Bo An

Introduction

Dr. Bo An obtained his bachelor's degree in Pharmaceutics at China Pharmaceutical University in 2009. With a couple of years of industry experiences on drug developments, he joined the Pharmaceutical Sciences Department, University at Buffalo, in 2012. Bo received his MS degree in Pharmaceutical Sciences in 2014, and PhD degree in Pharmaceutical Sciences in 2018. Dr. An joined GSK in 2018. His research interests are targeted quantification for pharmaceutical investigations, including drug (small molecule and biotherapeutics) quantification, biomarker identification, validation and quantification, and PK/PD investigation.

Publications

1. An, B., Zhang, M., Qu, Y., Qu, J. (2019) High-throughput, sensitive quantification of protein therapeutics and targets using an antibody-free, multiple-mechanism enrichment via strategically regulated pH, ionic and organic strengths. Anal Chem. 91(5):3475-3483.

2. Zhang, M.*, An, B.*, Qu, Y., Shen, S., Fu, W., Chen, Y. J., . . . Qu, J. (2018). Sensitive, High-Throughput, and Robust Trapping-Micro-LC-MS Strategy for the Quantification of Biomarkers and Antibody Biotherapeutics. Anal Chem, 90(3), 1870-1880.

3. Engler, F. A., Polli, J. R., Li, T., An, B., Otteneder, M., Qu, J., & Balthasar, J. P. (2018) Pharmacokinetics of a “Catch-and-Release” Anti-CEA mAb in Mouse Models of Colorectal Cancer. J Pharmacol Exp Ther.

4. Pu, J., An, B., Vazvaei, F., Qu, J. (2018). Enrichment of protein therapeutics and biomarkers for LC/MS quantification. Bioanalysis.

5. Qu, M.*, An, B.*, Shen, S., Zhang, M., Shen, X., Duan, X., . . . Qu, J. (2017). Qualitative and quantitative characterization of protein biotherapeutics with liquid chromatography mass spectrometry. Mass Spectrom Rev, 36(6), 734-754.

6. Tu, C., Mojica, W., Straubinger, R. M., Li, J., Shen, S., Qu, M., . . . An, B., Qu, J. (2017). Quantitative proteomic profiling of paired cancerous and normal colon epithelial cells isolated freshly from colorectal cancer patients. Proteomics Clin Appl, 11(5-6).

7. Fu, W.*, An, B.*, Wang, X., & Qu, J. (2017). Key considerations for LC-MS analysis of protein biotherapeutics in tissues. Bioanalysis, 9(18), 1349-1352.

8. Shen, S., An, B., Qu, J. 2017. “Sample Preparation Methods for Targeted Biomarker Quantification by LC‐MS.” Targeted Biomarker Quantitation by LC–MS, 79-106.

9. An, B.*, Zhang, M. *, Johnson, R. W., & Qu, J. (2015). Surfactant-aided precipitation/on-pellet-digestion (SOD) procedure provides robust and rapid sample preparation for reproducible, accurate and sensitive LC/MS quantification of therapeutic protein in plasma and tissues. Anal Chem, 87(7):4023-4029.

10. An, B., Zhang, M., & Qu, J. (2015). "ADME and Translational Pharmacokinetics/Pharmacodynamics of Therapeutic Proteins: Applications in Drug Discovery and Development." Chapter 21. LC/MS versus Immune‐Based Bioanalytical Methods in Quantitation of Therapeutic Biologics in Biological Matrices. ISBN: 978-1-118-89864-2.

11. An, B., Zhang, M., & Qu, J. (2014). Toward sensitive and accurate analysis of antibody biotherapeutics by liquid chromatography coupled with mass spectrometry. Drug Metab Dispos, 42(11), 1858-1866.

12. Nouri-Nigjeh, E., Zhang, M., Ji, T., Yu, H., An, B., Duan, X., . . . Qu, J. (2014). Effects of calibration approaches on the accuracy for LC-MS targeted quantification of therapeutic protein. Anal Chem, 86(7), 3575-3584.