Studying molecular mechanisms of transcription factor mediated pathways and to discover small molecules that target specific transcription factor conformation. Design, synthesis and evaluation of inducers, substrates and inhibitors of drug metabolizing enzymes. We explore new chemical space by employing state-of-the-art Omics guided structure determination techniques to probe protein interactome and discover new drugs against a variety of diseases including diabetes and cancer.
Isokpehi RD, Rajnarayanan RV, Jeffries CD, Oyeleye TO, Cohly HH, Rajnarayanan R; Integrative sequence and tissue expression profiling of chicken and mammalian aquaporins.; BMC Genomics; 2009 Jul; 10 Su; 7-7
Hari HP Cohly, Raphael D. Isokpehi and Rajendram V. Rajnarayanan. (2008) Compartmentalization of Aquaporins in the human intestine. Int J Environ Res Public Health; 5 (2):115-120.
Narayanan Rajendran, Rajendram V. Rajnarayanan and Donald R. Demuth (2008) Molecular phylogenetic analysis of tryptophanyl-tRNA synthetase of Actinobacillus actinomycetemcomitans. Journal of Biological Sciences C. 63 (5-6):418-28.
Veena Menon, Dongmei Li, Neeraj Chauhan, Rajendram Rajnarayanan, and Richard Calderone. 2006. Functional studies of the Ssk1p response regulator protein of Candida albicans as determined in receiver domain point mutants. Mol Microbiol. 62(4):997-1013.
Sivanesan, D., Rajnarayanan, R. V., Doherty, J., and Pattabiraman, N. 2005. In-silico screening using flexible ligand binding pocket: A molecular dynamics-based approach. J Comp Aided Mol Design. 19(4):213-28.
Addanki P. Kumar, Gretchen E. Garcia, Rita Gosh, Rajendram V Rajnarayanan, William Alworth and Thomas Slaga. 2004. Curcumin derivatives: Potential for prostate cancer management: Toxicol Pathol; 32: 161-163.
Rajnarayanan, R. V., and Wang, K. 2004. Ion-pair assisted recovery of MALDI mass spectral signals from SDS containing peptides/proteins. J Mass Spectrom. 39 (1), 79-85.
Rajnarayanan, R. V., Sivanesan, D., and Pattabiraman, N. 2004. “Teaching old drug to kill new bugs”:Structure-based design of anti-SARS drugs. Biochem. Biophys. Res. Commun. 321 (2), 370-378.
Kumar, A. P., Garcia, G. E., Adamian, A., Rajnarayanan, R. V., Alworth, W. L., and Slaga T. J. (2003) 4-hydroxy-3-methoxybenzoic acid methyl ester (HMBME): a Curcumin derivative targets Akt/NFkappaB cell survival signaling pathway: potential for prostate cancer management. Neoplasia. 5(3), 255-266.
Rowley, C. W., Rajnarayanan, R. V., Hopkins, N. E., and Alworth. W. L. (2003) Differential expression of cyp102 gene constructs in Bacillus megaterium by estradiol and 4-sec- butylphenol. Biochem. Biophys. Res.Commun. 300, 102-106.
Rajnarayanan, R. V., Rowley, C. W., Hopkins, N. E., and Alworth. 2001. W. L. Regulation of phenobarbitalmediated induction of CYP102 (cytochrome P450 BM3) in Bacillus megaterium by phytochemicals from soy and green tea. J. Agri. Food. Chem. 49(10); 4930-4936.
Addanki P. Kumar, Gretchen E. Garcia, Rajendram Rajnarayanan, William L. Alworth and Thomas L. Slaga. 2001. Development of Novel Apoptotic Inducers for Prostate Cancer Therapy. Pro Am Assoc Can Res. 42.
Kent, U. M., Mills, D. E., Rajnarayanan, R. V., Alworth, W. L., and Hollenberg, P. F. 2002. Effect of 17-alpha-ethynylestradiol on the activities of P450 2B enzymes: characterization of inactivation of P450s 2B1 and 2B6 and identification of metabolites. J. Pharm. Exp. Therap. 300 (2); 549-558.
Nikov, G. N., Eshete, M., Rajnarayanan, R. V., and Alworth. 2001. W. L. Interactions of synthetic estrogens with human estrogen receptors. J. Endocrinology. 170(1), 137-145.