Publications and Presentations

Select year range: 1978 - 1990 | 1991 - 1995 | 1996 - 1999 | 2000 - 2004

Links to the pdf-version of papers are provided for convenience only. Users must have Acrobat Reader and must have access to the journal sites. The following list of publications can also be downloaded as pdf-file.

:: Research Publications 1996 - 1999

(52) T. L. Amyes and J. P. Richard, "Determination of the pK_a of Ethyl Acetate: Broensted Correlation for Deprotonation of a Simple Oxygen Ester in Aqueous Solution", Journal of the American Chemical Society, 118, 3129-3141 (1996).

(53)R. W. Nagorski and J. P. Richard, "Mechanistic Imperatives for Enzymatic Catalysis of Aldose-Ketose Isomerization: Isomerization of Glyceraldehyde in Weakly Alkaline Aqueous Solution Occurs with Intramolecular Transfer of a Hydride Ion", Journal of the American Chemical Society, 118, 7432-7433 (1996).

(54) J. P. Richard, R. E. Huber, S. Lin, C. Heo and T. L. Amyes, "Structure-Reactivity Relationships for b-Galactosidase (Escherichia coli, lac Z). 3. Evidence that Glu-461 Participates in Broensted Acid-Base Catalysis of β-D-Galactopyranosyl Group Transfer", Biochemistry, 35, 12377-12386 (1996).

(55) J. P. Richard, R. E. Huber, C. Heo, T. L. Amyes and S. Lin, "Structure-Reactivity Relationships for b-Galactosidase (Escherichia coli, lac Z). 4. Mechanism for Reaction of Nucleophiles with the Galactosyl-Enzyme Intermediates of E461G and E461Q b‑Galactosidases", Biochemistry, 35, 12387-12401 (1996).

(57)M. M. Toteva and J. P. Richard, "Mechanism for Nucleophilic Substitution and Elimination Reactions at Tertiary Carbon in Largely Aqueous Solutions: Lifetime of a Simple Tertiary Carbocation", Journal of the American Chemical Society, 118, 11434-11445 (1996).

(58) J. P. Richard, S. S. Lin and K. B. Williams, "Relative Reactivities of a Strongly Nucleophilic Alkene and Azide Ion in Aqueous Methanol", Journal of Organic Chemistry, 61, 9033-9034 (1996).

(59) J. P. Richard, S.-S. Lin, J. M. Buccigross and T. L. Amyes, "How Does Organic Structure Determine Organic Reactivity? Nucleophilic Substitution and Alkene-Forming Elimination Reactions of α-Carbonyl and a-Thiocarbonyl Substituted Benzyl Derivatives", Journal of the American Chemical Society, 118, 12603-12613 (1996).

(60)A. Rios and J. P. Richard, "Biological Enolates: Generation and Stability of the Enolate of N-Protonated Glycine Methyl Ester in Water", Journal of the American Chemical Society, 119, 8375-8376 (1997).

(61)M. M. Toteva and J. P. Richard, "Mechanistic Imperatives for the Reaction Catalyzed by Isopentenyl Pyrophosphate Isomerase: Free Energy Profile for Stepwise Isomerization in Water Through a Tertiary Carbocation Intermediate", Bioorganic Chemistry, 25, 239-245 (1997).

(62) J. P. Richard, "The Enhancement of Enzymatic Rate Accelerations by Broensted Acid-Base Catalysis", Biochemistry, 37, 4305-4309 (1998).

(63)K. B. Williams and J. P. Richard, "Kinetic Mechanism for Dimerization of an a‑Thioamide Substituted Benzyl Carbocation in Aqueous Solution", Journal of Physical Organic Chemistry, 11, 701-706 (1998).

(64) J. P. Richard, P. Szymanski and K. B. Williams, "Solvent Effects on Carbocation-Nucleophile Addition Reactions: A Comparison of ¼-Nucleophilicity in Aqueous and Organic Solvents", Journal of the American Chemical Society, 120, 10372-10378 (1998).

(65) R. A. McClelland, V. E. Licence, J. P. Richard, K. B. Williams and S.-S. Lin, "Remarkable Kinetic Stability of a-Thiocarbamoyl Substituted 4-Methoxybenzyl Cations", Canadian Journal of Chemistry, 76, 1910-1915 (1998).

(66) J. P. Richard, G. Williams and J. Gao, "Experimental and Computational Determination of the Effect of the Cyano Group on Carbon Acidity in Water", Journal of the American Chemical Society, 121, 715-726 (1999).

(67) J. P. Richard and R. W. Nagorski, "Mechanistic Imperatives for Catalysis of Aldol Addition Reactions: Partitioning of the Enolate Intermediate between Reaction with Broensted Acids and the Carbonyl Group", Journal of the American Chemical Society, 121, 4763-4770 (1999).

(68) T. L. Amyes, T. Mizerski and J. P. Richard, "How Does Organic Structure Determine Organic Reactivity? The Effect of ortho-Dimethyl Groups on the Nucleophilic Substitution and Alkene-Forming Elimination Reactions of Ring-Substituted Cumyl Derivatives", Canadian Journal of Chemistry , 77, 922-933 (1999) [Special Issue dedicated to A. J. Kresge].

(69) J. P. Richard, K. B. Williams and T. L. Amyes, "Intrinsic Barriers for the Reactions of an Oxocarbenium Ion in Water" Journal of the American Chemical Society, 121, 8403-8404 (1999).

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