Zhen Yan, Ph.D.
Biographical
Information:
Education:
B.Sc. Biomedical Engineering, Xi'an
M.E. Computer Engineering, Southeast
Ph.D. Neurobiology, University
of
Academic
Appointments:
Postdoctoral
Associate, The
Assistant Professor,
State Univ. of New York at
Associate Professor, State Univ. of New York at Buffalo, School of Medicine, Dept. of Physiology and Biophysics (2004-2008)
Professor, State Univ. of New York at Buffalo, School of Medicine, Dept. of Physiology and Biophysics (2008-present)
SUNY Distinguished Professor, State Univ. of New York at Buffalo, School of Medicine, Dept. of Physiology and Biophysics (2018-present)
Grants:
Currently Active:
NIH, R01-AG064656, "Targeting Histone K4 Methylation for Treatment of Alzheimer's
Disease and Related Dementia" (2019-2024, PI: Yan)
NIH, R01-MH126443, "Synaptic and Genetic
Mechanisms of Sex-Specific Effects of Stress" (2021-2026, PI: Yan)
NIH, R01-AG079797, "Transcriptomic and
Circuitry Aberrations in Alzheimer's Disease" (2022-2027, PI: Yan, MPI:
Feng)
Completed:
NIH,
R01-AG056060, "A Novel Epigenetic Mechanism for Alzheimer's Disease" (2017-2022, PI: Yan)
NIH, R21-AG067597, "New Treatment Strategy for Alzheimer's
Disease" (2020-2022, PI: Feng; MPI: Yan)
NIH,
R01-MH108842, "Physiological and Pathophysiological Basis of Stress" (2015-2020, PI: Yan)
NIH, R01-DA037618, "Functions of Dopamine D4
Receptors in Prefrontal Cortex"
(2014-2019,
PI: Yan)
NIH, R41-MH112237, "Discovery of Novel Drugs for Autism" (2017-2019, PI: Yan)
NLFM, "Novel Therapeutic Strategies for
Autism" (2016-2019, PI: Yan)
NIH, R21-MH101690,
"Synaptic Functions of
Disrupted-in-Schizophrenia-1 (DISC1)" (2013-2015, PI: Yan)
VA, 1I01BX001633, "A Novel Pathophysiological Mechanism of
Alzheimer's Disease" (2013-2017, PI: Yan)
NIH, R01-MH085774, "Synaptic
Changes by Stress in Prefrontal Cortex" (2010-2014, PI: Yan)
NIH, R21-NS069929, "Aberrant GABAAR Trafficking and
Synaptic Inhibition in Huntington's Disease" (2010-2012, PI:
Yan)
NIH, R01-MH084233, "Functions of Dopamine D4
Receptors in Prefrontal Cortex" (2008-2013, PI: Yan)
American Heart Association, "A New Protective Mechanism for Stoke:
Calpain Regulation of Glutamate Receptor Functions" (2005-2008, PI: Yan)
NIH, R01-NS048911, "Functions of D4 Dopamine
Receptors in Prefrontal Cortex" (2004-2008, PI: Yan)
NIH, R01-AG021923, "The Role of Cholinergic Functions in
Alzheimer's Disease"
(2003-2008,
PI: Yan)
NIH, R01-MH063128, "Neuromodulator Actions in Prefrontal
Cortical Neurons"
(2001-2006,
PI: Yan)
Aventis Pharmaceuticals Inc., "Testing of Compounds for Identification of
Novel Antidepressants"
(2001-2004,
PI: Yan)
National Science Foundation, IBN-0117026, "Modulation of Ion Channels by
Kinase/Phosphatase Signaling Complexes in CNS Neurons" (2001-2005, PI: Yan)
Awards
and Services:
Regular Member, PMDA (Pathophysiological Basis of Mental Disorders and Addiction) Study Section, National Institutes of Health (2015-2021)
SUNY Chancellor's Awards for Excellence in Scholarship and Creative Activities (2013)
SUNY-Buffalo Exceptional Scholars - Sustained Achievement Award (2012)
Editorial Board Member, J. Biol. Chem. (2010-2015)
Regular Member, NTRC (Neurotransporters, Receptors, and Calcium Signaling) Study Section, National Institutes of Health (2009-2013)
The George W. Thorn Young Investigator Award (2006)
National
SUNY-Buffalo Exceptional Scholars - Young Investigator Award (2002)
Top 100 Federal Grantee (2002-present)
NARSAD Young Investigator Award (1999-2001)
National Parkinson Foundation Menek Goldstein Research Scholar Award (1998)