Material for courses offered by G.
Koudelka
(always under construction)
Undergraduate Courses:
Fundamentals of Biological Chemistry (Bio 205)
Schedule
Advanced Molecular Biology I (Bio 401)
Problem Sets/Supplemental Materials
Graduate Courses
Advanced Molecular Biology I (Bio 501)
Problem Sets/Supplemental Materials
Advanced Molecular Biology (Bio 504)
DNA Repair Material
DNA Repair
Slides (.ppt)
Prokaryotic Transcription
Overview
of transcription (.pdf)-Print & bring to
class!
Review articles (read for 30 January)
Core
RNA polymerase
RNA
Polymerase Holoenzyme + DNA
Promoter structure & recognition
Read for 30 January & 1 February
Selection of -10 sequences
-10 Recognition by sigma
Initiation of transcription
Read for 1 & 3 February
Up elements-a
new promoter feature
Promoter
sequence & abortive initiation
Characterization
of closed & open promoter complexes
Regulation of initiation (activation)
Read for 6 February
Activation
of transcription by lambda repressor (lecture notes)
Region 4 of sigma70 as a target for transcription regulation (review) go to page then click on the .pdf link
Stalled elongation complexes & their resolution (insights into new classes of antibiotics)
Read for 8 February
Bacterial transcription elongation factors: new insights into molecular mechanism of action (review) (pdf link at top of page)
Lambda Lecture
Material
(2005)
February 28
Lambda Lifestyles
Review
article (read only pages 193-202)
Lambda
life cycle summmary (Bring to class)
Lecture
notes (.ppt)(Bring
to class)
March 2
Activation of transcription by cI
Lecture
Notes (.ppt-Bring to class)
Hawley&McClure
Kuldell&Hochschild
Jain, et al. FYI only! (link is accessible
only from .buffalo.edu IP addresses)
March 4
Long distance cooperativity in gene regulation
Dodd et al.
2001
Dodd et al. 2004
Chemistry 412-Biochemistry
Lecture 1 (ppt)
Lecture
2&3 (ppt)
Lecture 4 (ppt)
Site-directed
mutagenesis papers
Protein nucleic acid interactions (Bio/Mic 522)
Course page
Schedule
Topics in Macromolecular Structure (Bio 608)