Zhen Yan, Ph.D.

 

Biographical Information:

Education:

B.Sc. Biomedical Engineering, Xi'an Jiaotong University, Xi'an, China (1986-1990)

 

M.E. Computer Engineering, Southeast University, Nanjing, China (1990-1993)

                       

Ph.D. Neurobiology, University of Tennessee, College of Medicine, Memphis, TN (1994-1997) Mentor: Dr. James Surmeier

 

Academic Appointments:

Postdoctoral Associate, The Rockefeller Univ., Lab. of Molecular & Cellular Neuroscience (1997-2000) Mentor: Dr. Paul Greengard (2000 Nobel Laureate) 

 

Assistant Professor, State Univ. of New York at Buffalo, School of Medicine, Dept. of Physiology and Biophysics (2000-2004)

 

Associate Professor, State Univ. of New York at Buffalo, School of Medicine, Dept. of Physiology and Biophysics (2004-2008)

 

Professor, State Univ. of New York at Buffalo, School of Medicine, Dept. of Physiology and Biophysics (2008-present)

 

SUNY Distinguished Professor, State Univ. of New York at Buffalo, School of Medicine, Dept. of Physiology and Biophysics (2018-present)

 

Grants:

Currently Active:

NIH, R01-AG064656, "Targeting Histone K4 Methylation for Treatment of Alzheimer's Disease and Related Dementia" (2019-2024, PI: Yan)

 

NIH, R01-MH126443, "Synaptic and Genetic Mechanisms of Sex-Specific Effects of Stress" (2021-2026, PI: Yan)

 

NIH, R01-AG079797, "Transcriptomic and Circuitry Aberrations in Alzheimer's Disease" (2022-2027, PI: Yan, MPI: Feng)

 

NIH, R01-NS127728, "Epigenetics-Based Autism Treatment with Animal Models and Human Stem Cells" (2023-2028, PI: Yan, MPI: Feng)

 

Completed:

NIH, R01-AG056060, "A Novel Epigenetic Mechanism for Alzheimer's Disease" (2017-2022, PI: Yan)

 

NIH, R21-AG067597, "New Treatment Strategy for Alzheimer's Disease" (2020-2022, PI: Feng; MPI: Yan)

 

NIH, R01-MH108842, "Physiological and Pathophysiological Basis of Stress" (2015-2020, PI: Yan)

 

NIH, R01-DA037618, "Functions of Dopamine D4 Receptors in Prefrontal Cortex" (2014-2019, PI: Yan)

 

NIH, R41-MH112237, "Discovery of Novel Drugs for Autism" (2017-2019, PI: Yan)

 

NLFM, "Novel Therapeutic Strategies for Autism" (2016-2019, PI: Yan)

 

NIH, R21-MH101690, "Synaptic Functions of Disrupted-in-Schizophrenia-1 (DISC1)" (2013-2015, PI: Yan)

 

VA, 1I01BX001633, "A Novel Pathophysiological Mechanism of Alzheimer's Disease" (2013-2017, PI: Yan)

 

NIH, R01-MH085774, "Synaptic Changes by Stress in Prefrontal Cortex" (2010-2014, PI: Yan)

 

NIH, R21-NS069929, "Aberrant GABAAR Trafficking and Synaptic Inhibition in Huntington's Disease" (2010-2012, PI: Yan)      

 

NIH, R01-MH084233, "Functions of Dopamine D4 Receptors in Prefrontal Cortex" (2008-2013, PI: Yan)

 

American Heart Association, "A New Protective Mechanism for Stoke: Calpain Regulation of Glutamate Receptor Functions" (2005-2008, PI: Yan)  

 

NIH, R01-NS048911, "Functions of D4 Dopamine Receptors in Prefrontal Cortex" (2004-2008, PI: Yan)

 

NIH, R01-AG021923, "The Role of Cholinergic Functions in Alzheimer's Disease" (2003-2008, PI: Yan)

 

NIH, R01-MH063128, "Neuromodulator Actions in Prefrontal Cortical Neurons" (2001-2006, PI: Yan)

 

Aventis Pharmaceuticals Inc., "Testing of Compounds for Identification of Novel Antidepressants" (2001-2004, PI: Yan)

 

National Science Foundation, IBN-0117026, "Modulation of Ion Channels by Kinase/Phosphatase Signaling Complexes in CNS Neurons" (2001-2005, PI: Yan)

 

Awards and Services:

Regular Member, PMDA (Pathophysiological Basis of Mental Disorders and Addiction) Study Section, National Institutes of Health (2015-2021)

SUNY Chancellor's Awards for Excellence in Scholarship and Creative Activities (2013)    

SUNY-Buffalo Exceptional Scholars - Sustained Achievement Award (2012)    

Editorial Board Member, J. Biol. Chem. (2010-2015)         

Regular Member, NTRC (Neurotransporters, Receptors, and Calcium Signaling) Study Section, National Institutes of Health (2009-2013)

The George W. Thorn Young Investigator Award (2006)

National Alliance for Research on Schizophrenia and Depression (NARSAD) Independent Investigator Award (2004-2006)

SUNY-Buffalo Exceptional Scholars - Young Investigator Award (2002)

Top 100 Federal Grantee (2002-present)       

NARSAD Young Investigator Award (1999-2001)

National Parkinson Foundation Menek Goldstein Research Scholar Award (1998)