Zhen
Yan, Ph.D.
Selected
Publications:
1.
Conrow-Graham
M, Williams JB, Martin J, Zhong P, Cao
Q, Rein B, Yan Z (2022) A Convergent mechanism of high risk factors ADNP and POGZ
in neurodevelopmental disorders. Brain 145: 3250-3263.
[PDF file] ***
2.
Wang
ZJ, Shwani T, Liu J, Zhong P, Yang F, Schatz K, Zhang F, Pralle A, Yan Z (2022) Molecular and cellular
mechanisms for differential effects of chronic social isolation stress in males
and females. Molecular Psychiatry 27(7):3056-3068. [PDF file] ***
3.
Li H,
Jiang H, Li H, Li L, Yan Z, Feng J (2022) Generation of human A9 dopaminergic pacemakers from induced pluripotent
stem cells. Molecular Psychiatry (Online ahead of print).
[PDF file] ^^^
4. Wang W, Tan T, Cao Q, Zhang F, Rein B, Duan WM, Yan Z (2022) Histone Deacetylase Inhibition Restores Behavioral and Synaptic Function in a Mouse Model of 16p11.2 Deletion. Int J Neuropsychopharmacol. 25(10):877-889. [PDF file] ***
5.
Sanacora G, Yan Z, Popoli M (2022) The stressed
synapse 2.0: Pathophysiological mechanisms in stress-related neuropsychiatric
disorders. Nature Reviews Neuroscience 23:86-103. [PDF file] ***
6.
Zhong P, Cao Q, Yan
Z (2022) Selective impairment of circuits between prefrontal cortex
glutamatergic neurons and basal forebrain cholinergic neurons in a tauopathy
mouse model. Cerebral Cortex (Online ahead of print). [PDF file] !!!
7.
Rapanelli M, Williams JB, Ma K, Yang F, Zhong P,
Patel R, Kumar M, Qin L, Rein B, Wang ZJ, Kassim B, Javidfar B, Couto L, Akbarian S, Yan Z (2022) Targeting histone demethylase LSD1 for treatment of
deficits in autism mouse models. Molecular Psychiatry (Online ahead
of print). [PDF file] ***
8.
Rein
B, Conrow-Graham M, Frazier A, Cao Q, Yan
Z (2022) Inhibition of histone deacetylase 5 ameliorates abnormalities in 16p11.2 duplication mouse model.
Neuropharmacology 204:108893. [PDF file] ***
9.
Qin
L, Ma K, Yan Z (2022) Rescue
of histone hypoacetylation and social deficits by ketogenic diet in a Shank3
mouse model of autism. Neuropsychopharmacology 47(6):1271-1279. [PDF file] ***
10.
Yan Z
and Rein B (2022) Mechanisms of synaptic transmission dysregulation in the
prefrontal cortex: pathophysiological implications. Molecular
Psychiatry (review) 27(1):445-465. [PDF file] ***
11.
Qin
L, Williams JB, Tan T, Liu T, Cao Q, Ma K, Yan Z (2021) Deficiency of autism risk factor Ash1l in prefrontal cortex induces
epigenetic aberrations and seizures. Nature Communications
12:6589. [PDF file] ***
12.
Wang W, Cao Q, Tan T, Yang F, Williams JB, Yan Z
(2021) Epigenetic treatment of
behavioral and physiological deficits in a tauopathy mouse model. Aging Cell 20(10):e13456. [PDF file]
!!!
13.
William
JB, Cao Q, Yan
Z (2021) Transcriptomic analysis of human brains with Alzheimer's
disease reveals the altered expression of synaptic genes linked to cognitive
deficits. Brain Communications 3(3):fcab123 [PDF file] !!!
14.
Tan
T, Wang W, Liu T, Zhong P, Conrow-Graham M, Tian X, Yan Z (2021) Neural circuits and activity dynamics underlying sex-specific effects of
chronic social isolation stress. Cell
Reports 34:108874. [PDF file] ***
15.
Catlin J, Marziali L, Rein B, Yan Z, Feltri LM, Schaner-Tooley CE (2021) Age-related neurodegeneration and
cognitive impairments of NRMT1 knockout mice are preceded by misregulation of RB and abnormal neural stem cell
development. Cell Death and Disease 12:1014. !!!
16.
Wang
ZJ, Rein B, Zhong P, Williams JB, Cao Q, Yang F, Zhang F, Ma K, Yan Z (2021) Autism risk gene Kmt5b deficiency in prefrontal cortex induces
synaptic dysfunction and social deficits via alterations of DNA repair and gene
transcription. Neuropsychopharmacology 46:1617-1626. [PDF file] ***
17.
Li B,
Jiang H, Li H, Zhang B, Slaughter M, Yan Z, Feng J (2021) Direct
conversion of adult human retinal pigmented epithelium cells to neurons with
photoreceptor properties. Exp Biol Med 246(2):240-248. ^^^
18.
Rein
B, Tan T, Yang F, Wang W, Williams J, Zhang F, Mills A, Yan Z (2021) Reversal of
synaptic and behavioral deficits in a 16p11.2 duplication mouse model via
restoration of the GABA synapse regulator Npas4.
Molecular Psychiatry 26:1967-1979. [PDF file] ***
19.
Zhang
F, Rein B, Zhong P, Shwani T, Conrow-Graham M, Wang ZJ, Yan Z (2021) Synergistic inhibition of histone modifiers produces
therapeutic effects in adult Shank3-deficient
mice. Translational Psychiatry 11(1):99. [PDF file] ***
20.
Wei J, Cheng J, Waddell NJ, Wang ZJ, Pang X, Cao Q,
Liu A, Chitaman JM, Abreu K, Jasrotia
RS, Duffney LJ, Zhang J, Dietz DM, Feng J, Yan Z (2021) DNA methyltransferase 3A
is involved in the sustained effects of chronic stress on synaptic functions
and behaviors. Cerebral Cortex. 31:1998-2012. [PDF file] ***
21.
Rapanelli
M, Tan T, Wang W, Wang X, Zhong P, Wang ZJ, Frick L, Qin L, Ma K, Qu J, Yan
Z (2021) Behavioral, circuitry and molecular aberrations by region-specific
deficiency of the high-risk autism gene Cul3. Molecular Psychiatry
26:1491-1504.
[PDF file]
22.
Cao
Q, Wang W, Williams J, Yang F, Wang ZJ, Yan
Z (2020) Targeting histone K4 trimethylation for treatment of cognitive and
synaptic deficits in mouse models of Alzheimer's disease. Science Advances 6(50):eabc8096. [PDF file] !!!
23.
Rein
B, Ma K, Yan Z (2020) A standardized
social preference protocol for measuring social deficits in mouse models of
autism. Nature Protocols 15:3464-3477. [PDF file] ***
24.
Rein
B and Yan Z (2020) 16p11.2 copy number variations and
neurodevelopmental disorders. Trends
in Neuroscience 43(11):886-901. [PDF file] ***
25.
Lepack
AE, Werner CT, Stewart AF, Fulton SL, Zhong P, Farrelly
LA, Smith ACW, Ramakrishnan A, Lyu Y, Bastle RM,
Martin JA, Mitra S, O'Connor RM, Wang ZJ, Molina H, Turecki
G, Shen L, Yan Z, Calipari ES, Dietz
DM, Kenny PJ, Maze I (2020) Dopaminylation of histone
H3 in ventral tegmental area regulates cocaine seeking. Science 368:197-201. [PDF file] ***
26.
Zhong P, Qin L, Yan
Z (2020) Dopamine differentially regulates response dynamics of PFC
principal neurons and interneurons to optogenetic stimulation of VTA inputs. Cerebral
Cortex 30:4402-4409. [PDF file]
***
27.
Jin J,
Bhatti DL, Lee KW, Medrihan L, Cheng J, Wei J, Zhong
P, Yan
Z, Kooiker
C, Song C, Ahn JH, Obermair
GJ, Lee A, Gresack J, Greengard P, Kim Y (2020) Ahnak scaffolds p11/Anxa2 complex and L-type voltage-gated
calcium channel and modulates depressive behavior. Mol. Psychiatry 25:1035-1049. [PDF file] ***
28.
Wang ZJ, Zhong P, Ma K, Seo JS, Yang F, Hu Z, Zhang F, Lin
L, Wang J, Liu T, Matas E, Greengard P, Yan Z (2020) Amelioration of
autism-like social deficits by targeting histone methyltransferases EHMT1/2 in Shank3-deficient
mice. Mol. Psychiatry 25:2517-2533. [PDF file] ***
29.
Zheng
Y, Liu A, Wang ZJ, Cao Q, Wang W, Lin L, Ma K, Zhang F, Wei J, Matas E, Cheng J, Chen GJ, Wang X, Yan Z (2019)
Inhibition of EHMT1/2 rescues synaptic and cognitive functions for Alzheimer's
disease. Brain 142:787-807. [PDF file] !!!
30.
Martin JA, Werner CT, Mitra S, Zhong P, Wang ZJ, Gobira PH, Stewart AF, Zhang J, Erias K, Siemian JN, Hagarty D, Mueller LE, Neve RL, Li JX, Chandra R, Dietz KC,
Lobo MK, Gancarz AM, Yan Z, Dietz DM (2019) A
novel role for the actin-binding protein drebrin in
regulating opiate addiction. Nature Communications 10:4140. [PDF
file] ***
31.
Qin L, Ma K, Yan Z (2019) Chemogenetic
activation of prefrontal cortex in Shank3-deficient mice ameliorates
social deficits, NMDAR hypofunction and Sgk2 downregulation. iScience 17:24-35. [PDF file] ***
32.
Rein B, Yan Z,
Wang ZJ (2019) Diminished social interaction incentive contributes to social
deficits in mouse models of autism spectrum disorder. Genes Brain Behav. 19(1):e12610. [PDF
file] ***
33.
Lin L, Liu A, Li HQ,
Feng J, Yan Z (2019) Inhibition of histone methyltransferases EHMT1/2
reverses b amyloid-induced loss of AMPAR currents in human stem cell-derived
cortical neurons. J. Alzheimer's Disease 70:1175-1185.
34.
Zhu BL, Long Y, Luo
W, Yan Z, Lai YJ, Zhao LG, Zhou WH, Wang YJ, Shen LL, Liu L, Deng XJ,
Wang XF, Sun F, Chen GJ (2019) MMP13
inhibition rescues cognitive decline in Alzheimer transgenic mice via BACE1
regulation. Brain 142:176-192. [PDF file] !!!
35.
Xiang XJ, Song L,
Deng XJ, Tang Y, Min Z, Luo B, Wen QX, Li KY, Chen J, Ma YL, Zhu BL, Yan Z,
Chen GJ (2019) Mitochondrial methionine sulfoxide reductase B2 links oxidative stress
to Alzheimer's disease-like pathology. Exp Neurol. 318:145-156. [PDF
file] !!!
36.
Lai YJ, Zhu BL, Sun
F, Luo D, Ma YL, Luo B, Tang J, Xiong MJ, Liu L, Long
Y, Hu XT, He L, Deng XJ, Zhang JH, Yang J, Yan Z, Chen GJ (2019)
Estrogen receptor α promotes Cav1.2 ubiquitination and degradation in
neuronal cells and in APP/PS1 mice. Aging Cell 18:e12961. [PDF file] !!!
37.
Tan T, Wang W,
Williams J, Ma K, Cao Q, Yan Z
(2019) Stress exposure in dopamine D4 receptor knockout mice induces
schizophrenia-like behaviors via disruption of GABAergic transmission. Schizophrenia
Bulletin 45:1012-1023. [PDF file] ***
38.
Qin L, Ma K, Wang ZJ,
Hu Z, Matas E, Wei J, Yan Z (2018) Social deficits in Shank3-deficient mouse
models of autism are rescued by histone deacetylase (HDAC) inhibition. Nature
Neurosci. 21:564-575. [PDF file] ***
39.
Ma K, Qin L, Matas M, Duffney
LJ, Liu A, Yan Z (2018) Histone deacetylase inhibitor MS-275 restores social and synaptic function
in a Shank3-deficient mouse model of
autism. Neuropsychopharmacology
43:1779-1788. [PDF file] ***
40.
Wang W, Rein B, Tan T, Zhang F, Qin L, Yan
Z (2018) Chemogenetic activation of prefrontal
cortex rescues synaptic and
behavioral deficits in a mouse model of 16p11.2 deletion syndrome. J. Neurosci. 38:5939-5948. [PDF file] ***
41.
Seo JS, Zhong P, Liu
A, Yan Z, Greengard P (2018) Elevation of p11 in lateral habenula mediates depression-like behavior. Molecular Psychiatry 23:1113-1119.
[PDF file] ***
42.
Tang Y, Min Z, Xiang
XJ, Liu L, Ma YL, Zhu BL, Song L, Tang J, Deng XJ, Yan Z, Chen GJ (2018) Estrogen-related
receptor alpha is involved in Alzheimer's disease-like pathology. Exp
Neurol. 305:89-96. [PDF file] !!!
43.
Wei J, Zhong P, Qin L, Tan T, Yan Z (2017) Chemicogenetic restoration of the prefrontal cortex to amygadala pathway ameliorates stress-induced deficits. Cerebral
Cortex 28:1980-1990. [PDF
file] ***
44.
Zhong P, Hu Z, Jiang
H, Yan Z, Feng J (2017) Dopamine
induces oscillatory activity in human midbrain neurons with Parkin mutations. Cell Reports 19:1033-1044. [PDF
file] ^^^
45.
Seo JS, Wei J, Qin L,
Kim Y, Yan Z, Greengard P (2017)
Molecular and cellular basis for stress-induced depression. Molecular
Psychiatry 22:1440-1447. [PDF file] ***
46.
Cheng J, Liu A, Shi
MY, Yan Z (2017) Disrupted glutamatergic transmission in prefrontal
cortex contributes to behavioral abnormality in an animal model of ADHD. Neuropsychopharmacology
42:2096-2104. [PDF file] ***
47.
Yang J, Liu AY, Tang
B, Luo D, Lai YJ, Zhu BL, Wang XF, Yan Z,
Chen GJ (2017) Chronic nicotine differentially affects murine transcriptome
profiling in isolated cortical interneurons and pyramidal neurons. BMC
Genomics 18:194. !!!
48.
Yan Z, Kim E, Datta D, Lewis D, Soderling S (2016)
Synaptic actin dysregulation, a convergent mechanism of mental disorders? J.
Neuroscience 36:11411-7. [PDF file]
(review) ***
49.
Qin L, Liu W, Ma K,
Wei J, Zhong P, Cho K, Yan Z (2016)
The ADHD-linked human dopamine D4 receptor variant D4.7 induces
over-suppression of NMDA receptor function in prefrontal cortex. Neurobiology
of Disease 95:194-203. [PDF file] ***
50.
Deng Y, Wei J, Cheng
J, Zhong P, Xiong Z, Liu A, Lin L, Chen SD, Yan Z (2016) Partial
amelioration of synaptic and cognitive deficits by inhibiting cofilin
dephosphorylation in an animal model of Alzheimer's disease. J.
Alzheimer's Disease 53:1419-32. [PDF file]
!!!
51.
Wei J, Xiong Z, Lee JB, Cheng J, Duffney
LJ, Matas E, Yan
Z (2016) Histone modification of Nedd4
ubiquitin ligase controls the loss of AMPA receptors and cognitive impairment
induced by repeated stress. J. Neurosci.
36:2119-30. [PDF file] ***
52.
Zhong P, Liu W, Yan Z (2016) Aberrant regulation of
synchronous network activity by the ADHD-associated human dopamine D4 receptor
variant D4.7 in prefrontal cortex. J. Physiol. 594:135-47. [PDF file] ***
53.
Xu Z, Jiang H, Zhong
P, Yan Z, Chen SD, Feng J (2016)
Direct conversion of human fibroblasts to induced serotonergic neurons. Molecular
Psychiatry 21:62-70. [PDF file] ^^^
54.
Zhong P and Yan Z (2016) Distinct physiological effects
of dopamine D4 receptors on prefrontal cortical pyramidal neurons and
fast-spiking interneurons. Cerebral Cortex 26:180-91. [PDF file] ***
55.
Yuen EY, Wei J, Yan Z (2016) Estrogen in prefrontal
cortex blocks stress-induced cognitive impairments in female rats. J. Steroid Biochem. & Mol. Biol. 160:221-6. [PDF file] (review) ***
56.
Duffney LJ, Zhong P, Wei J, Matas E, Cheng J, Qin L, Ma K, Dietz DM, Kajiwara Y, Buxbaum JD, Yan Z (2015) Autism-like deficits in
Shank3-deficient mice are rescued by targeting actin regulators. Cell
Reports 11:1400-1413. [PDF file]
***
57.
Jiang H, Xu Z, Zhong
P, Ren Y, Liang G, Schilling HA, Hu Z, Zhang Y, Wang X, Chen S, Yan Z, Feng J (2015) Cell cycle and p53
gate the direct conversion of human fibroblasts to dopaminergic neurons. Nature Communications 6:10100. [PDF
file] ^^^
58.
Wei J, Graziane NM, Gu Z, and Yan
Z (2015) DISC1 protein regulates GABAA receptor trafficking and
inhibitory synaptic transmission in cortical neurons. J. Biol. Chem. 290:
27680-7. [PDF file] ***
59.
Tang B, Luo D, Yang
J, Xu XY, Zhu BL, Wang X, Yan Z,
Chen GJ (2015) Modulation of AMPA receptor mediated current by nicotinic
acetylcholine receptor in layer I neurons of rat prefrontal cortex. Scientific
Reports 5:14099. [PDF file] ###
60.
Hu Z, Pu J, Jiang H,
Zhong P, Qiu J, Li F, Wang X, Zhang B, Yan Z, Feng J (2015) Generation of naivetropic
induced pluripotent stem cells from Parkinson's disease patients for high
efficiency genetic manipulation and disease modeling. Stem Cells Dev. 24:2591-604. [PDF file] ^^^
61.
Plattner F, Hayashi
K, Hernandez A, Benavides DR, Tassin TC, Tan C, Day
J, Fina MW, Yuen EY, Yan Z, Goldberg
MS, Nairn AC, Greengard P, Nestler
EJ, Taussig R, Nishi A, Houslay MD & Bibb JA
(2015) The role of ventral striatal
cAMP signaling in stress-induced behaviors. Nature Neuroscience
18:1094-100. [PDF file]***
62.
Cheng J, Xiong Z, Duffney LJ, Wei J, Liu
AY, Liu S, Chen GJ, Yan Z (2014) Methylphenidate exerts
dose-dependent effects on glutamate receptors and behaviors. Biol.
Psychiatry 76:953-62. [PDF file] ***
63.
Yuen EY, Qin L, Wei
J, Liu W, Liu A and Yan Z (2014)
Synergistic regulation of glutamatergic transmission by serotonin and
norepinephrine reuptake inhibitors in prefrontal cortical neurons. J.
Biol. Chem. 289:25177-85 [PDF file] ***
64.
Wang Q, Xiao B, Cui
S, Song H, Qian Y, Dong L, An H, Cui Y, Zhang W, He Y, Zhang J, Yang J, Zhang
F, Hu G, Gong X, Yan Z, Zheng Y,
Wang X (2014) Triptolide with multiple modes of action improves learning
performance in the 5XFAD Alzheimer's disease mouse model. Disease Models & Mechanisms 7:1385-95. [PDF file]
!!!
65.
Gu Z, Cheng J, Zhong
P, Qin L, Liu W, Yan Z (2014) Ab
selectively impairs mGluR7 modulation of NMDA signaling in basal forebrain
cholinergic neurons: implication in Alzheimer's disease. J. Neurosci.
34:13614-13628. [PDF file] !!!
66.
Smith KR, Davenport
EC, Wei J, Li X, Pathania
M, Vaccaro V, Yan Z, Kittler JT (2014) GIT1 and βPIX link Rac1 signalling
to GABAA receptor cluster stability and inhibitory synapse strength.
Cell
Reports 9:298-310. [PDF file] ###
67.
Plattner F, Hernandez
A, Kistler TM, Pozo K, Zhong P, Yuen EY, Tan C, Hawasli AH, Cooke SF, Nishi A, Guo A, Weiderhold
T, Yan Z, Bibb JA (2014) Memory
enhancement by targeting Cdk5 regulation of NR2B. Neuron 81:1070-83. [PDF file] ###
68.
Hayashi-Takagi A,
Araki Y, Nakamura M, Vollrath B, Duron SG, Yan
Z, Kasai H, Huganir RL, Campbell DA, Sawa A (2014) PAKs inhibitors ameliorate
schizophrenia-associated dendritic spine deterioration in vitro and in vivo
during late adolescence. Proc. Natl. Acad.
Sci. USA 111:6461-6. [PDF
file] ***
69.
Wei J, Graziane NM, Wang H, Zhong P, Wang Q, Liu W, Hayashi-Takagi
A, Korth C, Sawa A, Brandon
NJ, Yan Z (2014) Regulation of NMDA receptors by Disrupted-in-Schizophrenia-1
(DISC1). Biol. Psychiatry 75:414-24. [PDF
file] ***
70.
Deng Y, Xiong Z, Chen P, Wei J, Chen SD, Yan Z (2014) β-Amyloid Impairs the regulation of NMDA receptors by Glycogen Synthase
Kinase 3. Neurobiol. Aging 35:449-59. [PDF file] !!!
71.
Wei J, Yuen EY, Liu W, Li X, Zhong P, Karatsoreos
IN, McEwen BS, Yan Z (2014) Estrogen
protects against the detrimental effects of repeated stress on glutamatergic
transmission and cognition. Molecular Psychiatry 19:588-98 [PDF file] ***
72.
Duffney LJ, Wei J, Cheng J,
Liu W, Smith KR, Kittler JT, Yan Z (2013) Shank3 deficiency induces NMDA receptor hypofunction
via an actin-dependent mechanism. J. Neurosci. 33:15767-78. [PDF file] ***
73.
Vithlani M, Hines RM, Zhong P, Terunuma
M, Hines DJ, Revilla-Sanchez R, Jurd R, Haydon P,
Rios M, Brandon N, Yan Z, Moss SJ (2013) Effects of BDNF on neurogenesis and depression depend upon phosphorylation of the
GABAAR γ2 subunit. J. Neurosci. 33:15567-77. ***
74.
Cheng J, Liu W, Duffney LJ, Yan Z
(2013) SNARE proteins are essential in the potentiation of NMDAR currents by
group II metabotropic glutamate receptors. J. Physiol. 591:3935-47. [PDF file] ###
75.
Yuen EY, Zhong P, Li
X, Wei J, Yan Z (2013) Restoration
of glutamatergic transmission by dopamine D4 receptors in stressed
animals. J. Biol. Chem. 288:26112-20. [PDF
file] ***
76.
Chen GJ, Xiong Z, Yan Z (2013) Ab impairs
nicotinic regulation of inhibitory synaptic transmission and interneuron
excitability in prefrontal cortex. Molecular Neurodegeneration 8:3. [PDF file] !!!
77.
Yuen EY, Wei J, Liu
W, Zhong P, Li X, Yan Z (2012) Repeated
stress causes cognitive impairment by suppressing glutamate receptor expression
and function in prefrontal cortex. Neuron 73:962-77. [PDF file]. ***
78.
Lee JB, Wei J, Liu W,
Cheng J, Feng J, Yan Z (2012) Histone
Deacetylase 6 gates the synaptic action of acute stress in prefrontal cortex. J.
Physiology 90:1535-46. [PDF file]
***
79.
Yuen EY, Wei J, Zhong
P, Yan Z (2012) Disrupted GABAAR
trafficking and synaptic inhibition in a mouse model of Huntington's disease. Neurobiology
of Disease 46:497-502. [PDF file] !!!
80.
Jiang H, Ren Y, Yuen
EY, Zhong P, Ghaedi M, Hu Z, Azabdaftari
G, Nakaso K, Yan
Z, Feng J (2012) Parkin controls
dopamine utilization in human midbrain dopaminergic neurons. Nature Communications 3:668. [PDF file] ^^^
81.
Gu Z, Liu W, Wei J, Yan
Z (2012) Regulation of NMDA receptors by metabotropic glutamate receptor 7.
J.
Biol. Chem. 287:10265-75. (selected as "Papers of the Week") [PDF file] ###
82.
Yuen EY, Li X, Wei J,
Horiguchi M, Meltzer HY, Yan Z (2012) The novel antipsychotic drug lurasidone enhances NMDA
receptor-mediated synaptic responses. Mol. Pharm. 81:113-9. [PDF file] ***
83.
Popoli M, Yan Z, McEwen BS, Sanacora
G (2011) The stressed synapse: the
impact of stress and glucocorticoids on glutamate transmission. Nature
Reviews Neuroscience 13:22-37. [PDF file]
84.
Yuen EY, Liu W, Karatsoreos IN, Ren Y, Feng J, McEwen BS, Yan Z (2011)
Mechanisms for acute stress-induced enhancement of glutamatergic transmission
and working memory. Mol. Psychiatry 16:156-70. [PDF file] [supporting
information] (cover article) ***
85.
Mandal M, Wei J,
Zhong P, Chen J, Duffney LJ, Liu W, Yuen EY,
Twelvetrees AE, Li S, Li XJ, Kittler JT, Yan Z (2011) Impaired AMPA receptor
trafficking and function by mutant huntingtin. J. Biol. Chem. 286:33719-28.
[PDF file] !!!
86.
Zhong P, Yan Z (2011) Differential regulation of
the excitability of prefrontal cortical fast-spiking interneurons and pyramidal
neurons by serotonin and fluoxetine. PLoS One 6:e16970. [PDF file] ###
87.
Yuen EY, Yan Z (2011) Cellular mechanisms for
the dopamine D4 receptor-induced homeostatic regulation of AMPA receptors. J.
Biol. Chem. 286:24957-65. [PDF file] ###
88.
Wang D, Yuen EY, Zhou Y, Yan Z, Xiang
YK (2011) Amyloid {beta} peptide1-42 induces internalization and degradation of
β2 adrenergic receptor
in prefrontal cortical neurons. J Biol Chem. 286:31852-63. [PDF file]
89.
Liu W, Dou F, Feng
J, Yan Z (2011) RACK1 is involved in β-amyloid impairment of muscarinic
regulation of GABAergic transmission. Neurobiol.
Aging 32:1818-26.
90.
Yuen EY, Zhong P, Yan
Z (2010) Homeostatic regulation of glutamatergic transmission by dopamine
D4 receptors. Proc. Natl. Acad. Sci. USA 107:22308-13.
91.
Wang Q, Charych EI, Pulito VL, Lee J, Graziane NM, Crozier RA, Revilla-Sanchez R, Kelly M, Dunlop
AJ, Murdoch H, Taylor N, Xie Y, Pausch M,
Hayashi-Takagi A, Bates B, Kariya K, Sawa A, Weinberg RJ, Moss SJ, Houslay
MD, Yan Z, Brandon NJ (2011) The psychiatric disease risk factors DISC1
and TNIK interact to regulate synapse composition and function. Mol. Psychiatry 16:1006-23. [PDF file]
92.
Liu W, Yuen EY, Yan Z (2010) The stress hormone
corticosterone increases synaptic AMPA receptors via SGK regulation of the
GDI-Rab4 complex. J. Biol. Chem. 285:6101-8. [PDF
file] ***
93.
Wei J, Liu W, Yan Z (2010) Regulation of AMPA receptor trafficking and function by glycogen
synthase kinase 3. J. Biol. Chem. 285:26369-76.
94.
Yuen EY, Liu W, Kafri T, van Praag H, Yan Z
(2010) Regulation of AMPA receptor channels and synaptic plasticity by cofilin
phosphatase Slingshot in cortical neurons.. J.
Physiol. 588:2361-71. [PDF file] ###
95.
Twelvetrees AE, Yuen
EY, Arancibia-Carcamo IL, Rostaing
P, Lumb MJ, Humbert S, Triller A, Saudou
F, Yan Z, Kittler JT (2010) Delivery of
GABAARs to synapses is mediated by HAP1-KIF5 and disrupted by mutant
huntingtin. Neuron 65:53-65. [PDF file] !!!
96.
Hayashi-Takagi A,
Takaki M, Graziane NM, Seshadri S, Murdoch H, Dunlop
AJ, Makino Y, Seshadri AJ, Ishizuka K, Srivastava DP, Xie
Z, Baraban JM, Houslay MD, Tomoda T, Brandon NJ, Kamiya A, Yan
Z, Penzes P, Sawa A
(2010) Disrupted-in-Schizophrenia-1 (DISC1) regulates spines of the glutamate
synapse via Rac1. Nat. Neurosci. 13:327-32.
97.
Joiner MA, Lise MF,
Yuen EY, Kam A, Hall DD, Malik ZA, Qian H, Chen Y, Ulrich JD, Burette AC, Weinberg RJ, Law PY, El-Husseini
A, Yan Z, Hell JW (2010) Assembly of a β2-adrenergic receptor- GluR1 signaling complex for localized cAMP
signaling. EMBO J 29:482-95.
98.
Yuen EY, Liu W, Karatsoreos IN, Feng J, McEwen BS, Yan Z (2009)
Acute stress enhances glutamatergic transmission in prefrontal cortex and
facilitates working memory. Proc. Natl. Acad. Sci. USA
106:14075-9.
99.
Mandal M and Yan Z
(2009) PIP2 regulation of NMDA receptor channels in cortical
neurons. Mol. Pharm. 76:1349-59.
100.
Arancibia-Carcamo IL, Yuen EY, Muir J,
Lumb MJ, Michels G, Smart
TG, Yan Z, Kittler JT, Moss SJ (2009) Ubiquitin-dependent
targeting of GABAARs for lysosomal degradation regulates the efficacy of
neuronal inhibition. Proc. Natl. Acad. Sci. USA 106:17552-7. [PDF
file] ###
101.
Saliba RS, Gu Z, Yan Z,
Moss SJ (2009) Blocking L-type voltage gated Ca2+ channels with
dihydropyridines reduces gamma-aminobutyric acid type A receptor expression and
synaptic inhibition. J Biol Chem. 284:32544-50. ###
102.
Huang YH, Lin Y, Mu
P, Marie H, Liu W, Yan Z, Sorg BA, Schluter
O, Zukin
SR, Dong Y (2009) Exposure to cocaine generates nascent synapses in the nucleus
accumbens. Neuron. 63:40-7. [PDF file] ***
103.
Yuen EY, Yan Z
(2009) Dopamine D4 receptors regulate AMPAR trafficking and glutamatergic
transmission in GABAergic interneurons of prefrontal cortex. J. Neurosci. 29:550-62. [PDF file] ###
105.
Graziane N, Yuen EY, Yan Z (2009) Dopamine D4 receptors
regulate GABAA receptor trafficking and function via an actin/cofilin/myosin-dependent mechanism. J.
Biol. Chem. 284:8329-36. [PDF file] ###
106.
Smith KR, McAinsh K, Chen G, Arancibia-Carcamo
IL, Haucke V, Yan
Z, Moss SJ, Kittler JT (2008) Regulation of inhibitory
synaptic transmission by a conserved atypical AP2 interaction within GABAA
receptor β and γ- subunits. Neuropharmacology 55:844-50. ###
107.
Yuen EY, Jiang Q,
Chen P, Feng J, Yan Z (2008) Activation of 5-HT2A/C receptors
counteracts 5-HT1A regulation of NMDAR channels in pyramidal neurons of
prefrontal cortex. J. Biol. Chem. 283:17194-204. [PDF file] ###
108.
Zhong P, Liu W, Gu Z,
Yan Z (2008) Serotonin facilitates LTD induction in prefrontal cortex
via p38 MAPK/Rab5-mediated enhancement of AMPA receptor internalization. J.
Physiol. 586:4465-79. [PDF file] ###
109.
Yuen EY, Ren Y, Yan
Z (2008) PSD-95 and calcineurin control the sensitivity of NMDA receptors
to calpain cleavage in cortical neurons. Mol. Pharmacol.
74:360-370. [PDF file] ###
110.
Zhong P, Yuen EY, Yan
Z (2008) Modulation of neuronal excitability by serotonin-NMDA interactions
in prefrontal cortex. Mol. and Cell. Neurosci.
38:290-9.[PDF file] ###
111.
Kittler JT, Chen G, Kukhtina V, Vahedi-Faridi A, Gu
Z, Tretter V, Smith K, McAinsh
K, Arancibia-Carcamo L, Saenger
W, Haucke V, Yan Z, Moss SJ (2008) Regulation of
inhibitory synaptic transmission by GABAA receptor γ2 subunit specific phospho-dependent
binding of a YECL motif to the clathrin adaptor AP2. Proc.
Natl. Acad. Sci. USA 105:3616-21. ###
112.
Chen G, Chen P, Tan
H, Ma D, Dou F, Feng J, Yan Z (2008) Regulation of the NMDA
receptor-mediated synaptic response by acetylcholinesterase inhibitors and its
impairment in an animal model of Alzheimer's disease. Neurobiol.
Aging 29:1795-804. [PDF file] !!!
113.
Chen P, Gu Z, Liu W, Yan
Z (2007) Glycogen synthase kinase 3 regulates NMDA receptor channel
trafficking and function in cortical neurons. Mol. Pharm.
72:40-51. [PDF file] ###
114.
Benavides DR, Quinn
JJ, Zhong P, Hawasli AH, Kansy
JW, DiLeone R, Yan Z, Taylor JR, Bibb JA
(2007) Cyclin-dependent protein kinase 5 controls cocaine responses, motivation
for reward, and striatal neuron excitability. J. Neurosci.
27:12967-76. [PDF file] ***
115.
Yuen EY, Liu W, Yan
Z (2007) The phosphorylation state of GluR1 subunits determines the susceptibility
of AMPA receptors to calpain cleavage. J. Biol. Chem.
282:16434-40. [PDF file] ###
116.
Yuen EY, Gu Z, Yan
Z (2007) Calpain regulation of AMPA receptor channels in cortical pyramidal
neurons. J. Physiol. 580:241-54. [PDF file] ###
117.
Gu Z, Jiang Q, Yan
Z (2007) RGS4 modulates serotonin signaling in prefrontal cortex and links
to serotonin dysfunction in a rat model of schizophrenia. Mol. Pharmacol. 71:1030-9. [PDF file] ***
118.
Kastning K, Kukhtina V, Kittler JT, Chen G, Pechstein A, Enders S, Lee SH, Sheng M, Yan Z, Haucke V (2007) Molecular determinants for the interaction
between AMPA receptors and the clathrin adaptor
complex AP-2. Proc. Natl. Acad. Sci. USA 104:2991-6. [PDF file] ###
119.
Liu W, Yuen EY, Allen
PB, Feng J, Greengard P, Yan Z (2006) Adrenergic modulation of NMDA
receptors in prefrontal cortex is differentially regulated by RGS proteins and spinophilin. Proc. Natl. Acad. Sci. USA 103:18338-43.
[PDF file] ###
120.
Allen PB, Zachariou V, Svenningsson P,
Lepore AC, Centonze D, Costa C, Rossi S, Bender G,
Chen G, Feng J, Snyder GL, Bernardi G, Nestler EJ, Yan Z, Calabresi
P, Greengard P (2006) Distinct roles for spinophilin
and neurabin in dopamine-mediated plasticity. Neuroscience
140:897-911. ###
121.
Jiang Q, Yan Z,
Feng J (2006) Neurotrophic factors protect against rotenone toxicity on
dopaminergic neurons through a microtubule-dependent mechanism. J. Biol.
Chem. 281:29231-400. [PDF file] !!!
122.
Jiang Q, Yan Z,
Feng J (2006) Activation of group III metabotropic glutamate receptors
attenuates rotenone toxicity on dopaminergic neurons through a
microtubule-dependent mechanism. J. Neurosci.
26:4318-28. [PDF file] ###
123.
Chen G, Kittler JT, Moss SJ, Yan Z (2006) Dopamine D3
receptors regulate GABA(A) receptor function through a phospho-dependent
endocytosis mechanism in nucleus accumbens. J. Neurosci. 26:2511-9. [PDF file] ###
124.
Gu Z, Jiang Q, Yuen
EY, Yan Z (2006) Activation of dopamine D4 receptors induces synaptic
translocation of CaMKII in cultured prefrontal cortical neurons. Mol. Pharmacol. 69:813-22. [PDF file] ###
125. Wang X, Gu Z, Zhong P, Chen G, Feng J, Yan Z (2006) Aberrant
regulation of NMDAR functions by dopamine D4 receptors in rats after
phencyclidine exposure. Mol. and Cell. Neurosci.
31:15-25. [PDF file] ***
126.
Yuen EY, Jiang Q, Chen
P, Gu Z, Feng J, Yan Z (2005) Serotonin 5-HT1A receptors
regulate NMDA receptor channels through a microtubule-dependent mechanism. J.
Neurosci. 25: 5488-501. [PDF file] ###
127.
Kittler JT, Chen G, Honing
S, Bogdanov Y, McAinsh K, Arancibia-Carcamo
IL, Jovanovic JN, Pangalos MN, Haucke
V, Yan Z and Moss SJ (2005) Phospho-dependent binding of the clathrin AP2 adaptor complex to GABA(A) receptors regulates
the efficacy of inhibitory synaptic transmission. Proc. Natl. Acad. Sci.
USA 102:14871-6. [PDF file] ###
128.
Gu Z, Jiang Q, Fu
AKY, Ip NY, Yan Z (2005) Regulation of NMDA receptors by neuregulin signaling
in prefrontal cortex. J. Neurosci. 25:
4974-84. [PDF file] ***
129.
Yuen EY, Jiang Q,
Feng J, Yan Z (2005) Microtubule regulation of NMDA receptor channels in
neurons. J. Biol. Chem. 280:29420-7. [PDF file] ###
130.
Wu HY, Yuen EY, Lu
YF, Matsushita M, Matsui H, Yan Z, Tomizawa
K (2005) Regulation of NMDA receptors by calpain in cortical neurons. J.
Biol. Chem. 280: 21588-93. [PDF file]
131.
Chen P, Yan Z (2005)
Corticotropin-releasing factor in brain function. In: Handbook of
Neurochemistry and Molecular Neurobiology (3rd Edition), (Editor-in-Chief: Abel
Lajtha) Kluwer Academic/Plenum Publishers,
132.
Tyszkiewicz JP, Yan Z
(2005) β-Amyloid peptides impair PKC-dependent functions of metabotropic glutamate
receptors in prefrontal cortical neurons. J. Neurophysiol.
93: 3102-11. [PDF
file] !!!
133.
Gu Z and Yan Z (2004) Bi-directional regulation
of CaMKII activity by dopamine D4 receptors in prefrontal cortex. Mol. Pharmacol. 66: 948-55. [PDF file] ***
134.
Zhong P and Yan Z (2004) Chronic antidepressant
treatment alters the serotonergic regulation of GABA transmission in prefrontal
cortical pyramidal neurons. Neurosci.
129: 65-73. [PDF file]
135.
Tan H, Zhong P, Yan Z (2004) Corticotropin-releasing
factor and acute stress prolongs serotonergic regulation of GABA transmission
in prefrontal cortical pyramidal neurons. J. Neurosci. 24:
5000-8. [PDF file]
136.
Yan Z and Feng J (2004) Alzheimer's disease: interactions between cholinergic
functions and β-amyloid. Current Alzheimer Research (review) 1: 241-8. [PDF file] !!!
137.
Chen G, Greengard P, Yan Z (2004) Potentiation of NMDA receptor
currents by dopamine D1 receptors in prefrontal cortex. Proc. Natl. Acad.
Sci. USA 101: 2596-600. [PDF file] ***
138.
Tyszkiewicz JP, Gu Z, Wang X,
Cai X, Yan Z (2004) Group II
metabotropic glutamate receptors enhance NMDA receptor currents via a protein
kinase C-dependent mechanism in pyramidal neurons of rat prefrontal cortex. J.
Physiology (London) 554: 765-77. [PDF file] ***
139.
Wang X, Zhong P, Gu
Z, Yan Z (2003) Regulation of NMDA receptors by dopamine D4 signaling in
prefrontal cortex. J. Neurosci. 23: 9852-61. [PDF
file] ***
140.
Zhong P, Gu Z, Wang
X, Jiang H, Feng J, Yan Z (2003) Impaired modulation of GABAergic
transmission by muscarinic receptors in a mouse transgenic model of Alzheimer's
disease. J. Biol. Chem. 278: 26888-96. [PDF file] !!!
141.
Davila V, Yan Z,
Craciun LC, Logothetis D,
Sulzer D (2003) D3 dopamine autoreceptors do not activate
GIRK channel currents in substantia nigra dopamine neurons. J. Neurosci. 23: 5693-7. ***
142.
Gu Z, Zhong P, Yan
Z (2003) Activation of muscarinic receptors inhibits β-amyloid peptide - induced signaling
in cortical slices. J. Biol. Chem. 278: 17546-56. [PDF file]
143.
Ma X, Zhong P, Gu Z,
Feng J, Yan Z (2003) Muscarinic potentiation of GABAA receptor currents
is gated by insulin signaling in the prefrontal cortex. J. Neurosci. 23: 1159-68. [PDF
file] !!!
144.
Wang X, Zhong P, Yan
Z (2002) Dopamine D4 receptors modulate GABAergic signaling in pyramidal
neurons of prefrontal cortex. J. Neurosci.22: 9185-93. [PDF file]
145.
Cai X, Gu Z, Zhong P,
Ren Y, Yan Z (2002) Serotonin 5-HT(1A) receptors regulate AMPA receptor
channels through inhibiting CaMKII in prefrontal cortical pyramidal neurons. J.
Biol. Chem. 277: 36553-62. [PDF file] ###
146.
Yan Z (2002) Regulation of GABAergic inhibition by serotonin signaling in
prefrontal cortex: molecular mechanisms and functional implications. Molecular
Neurobiology (review) 26: 203-16.
147.
Cai X, Flores-Hernandez
J, Feng J, Yan Z (2002) Activity-dependent bi-directional regulation of
GABAA receptor channels by serotonin 5-HT4 receptors in pyramidal neurons of
the prefrontal cortex. J. Physiology (London) 540: 743-59. [PDF file]
148.
Yan Z, Chi P, Bibb JA, Ryan TA, Greengard P (2002) Roscovitine:
a novel regulator of P/Q-type calcium channels and transmitter release in
central neurons. J. Physiology (London) 540: 761-70. ###
150.
Liu F, Ma X, Ule J,
Nishi A, Bibb JA, DeMaggio AJ, Yan Z, Nairn AC, Greengard P (2001) Regulation of cyclin dependent
kinase 5 and casein kinase I by metabotropic glutamate receptors. Proc.
Natl. Acad. Sci. USA 98: 11062-8.
151.
Yan Z, Flores-Hernandez J, Surmeier DJ (2001)
Coordinated expression of muscarinic receptor mRNAs in striatal medium spiny
neurons. Neuroscience 103: 1017-24. ###
153.
Bibb JA, Yan Z,
Svenningsson P, Snyder GL, Pieribone
VA, Nairn AC, Messer A, Greengard P (2000) Severe
deficiencies in dopamine signaling in presymptomatic
Huntington's disease mice. Proc. Natl. Acad. Sci. USA 97:
6809-14. [PDF
file] !!!
154.
Feng J, Yan Z,
Ferreira AB, Tomizawa K, Liauw
JA, Zhuo M, Allen PB, Ouimet CC, Greengard P (2000) Regulation
of the formation and function of dendritic spines by spinophilin.
Proc. Natl. Acad. Sci. USA 97: 9287-92.
155.
Flores-Hernandez J,
Hernandez S, Snyder GL, Yan Z, Fienberg AA, Moss SJ, Greengard P, Surmeier DJ (2000) D1 dopamine receptor activation reduces
GABAA receptor currents in neostriatal neurons
through a PKA/DARPP-32 /PP-1 signaling cascade. J. Neurophysiology
83: 2996-3004. ###
156.
157.
158.
Bibb JA, Snyder GL,
Nishi A, Yan Z, Meijer L, Fienberg AA et al. (1999) Phosphorylation of
DARPP-32 by Cdk5 modulates dopamine signalling in
neurons. Nature 402: 669-71.
159.
Stwart A, Yan Z, Surmeier DJ, Foehring R (1999)
Muscarine modulates Ca2+ currents in rat sensorymotor
pyramidal cells via two distinct pathways. J. Neurophysiol.
81: 72-84. ###
160.
Mermelstein PG, Song WJ, Tkatch T, Yan Z, Surmeier
DJ (1998) Inwardly rectifying potassium (IRK) currents are correlated with IRK
subunit expression in rat nucleus accumbens medium
spiny neurons. J. Neurosci. 18:
6650-61. ###
162.
163.
164.
Surmeier DJ, Song WJ, Yan
Z (1996) Coordinated expression of dopamine receptors in neostriatal medium spiny neurons. J. Neurosci. 16: 6579-91.
165.
Yan Z and Surmeier DJ (1996) Muscarinic (m2/m4)
receptors reduce N- and P-type Ca2+ currents in rat neostriatal
cholinergic interneurons through a fast, membrane-delimited, G-protein pathway.
J. Neurosci. 16: 2592-604.
***:
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