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Min Ma
About Me
Home Town: Tianjin, China Undergraduate: Bachelor in Medicine, Preventive Medicine, Tianjin Medical University, China Graduate: PhD in Cancer Sciences, Roswell Park Comprehensive Cancer Center; MS in Nutrition Science, SUNY at Buffalo Skills: Liquid chromatograpy, Mass spectrometry, Quantitative proteomics, Spatial proteomics, Cancer research, Scientific figure design
Why Qu Lab?
Dr. Jun Qu’s lab is one of the best labs in the quantitative proteomic field. The lab has equipped with state-of-the-art LC-MS instruments. In Qu lab, we have a lot of opportunities of working with collaborators on a range of interesting research projects. During studies in our lab, we received systemic training as independent scientists. More importantly, the people in the lab are very supportive and proactive. I’m grateful to work in a lab like this.
What are you currently working on?
My current work focuses on the development of a novel Micro-scaffold Assisted Spatial Proteomics (MASP), capable of mapping >5000 proteins in the mouse brain, on the whole-tissue level. This technique has revealed the whole-tissue map of many proteins for the first time. The cerebral protein maps brought new insights into the spatially organized biological processes and signaling pathways, which are important for further understanding of neurodegenerative diseases (e.g., Alzheimer’s diseases, Parkinson’s diseases) and brain tumors. More importantly, the methods could not only study the intra-brain distribution of the mAb drug but also the related biomarkers with spatial resolution, and thus direct the pharmaceutical efforts in evaluating and designing more effective and safer biotherapeutics. The best part of this technique is its versatility. The MASP method has the potential to perform spatial proteoform studies, and multi-omics studies, and be applied in many tissue types and disease models. Now, we are conducting active studies of micro-scaffold-assisted spatial phosphoproteomics.
Figure: The workflow of the Micro-scaffold Assisted Spatial Proteomics (MASP).