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Eunice Y. Yuen, Ph.D.

Research Assistant Professor

 

State University of New York at Buffalo

Department of Physiology and Biophysics (Neuroscience Program)

Buffalo, NY 14214

Tel: (716)-829-3592

Email: yeyuen@buffalo.edu

 

 

Academic Biography:

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2008-present:  Research Assistant Professor

                        Department of Physiology and Biophysics

                        State University of New York at Buffalo

 

2006-2008:      Postdoctoral Associate                     

                        Neurodegenerative Disease Group

New York State Center of Excellence in Bioinformatics and Life Sciences

 

2003-2006:      Ph.D. in Neuroscience

                        Neuroscience Program

                        State University of New York at Buffalo

 

1998-2002:      B.S. in Rehabilitation Science (Summa Cum Laude)

                        Physical Therapy Program

                        State University of New York at Buffalo

 

2001-2002:      Undergraduate Research

                        Department of Physiology and Biophysics

                        State University of New York at Buffalo

 

2001-2002:      Clinical Fellow

                        United Cerebral Palsy Association

 

2001:               Clinical Fellow

                        Stroke Rehabilitation Clinic

Kessler Institute for Rehabilitation

 

Awards and Honors:

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2008                National Postdoctoral Association Travel Fellowship Award.

2007-09           National Alliance for Research on Schizophrenia and Depression (NARSAD) Young Investigator Award.

2006                Dean's Award for Outstanding Dissertation Research

2006                Gender Institute Research Day Presentation Award

2005                Virginia Barnes Endowment Travel Award

2004                The School of Medicine and Biomedical Sciences Dean's Travel Award

2003-06           Neuroscience Graduate Program Scholarship

2002                Interdisciplinary Graduate Program Biomedical Science Graduate Student Scholarship

2002                Summa Cum Laude Honor

2002                Golden Key Honor

1998-02           Dean's Honor List

 

Publications:

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  1. Yuen EY, Zhong P, Yan Z (2010) Homeostatic regulation of glutamatergic transmission by dopamine D4 receptors. Proc. Natl. Acad. Sci. USA. 107(51):22308-13.

 

  1. Yuen EY, Liu W, Karatsoreos IN, Ren Y, Feng J, McEwen BS, Yan Z.(2010) Mechanisms for acute stress-induced enhancement of glutamatergic transmission and working memory. Mol Psychiatry. 16(2):156-170.

 

  1. Yuen EY, Liu W, Kafri T, van Praag H, Yan Z. (2010) Regulation of AMPA Receptor Channels and Synaptic Plasticity by Cofilin Phosphatase Slingshot in Cortical Neurons. J Physiol. ;588(13):2361-71.

 

  1. Twelvetrees AE, Yuen EY, Arancibia-Carcamo IL, MacAskill AF, Rostaing P, Lumb MJ, Humbert S, Triller A, Saudou F, Yan Z, Kittler JT. (2010) Delivery of GABAARs to synapses is mediated by HAP1-KIF5 and disrupted by mutant huntingtin. Neuron. 65(1):53-65.

 

  1. Liu W, Yuen EY, Yan Z. (2010) The stress hormone corticosterone increases synaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors via serum- and glucocorticoid-inducible kinase (SGK) regulation of the GDI-Rab4 complex. J Biol Chem. 285(9):6101-8.

 

  1. Joiner ML, Lisé MF, Yuen EY, Kam AY, Zhang M, Hall DD, Malik ZA, Qian H, Chen Y, Ulrich JD, Burette AC, Weinberg RJ, Law PY, El-Husseini A, Yan Z, Hell JW. (2010) Assembly of a beta2-adrenergic receptor--GluR1 signalling complex for localized cAMP signalling. EMBO J. 29(2):482-95.

 

  1. Arancibia-Carcamo IL, Yuen EY, Muir J, Michels G, Lumb MJ, Smart T, Yan Z, Kittler J, Moss S  (2009) Ubiquitin-dependent lysosomal targeting of GABAA receptors regulates neuronal inhibition. Proc. Natl. Acad. Sci. USA. 106(41):17552-17557.

 

  1. Yuen EY, Liu W, Karatsoreoes IN, McEwen BS, Feng J, Yan Z (2009) Acute stress facilitates glutamatergic transmission and working memory in prefrontal cortex. Proc. Natl. Acad. Sci. USA 106(33):14075-14079.

 

  1. Graziane NM, Yuen EY, Yan Z (2009) Dopamine D4 receptors regulate GABAA receptor trafficking via an actin/cofilin/myosin-dependent mechanism. J. Biol. Chem., 284(13):8329-36.

 

  1. Yuen EY and Yan Z (2009) Dopamine D4 receptors regulate AMPAR trafficking and glutamatergic transmission in GABAergic interneurons of prefrontal cortex. J. Neurosci. 29:550-62

 

  1. Zhong P, Yuen EY, Yan Z (2008) Modulation of neuronal excitability by serotonin-NMDA interactions in prefrontal cortex. Mol. and Cell. Neurosci. 38:290-9.

 

  1. Yuen EY, Ren Y, Yan Z (2008) PSD-95 and calcineurin control the sensitivity of NMDA receptors to calpain cleavage in cortical neurons. Mol. Pharmacol. 74:1-11.

 

  1. Yuen EY, Jiang Q, Chen P, Feng J, Yan Z (2008) Activation of 5-HT2A/C receptors counteracts 5-HT1A regulation of NMDAR channels in pyramidal neurons of prefrontal cortex. J. Biol. Chem. 283:17194-204.

 

  1. Yuen EY, Liu W, Yan Z (2007) The phosphorylation state of GluR1 subunits determines the susceptibility of AMPA receptors to calpain cleavage. J. Biol. Chem. 282:16434-440.

 

  1. Yuen EY, Gu Z, Yan Z (2007) Calpain regulation of AMPA receptor channels in cortical pyramidal neurons. J. Physiology 580:241–254.

 

  1. Liu W, Yuen EY, Allen P, Feng J, Greengard P, Yan Z (2006) Adrenergic modulation of NMDA receptors in prefrontal cortex is differentially regulated by RGS proteins and spinophilin. Proc. Natl. Acad. Sci. USA 103: 18338-18343.

 

  1. Gu Z, Jiang Q, Yuen EY, Yan Z (2006) Activation of dopamine D4 receptors induces synaptic translocation of CaMKII in prefrontal cortical neurons. Mol Pharmacol. 69:813-22.

 

  1. Yuen EY, Jiang Q, Chen P, Gu Z, Feng J, Yan Z (2005) Serotonin 5-HT1A receptors regulate NMDA receptor channels through a microtubule-dependent mechanism. J. Neurosci. 25:5488-501.

 

  1. Yuen EY, Jiang Q, Feng J, Yan Z (2005) Microtubule regulation of NMDA receptor channels in neurons. J. Biol. Chem. 280: 29420-7.

 

  1. Wu H*, Yuen EY*, Lu Y, Matsushita M, Matsui H, Yan Z, Tomizawa K (2005) Regulation of NMDA receptors by calpain in cortical neurons. J. Biol. Chem. 280: 21588-93. *co-first author.

 

 

Book Reviews:

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1.      Yuen EY (2009). Cellular Regulation of Glutamate Receptors in Central Neurons. Published by VDM Publishing House Ltd, Mauritius, Germany.

 

  1. Yuen EY and Yan Z (2007). Serotonerigic Regulation of NMDA Receptor Trafficking and Function in Prefrontal Cortex. Monoaminergic modulation of cortical excitability; Edited by Tseng KY and Atzori M. Springer Science and Business Media, New York, USA.

 

Abstracts:

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  1. Yuen EY and Zhen Y Activity-dependent regulation of glutamatergic transmission by Dopamine D4 receptors in pyramidal neurons of prefrontal cortex (39th Annual meeting of Society for Neuroscience, Chicago, 2009).

 

  1. Yuen EY and Yan Z Acute stress enhances glutamatergic transmission and working memory in prefrontal cortex. (North East Regional Sigma Xi Conference, Ithaca, 2008; 4th Annual Celebration of Academic Excellence Symposium, Buffalo, 2008; Soc. Neurosci. Abst 2008).

 

  1. Graziane N, Yuen EY, Yan Z Dopamine D4 receptors regulate GABAA receptor trafficking via an actin/cofilin/myosin-dependent mechanism (Soc. Neurosci. Abst, 2008).

 

  1. Twelvetrees AE, Yuen EY, Arancibia-Carcamo IL, Lumb, MJ, Yan Z and Kittler J A huntingtin associated protein 1 (HAP1)/kinesin family member 5 (KIF5) trafficking complex directs transport of GABAA receptors to maintain inhibitory synaptic transmission and is inhibited by mutant hungtingtin (19th National Meeting of the British Neuroscience Association,2008).

 

  1. Graziane N, Yuen EY, Yan Z Intracellular mechanism underlying the Dopamine D4 regulation of GABAA receptor in prefrontal cortex (Soc. Neurosci. Abst, 2007).

 

  1. Yuen EY, Jiang Q, Feng J, Yan Z Opposing regulation of NMDA receptors by serotonin 5-HT1A and 5-HT2A receptors in prefrontal cortical neurons (Gordon Research Conference, 2007; Soc. Neurosci. Abst, 2007).

 

  1. Yuen EY, Yong R, Yan Z Calpain regulation of NMDAR functions and its implication in excitotoxicity. (Sigma Xi. Abst, 2007).

 

  1. Yuen EY, Gu Z, Yan Z Regulation of AMPA receptor channels by calpain in cortical neurons. (Soc. Neurosci. Abst, 2006; Sigma Xi Abst, 2006).

 

  1. Liu W, Yuen EY, Allen P, Feng J, Greengard P, Yan Z Alpha1 and alpha2 adrenergic regulation of NMDA receptor currents in prefrontal cortical neurons: distinct roles of spinophilin and RGS proteins. (Soc. Neurosci. Abst, 2006).

 

  1. Gu Z, Jiang Q, Yuen EY, Yan Z Activation of dopamine D4 receptors induces synaptic translocation of CaMKII in prefrontal cortical neurons. (Soc. Neurosci. Abst, 2005).

 

  1. Yuen EY, Jiang Q, Feng J, Yan Z Microtubule regulation of NMDA receptor channels in neurons. (Soc. Neurosci. Abst, 2005).

 

  1. Wu H, Yuen EY, Lu Y, Matsushita M, Matsui H, Yan Z, Tomizawa K Critical role of calpain in regulation of NMDA receptors in neurons. (Soc. Neurosci. Abst, 2005).

 

  1. Yuen EY, Jiang Q, Chen P, Gu Z, Feng J, Yan Serotonin 5-HT1A receptors regulate NMDA receptor channels through a microtubule-dependent mechanism in prefrontal cortical neurons. (Soc. Neurosci. Abst, 2004; Sigma Xi Abst, 2005; Gender Across Borders II Conference, 2005).

 

 

Professional Talks:

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2010    Society for Neuroscience 40th Annual Meeting, San Diego, CA.

2009    Society for Neuroscience 39th Annual Meeting, Chicago, IL.

2009    Dept. of Physiology, National University of Singapore, Singapore.

2009    Dept. of Cellular and Molecular Medicine, University of Ottawa, Canada.

2008    Society for Neuroscience 38th Annual Meeting, Washington DC.

2008    Department of Psychiatry & Behavioral Neurobiology, University of Alabama at Birmingham, AL

2008    Laboratory of Neuroscience, National Institute on Aging, John Hopkins Medical Center, Baltimore, MD.

2008    School of Medicine and Biomedical Science Postdoctoral Research Day, Buffalo, NY.

2007    School of Medicine and Biomedical Science Neuroscience Research Day, Buffalo, NY.

2007    Gordon Research Conference 75th Annual Meeting, New London, NH.

2007    Sigma Xi Research Day, Center for Tomorrow, Buffalo, NY.

2006    Society for Neuroscience 36th Annual Meeting, Atlanta, GA.

2006    Sigma Xi Research Day, Center for Tomorrow, Buffalo, NY.

2006    Gender Across Borders II Conference, Buffalo, NY.

2005    Society for Neuroscience 35th Annual Meeting, Washington, DC.

2005    Honorable symposium to Dr. Leon Farhi, Buffalo, NY.

2005    Sigma Xi Research Day, Center for Tomorrow, Buffalo, NY.

2004    Society for Neuroscience 34th Annual Meeting, San Diego, CA.

 

 

Media Coverage/Public Interest Press:

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2009    “Little Stress Helps Memory”. In: PsychCentral News.

2009    “Short Stressful Events May Improve Working Memory.” In: University at Buffalo News.

2009    “Short-term stress may benefit working memory.” In: iHealthBulletin News.

2007    “Adrenergic Receptors and RGS Modulate NMDA Receptors in Prefrontal Cortex”. In: Schizophrenia Research Forum.

2006    “New Pathway Revealed for Drugs Treating Cognitive, Mental Disorders”. In: University at Buffalo News.

2005    “Microtubules under the Microscope: Their role in mental disorders and Parkinson's disease”. In: Buffalo Physician, p 39.

2005    “Microtubules critical to mental disorders: Destruction prevents transport of receptors necessary for cognition and emotion”. In: University at Buffalo Reporter, p 6.

2005    “Microtubules May Be Linked to Mental Disorders”. In: University at Buffalo News.

2005    “Microtubules and the development of mental disorders”. In: Medical News Today.com.

2005    “Microtubules & Development of Mental Disorders: Schizophrenia Causes, Risk Factors & Prevention”. In: Schizophrenia.com.

 

Medical/Research-related Extracurricular Activities:

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2010:                           Shadowing (Gastrointestinal endoscopy; Buffalo VA Hospital; Dr. Thomas Mahl).

2010:                           Shadowing (Family Medicine; Jefferson Family Medicine Center; Dr. Vinod R. Patel).

2009:                           Shadowing (Pediatric Endocrinology; Buffalo Women & Children Hospital; Dr. John Buchlis).

2009-present:              Invited reviewer for Molecular Neurodegeneration.

2008-present:              Volunteer Science Editor at “Authorme.com”.

2008:                           Volunteer judge at Sigma Xi Research Conference (Dr. Howard Howland, Cornell University).

2007-8:                        Executive Committee of Postdotoral Scholar Association (Dr. Marilyn Morris, SUNY-UB).

                                    - helped establish postdoctoral scholar association (PDA)

                                    - organized career education program and social events for postdoctoral scholars.

                                    - organized and documented committee meeting and program.

2006:                           Volunteer (Roswell Park Cancer Research Institute fund raising event; SUNY-UB).

2006:                           Volunteer (National Multiple Sclerosis fund raising walk; SUNY-UB).

2005:                           Compound testing for antidepressants (Dr. Douglas Macdonald, Cure Huntington's Disease Initiative Inc.)

2003-4:                        Shadowing (Pediatric NeuroRehab., Room to Grow Day-Care center; Julie Stern, PT).

2002:                            Clinical Intern (Pediatric NeuroRehab., United Cerebral Palsy, Buffalo, 6 months; Julie Stern, PT).

                          Shadowing (Podiatry; Orthotics assessment and wheelchair maintenance for cerebral palsy patients).

2001-2:                        Clinical Intern; Subacute NeuroRehab., Kessler Institute for Rehabilitation, Saddle Brook, NJ.

                        Shadowing (Physiatrist; Amputee clinic at Kessler Institute for Rehabilitation).

                        Shadowing (Neurologist; Kessler Institute Dept. of Neurology, Saddle Brook, NJ; Shailesh S. Parikh, MD).

2001-2:                        Clinical Intern (Subacute Cardiac and Orthopedic Rehab., St., James Mercy Hospital, Hornell, NY).

                                    Shadowing (Orthopedic Surgeon; observe a total hip replacement surgical procedure; John Halpenny, MD).

2000-1:                        Clinical Intern (Orthopedic Medicine, Pro-Care Physical Therapy Clinic, Cortland, NY; Jill Barden, DPT).

2000:                           Shadowing (Emergency Room, Buffalo VA Hospital, Buffalo, NY).

2000:                           Shadowing (ENT, Buffalo VA Hospital, Buffalo, NY).

1998-9:                        Volunteer (Physical Therapy and Occupational Therapy, Buffalo VA Hospital).

 

Teaching Experience:

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2006-present:              Lectured and supervised MD/Ph.D. fellows involving electrophysiology principle and technique.

2007-8:                        Postdoctoral fellows teaching certificate program “Teaching Skills at the College/University Setting”

2007-8:                        Consultant of neuronal culture preparation for visiting clinical fellows (The Women and Children Hospital, NY) and industry scientists (Invitrogen, MD).

2001:                           Teaching Assistant: lectured in Neuroanatomy Laboratory for health professional students.

2001:                           Teaching Assistant: lectured and carried out review sections in Gross Anatomy Laboratory for health professional students.

1998-present:              Volunteer tutor for chronically sick children. (Hong Kong St. Mary Catholic Hospital, summer).

 

Research Skills:

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Electrophysiology; neuroanatomical dissection; primary neuronal culture; immunochemistry; confocal microscopy; pharmacological intervention; western blot (gel electrophoresis, biotinylation, co-immunoprecipitation); protein assay; RT-PCR (single cell); transfection (Lipofectamine 2000); DNA amplification and purification; behavioral testing for various cognitive functions; animal surgery and microinjection for drug delivery.

 

 

Professional Society:

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Society for Neuroscience

The New York Academy of Sciences

Sigma Xi, The Scientific Research Society

International Writing Community at Authorme.com

National Postdoctoral Association

 

 

 

Updated on 1/2011