Selected Publications

  • # These authors contribute equally.
  • * Corresponding author.

  • Min Ma#, Shihan Huo#, Ming Zhang, Shuo Qian, Xiaoyu Zhu, Jie Pu, Sailee Rasam, Chao Xue, Shichen Shen, Bo An, Jianmin Wang and Jun Qu*. In-depth Mapping of Protein Localizations in Whole Tissue by Micro-scaffold Assisted Spatial Proteomics (MASP). Nat. Commun. 2022. Dec 14;13(1):7736. View full article.

  • Shichen Shen#, Xue Wang#, Xiaoyu Zhu, Sailee Rasam, Min Ma, Shihan Huo, Shuo Qian, Ming Zhang, Miao Qu, Chenqi Hu, Liang Jin, Yu Tian, Sanjay Sethi, David Poulsen, Jianmin Wang, Chengjian Tu, and Jun Qu*. High-quality and robust protein quantification in large clinical/pharmaceutical cohorts with IonStar proteomics investigation. Nat. Prot. 2022. Dec 9. View full article

  • Xue Wang, Liang Jin, Chenqi Hu, Shichen Shen, Shuo Qian, Min Ma, Xiaoyu Zhu, Fengzhi Li, Jianmin Wang, Yu Tian*, and Jun Qu*. Ultra-High-Resolution IonStar Strategy Enhancing Accuracy and Precision of MS1-Based Proteomics and an Extensive Comparison with State-of-the-Art SWATH-MS in Large-Cohort Quantification. Anal. Chem. 2021 Mar 23;93(11):4884-4893. View full article

  • Shichen Shen, Jun Li, Shihan Huo, Min Ma, Xiaoyu Zhu, Sailee Rasam, Xiaotao Duan*, Miao Qu*, Mark A. Titus*, and Jun Qu*. Parallel, High-Quality Proteomic and Targeted Metabolomic Quantification Using Laser Capture Microdissected Tissues. Anal. Chem. 2021 Jun 29;93(25):8711-8718. View full article

  • Bo An, Ming Zhang, Jie Pu, Yang Qu, Shichen Shen, Shaolian Zhou, Luca Ferrari, Faye Vazvaei, and Jun Qu*. Toward Accurate and Robust Liquid Chromatography-Mass Spectrometry-Based Quantification of Antibody Biotherapeutics in Tissues. Anal. Chem. 2020 Nov 17;92(22):15152-15161. View full article

  • Xue Wang, Shichen Shen, Sailee Suryakant Rasam, and Jun Qu*. MS1 ion current-based quantitative proteomics: A promising solution for reliable analysis of large biological cohorts. Mass Spectrom. Rev. 2019 Nov;38(6):461-482. View full article.

  • Bo An, Ming Zhang, Jie Pu, Shichen Shen, Yang Qu, Yuan-Ju Chen, Shihan Huo, Xue Wang, Joseph Ryan Polli, Joseph P. Balthasar, Denis Herzog, Luca Ferrari, Roland F. Staack, Wolfgang F. Richter, Michael B. Otteneder, Lisa J. Benincosa, Shaolian Zhou, Faye Vazvaei*, and Jun Qu*. High-throughput, sensitive LC-MS quantification of biotherapeutics and biomarkers using an antibody-free, peptide-level multiple-mechanism enrichment via strategically regulated pH, ionic and solvent strengths. Anal. Chem. 2019 Mar 5;91(5):3475-3483. View full article.

  • Xue Wang, Jin Niu, Jun Li, Xiaomeng Shen, Shichen Shen, Robert M. Straubinger*, and Jun Qu*. Temporal Effects of Combined Birinapant and Paclitaxel on Pancreatic Cancer Cells Investigated via Large-scale, Ion-Current-Based Quantitative Proteomics (IonStar). Mol. Cell. Proteomics. 2018 Apr;17(4):655-671. View full article.

  • Ming Zhang, Bo An, Yang Qu, Shichen Shen, Wei Fu, Yuan-Ju Chen, Xue Wang, Rebeccah Young, John M. Canty, Jr., Joseph P. Balthasar, Keeley Murphy, Debadeep Bhattacharyya, Jonathan Josephs, Luca Ferrari, Shaolian Zhou, Surendra Bansal, Faye Vazvaei*, and Jun Qu*. Sensitive, High-Throughput, and Robust Trapping-Micro-LC-MS Strategy for the Quantification of Biomarkers and Antibody Biotherapeutics. Anal. Chem. 2018 Feb 6;90(3):1870-1880. View full article

  • Xiaomeng Shen#, Shichen Shen#, Jun Li, Qiang Hu, Lei Nie, Chengjian Tu, Xue Wang, David J. Poulsen, Benjamin C. Orsburn*, Jianmin Wang*, and Jun Qu*. IonStar enables high-precision, low-missing-data proteomics quantification in large biological cohorts. Proc. Natl. Acad. Sci. U S A. 2018 May 22;115(21):E4767-E4776. View full article.

  • Shichen Shen, Bo An, Xue Wang, Shannon P. Hilchey, Jun Li, Jin Cao, Yu Tian, Chenqi Hu, Liang Jin, Andrew Ng, Chengjian Tu, Miao Qu*, Martin S. Zand*, and Jun Qu*. Surfactant Cocktail-Aided Extraction/Precipitation/On-Pellet Digestion Strategy Enables Efficient and Reproducible Sample Preparation for Large-Scale Quantitative Proteomics. Anal. Chem. 2018 ep 4;90(17):10350-10359. View full article.

  • Xiaomeng Shen, Shichen Shen, Jun Li, Qiang Hu, Lei Nie, Chengjian Tu, Xue Wang, Benjamin Orsburn*, Jianmin Wang*, and Jun Qu*. An IonStar Experimental Strategy for MS1 Ion Current-Based Quantification Using Ultrahigh-Field Orbitrap: Reproducible, In-Depth, and Accurate Protein Measurement in Large Cohorts. J. Proteome Res. 2017 Jul 7;16(7):2445-2456. View full article.

  • Chengjian Tu*, Wilfrido Mojica, Robert M. Straubinger, Jun Li, Shichen Shen, Miao Qu, Lei Nie, Rick Roberts, Bo An, Jun Qu*. Quantitative proteomic profiling of paired cancerous and normal colon epithelial cells isolated freshly from colorectal cancer patients. Proteomics Clin. Appl. 2017 May;11(5-6):10.1002/prca.201600155. View full article.

  • Bo An, Ming Zhang, Robert W. Johnson*, and Jun Qu*. Surfactant-aided precipitation/on-pellet-digestion (SOD) procedure provides robust and rapid sample preparation for reproducible, accurate and sensitive LC/MS quantification of therapeutic protein in plasma and tissues. Anal. Chem. 2015 2015 Apr 7;87(7):4023-9. View full article.

  • Eslam Nouri-Nigjeh, Ming Zhang, Tao Ji, Haoying Yu, Bo An, Xiaotao Duan, Joseph Balthasar, Robert W. Johnson*, and Jun Qu*. Effects of calibration approaches on the accuracy for LC-MS targeted quantification of therapeutic protein. Anal. Chem. 2014 Apr 1;86(7):3575-84. View full article.

  • Chengjian Tu, Jun Li, Xiaosheng Jiang, Lowell G. Sheflin, Bruce A. Pfeffer, Matthew Behringer, Steven J. Fliesler*, Jun Qu*. Ion Current-Based Proteomic Profiling of the Retina in a Rat Model of Smith-Lemli-Opitz Syndrome. Mol. Cell. Proteomics. 2013 Dec;12(12):3583-98. View full article.

  • Jin Cao, Vanessa M. Covarrubias, Robert M. Straubinger, Hao Wang, Xiaotao Duan, Haoying Yu, Jun Qu*, and Javier G. Blanco. A rapid, reproducible, on-the-fly orthogonal array optimization method for targeted protein quantification by LC/MS and its application for accurate and sensitive quantification of carbonyl reductases in human liver. Anal. Chem. 2010 Sep 15;82(18):7861. View full article.

  • Xiaotao Duan, Rebeccah Young, Robert M. Straubinger, Brian Page, Jin Cao, Hao Wang, Haoying Yu, John M. Canty, Jr.*, and Jun Qu*. A straightforward and highly efficient precipitation/on-pellet digestion procedure coupled to a long gradient nano-LC separation and orbitrap mass spectrometry for label-free expression profiling of the swine heart mitochondrial proteome. J. Proteome Res. 2009 Jun;8(6):2838-50. View full article.

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Update date: January, 2023