Publications

All of the listed articles and patents are available on the appropriate
publishers' websites.

Peer-reviewed Journal Articles

M. B. Deci, S. W. Ferguson, M. Liu, D. C. Peterson, S. P. Koduvayur, J. Nguyen*. Utilizing clathrin triskelions as carriers for spatially controlled multi-protein display. Biomaterials. August 2016. http://dx.doi.org/10.1016/j.biomaterials.2016.08.044

S.W. Ferguson, J. Nguyen*. Exosomes as therapeutics: The implications of molecular composition and exosomal heterogeneity. Journal of Controlled Release. 2016.

J. Nguyen, J.R. Cooke, J.A. Ellis, M. Deci, C.W. Emala, J.N. Bruce, I.J. Bigio, R.M. Straubinger, S. Joshi. Cationizable lipid micelles as vehicles for intraarterial glioma treatment. J Neurooncol. 2016.

S. Heck, J. Nguyen, D.D. Le, R. Bals, Q.T. Dinh. Pharmacological Therapy of Bronchial Asthma: The Role of Biologicals. Int Arch Allergy Immunol. 2016; 168(4).

A.J. Omlor, J. Nguyen, R. Bals, Q.T. Dinh. Nanotechnology in respiratory medicine. Respir Res. 2015; 16.

J. Nguyen*, R. Sievers, J.P. Motion, S. Kivimae, Q. Fang, R.J. Lee*. Delivery of lipid micelles into infarcted myocardium using a lipid-linked matrix-metalloproteinase targeting peptide. Molecular Pharmaceutics. Feb. 2015
* Co-Corresponding Authors

C. Valentine, H. Zhang, P. Phuan, J. Nguyen, A. Verkman, P. Haggie. Small molecule screen yields inhibitors of pseudomonas homoserine lactone-induced host responses. Cell Microbiol. 2013 Aug 2. doi:10.1111/cmi.12176.

C. Walsh, J. Nguyen, M. Tiffany and F. Szoka. Synthesis, characterization and evaluation of ionizable lysine-based lipids for siRNA delivery. Bioconjugate Chemistry. Nov. 2012

M. Motion, J. Nguyen and F. Szoka. Phosphatase-triggered fusogenic liposomes for cytoplasmic delivery of cell-impermeable compounds. Angewandte Chemie International Edition. June 2012.
Selected as a "Hot Paper" by the Editors for its importance in a rapidly evolving field of interest.

R. Reul, J. Nguyen, A. Biela, E. Marxer, U. Bakowsky, G. Klebe, T. Kissel. Non-toxic, biodegradable amine-modified hyperbranched polyester: Biophysical and biological investigation of DNA nano-complexes in vitro. International Journal of Pharmaceutics. 2012 Jul 17; 436 (1-2): 97-105.

J. Nguyen, C. Walsh, J.P. Motion, E. Perttu, F. Szoka. Controlled nucleation of lipid nanoparticles. Pharmaceutical Research. 2012 Aug; 29 (8): 2236-48.

C. Walsh, J. Nguyen and F. Szoka. Synthesis and characterization of novel zwitterionic lipids with pH-responsive biophysical properties. Chem Comm (Camb). 2012 Jun 7; 48 (45): 5575-7

J. Nguyen and F. Szoka. Nucleic acid delivery: the missing pieces of the puzzle. Accounts of Chemical Research. 2012 Jul 17; 45(7): 1153-62.
One of the journal's 20 most downloaded articles in March 2012

J. Nguyen, R. Reul, S. Roesler, E. Dayyoub, T. Schmehl, T. Gessler, W. Seeger and T. Kissel. Amine-modified poly(vinyl alcohol)s as non-viral vectors for siRNA delivery: Effects of the degree of amine substitution on physicochemical properties and knockdown efficiency. Pharmaceutical Research. 2010 Dec; 27 (12): 2670-82

M. Beck-Broichsitter, M. Thieme, J. Nguyen, T. Schmehl, T. Gessler, W. Seeger, T. Kissel, A. Greiner. Novel “nano in nano” composites for controlled drug delivery: Biodegradable nanoparticles encapsulated into nanofiber nonwovens. Macromolecular Bioscience. 2010 Dec 8;10(12):1527-35

J. Nguyen, R. Reul, T. Betz, E. Dayyoub, T. Schmehl, T. Gessler, U. Bakowsky, W. Seeger and T. Kissel. Nanocomposites of lung surfactant and biodegradable cationic nanoparticles improve transfection efficiency to lung cells. Journal of Controlled Release. 2009 Nov 16;140(1):47-54

R. Reul, J. Nguyen, T. Kissel. Amine-modified hyperbranched polyesters as non-toxic, biodegradable gene delivery systems. Biomaterials. 2009 Oct;30(29):5815-24

Y. Liu, J. Nguyen, T. Steele, O. Merkel, T. Kissel. A new synthesis method and degradation of hyper-branched polyethylenimine grafted polycaprolactone block mono-methoxyl poly (ethylene glycol) copolymers (hy-PEI-g-PCL-b-mPEG) as potential DNA delivery vectors. Polymer. 2009, 50 (16), 3895-3904

J. Nguyen, T. Steele, O. Merkel, R. Reul, T. Kissel. Fast degrading polyesters as siRNA nano-carriers for plumonary gene therapy. Journal of Controlled Release. 2008 Dec 18; 132(3): 243-51

J. Nguyen, X. Xie, M. Neu, R. Dumitrascu, R. Reul, R. Schermuly, L. Fink, T. Schmehl, T. Gessler, W. Seeger and T. Kissel. Effects of cell-penetrating peptides and pegylation on transfection efficiency of polyethylenimine in mouse lungs. Journal of Gene Medicine. 2008 Nov;10(11):1236-46.

E. Rytting, J. Nguyen, X. Wang and T. Kissel. Biodegradable polymeric nanocarriers for pulmonary drug delivery. Expert Opinion on Drug Delivery. 2008 Jun;5(6):629-639

Patents

S. Ferguson and J. Nguyen.* Compositions and methods for programming extracellular vesicles. Filed 2016 Apr, US patent application No. 62/326,093

T. Schmehl, J. Nguyen, M. Beck-Broichsitter, T. Gessler, M. Thieme, T. Kissel, (WO/2010/106063). Composite Materials Loaded with Therapeutic and Diagnostic Agents Comprising Polymer Nanoparticles and Polymer Fibers

F. Szoka, C. Walsh, V. Venditto, J. Nguyen, E. Perttu: Zwitterionic lipids. The Regents of the University of California Feb, 23 2012 (WO 2012/024233)