Xiaomeng Shen

Introduction

I received my bachelor degree from Nanjing University in 2011, majoring in biological science. My undergraduate research is about signaling transduction pathways involved in tumor progression mechanisms. I'm pursuing my PhD degree in SUNY at Buffalo, biomedical science. When I'm doing rotation in Dr. Qu's lab, I find that I'm interested in the topic using LC-MS analytic method to characterize,identify and quantify of proteins. The research done in the lab has strong application prospects and closely related to therapeutic field.

Selected Publications

1. Nouri-Nigjeh E, Sukumaran S, Tu C, Li J, Shen X, Duan X, DuBois DC, Almon RR, Jusko WJ, Qu J*. Highly Multiplexed and Reproducible Ion Current-Based Strategy for Large-Scale Quantitative Proteomics and the Application to Protein Expression Dynamics Induced by Methylprednisolone in 60 Rats. Anal Chem. 86(16):8149-57 (2014)

2. Shen X, Young R, Canty JM, Qu J*. Quantitative proteomics in cardiovascular research: Global and targeted strategies. Proteomics Clin Appl. 8(7-8):488-505 (2014)

3. Qu J*, Young R, Page BJ, Shen X, Tata N, Li J, Duan X, Fallavollita JA, Canty JM Jr. Reproducible Ion-Current-Based Approach for 24-Plex Comparison of the Tissue Proteomes of Hibernating versus Normal Myocardium in Swine Models. J Proteome Res. 13(5):2571-84 (2014)

4. Tu C, Mammen MJ, Li J, Shen X, Jiang X, Hu Q, Wang J, Sethi S, Qu J*. Large-scale, ion-current-based proteomics investigation of bronchoalveolar lavage fluid in chronic obstructive pulmonary disease patients. J Proteome Res. 13(2):627-39. (2014)

5. Tu C, Sheng Q, Li J, Shen X, Zhang M, Shyr Y, Qu J*. ICan: An Optimized Ion Current-Based Quantification Procedure with Enhanced Quantitative Accuracy and Sensitivity in Biomarker Discovery. J Proteome Res.13(12):5888-97 (2014)

6. Tu C, Beharry KD, Shen X, Li J, Wang L, Aranda JV, Qu J*. Proteomic profiling of the retinas in a neonatal rat model of oxygen-induced retinopathy with a reproducible ion-current-based MS1 approach. J Proteome Res. 14(5):2109-20 (2015)

7. Kamisoglu K, Sukumaran S, Nouri-Nigjeh E, Tu C, Li J, Shen X, Duan X, Qu J, Almon RR, DuBois DC, Jusko WJ, Androulakis IP. Tandem analysis of transcriptome and proteome changes after a single dose of corticosteroid: a systems approach to liver function in pharmacogenomics. OMICS. 19(2):80-91 (2015)

8. Tu C, Beharry KD, Shen X, Li J, Wang L, Aranda JV, Qu J*. Proteomic profiling of the retinas in a neonatal rat model of oxygen-induced retinopathy with a reproducible ion-current-based MS1 approach. J Proteome Res. 14(5):2109-20 (2015)

9. Shen X, Hu Q, Li J, Wang J, Qu J*. Experimental Null Method to Guide the Development of Technical Procedures and to Control False-Positive Discovery in Quantitative Proteomics. J Proteome Res. 14(10):4147-57 (2015)

10. Tu C, Sheng Q, Li J, Ma D, Shen X, Wang X, Shyr Y, Yi Z, Qu J*. Optimization of Search Engines and Postprocessing Approaches to Maximize Peptide and Protein Identification for High-Resolution Mass Data. J Proteome Res. 14(11):4662-73 (2015)

11. Shen X, Nair B, Mahajan SD, Jiang X, Li J, Shen S, Tu C, Hsiao CB, Schwartz SA, Qu J*. New insights into the disease progression control mechanisms by comparing Long-term-non-progressors vs. Normal-progressors among HIV-1 positive patients using an ion current-based MS1 proteomics profiling.. J Proteome Res. 14(12):5225-39 (2015)

12. Shen S, Li J, Hilchey S, Shen X, Tu C, Qiu X, Ng A, Ghaemmaghami S, Wu H, Zand M, Qu J*. An Ion-Current-Based Temporal Proteomic Profiling of Influenza A Virus Infected Mouse Lungs Revealed Underlying Mechanisms of Altered Integrity of the Lung Microvascular Barrier. J Proteome Res. 15(2):540-53. (2016)

13. Qu M, An B, Shen S, Zhang M, Shen X, Duan X, Balthasar JP, Qu J*. Qualitative and quantitative characterization of protein therapeutics with liquid chromatography and mass spectrometry. Mass Spectrom Rev. [Epub ahead of print]. (2016)