text]

Zhang, X. Y., D. M. Yin, Q. Zhuge, M. R. Huang, L. H. Zhu, W. X. Zhai, R. L. Wu and M. X. Wang, 2000 RAPD linkage mapping in a P. deltoides P. euramericana F1 family. Hereditas (Beijing) 22: 209-213.

Wu, R. L., Y. F. Han, J. J. Hu, L. Li, M. L. Li and Z-B. Zeng, 2000 An integrated genetic map of Populus based on amplified fragment length polymorphisms. Theoretical and Applied Genetics 100: 1249-1256.


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Last update made Jan 2, 2005.