Publications

All of the listed articles and patents are available on the appropriate
publishers' websites.

Note that in the below * indicated corresponding author.

Peer-reviewed Journal Articles

M. Deci, M. Liu, QT. Dinh, J. Nguyen*. Precision engineering of targeted nanocarriers, WIREs Nanomedicine and Nanobiotechnology, Accepted, January 2018

S. W. Ferguson, J. Wang, C. J. Lee, M. Liu, S. Neelamegham, J. M. Canty, J. Nguyen*. The microRNA regulatory landscape of MSC-derived exosomes: a systems view. Scientific reports. 2018 January, http://rdcu.be/FmZn

J. Nguyen, SS. Hossain, JRN Cooke, JA Ellis, MB Deci, CW Emala, JN Bruce, IJ Bigio, RM Straubinger, S. Joshi. Flow arrest intra-arterial delivery of small TAT-decorated and neutral micelles to gliomas. J Neurooncol. 2017 May;133(1):77-85. doi: 10.1007/s11060-017-2429-5.

Omlor, R. Bals, J. Nguyen, QT. Dinh. Local Effects on Airway Inflammation and Systemic Uptake of 5 nm PEGylated and Citrated Gold Nanoparticles in Asthmatic Mice. Small, 2017 Mar;13(10). doi: 10.1002/smll.201603070.

M. B. Deci, S. W. Ferguson, M. Liu, D. C. Peterson, S. P. Koduvayur, J. Nguyen*. Utilizing clathrin triskelions as carriers for spatially controlled multi-protein display. Biomaterials. August 2016. http://dx.doi.org/10.1016/j.biomaterials.2016.08.044

S.W. Ferguson, J. Nguyen*. Exosomes as therapeutics: The implications of molecular composition and exosomal heterogeneity. Journal of Controlled Release. 2016 Apr 28;228:179-190. doi: 10.1016/j.jconrel.2016.02.037. https://www.sciencedirect.com/science/article/pii/S0168365916301006?via%3Dihub

J. Nguyen, J.R. Cooke, J.A. Ellis, M. Deci, C.W. Emala, J.N. Bruce, I.J. Bigio, R.M. Straubinger, S. Joshi. Cationizable lipid micelles as vehicles for intraarterial glioma treatment. J Neurooncol. 2016.

S. Heck, J. Nguyen, D.D. Le, R. Bals, Q.T. Dinh. Pharmacological Therapy of Bronchial Asthma: The Role of Biologicals. Int Arch Allergy Immunol. 2016; 168(4).

A.J. Omlor, J. Nguyen, R. Bals, Q.T. Dinh. Nanotechnology in respiratory medicine. Respir Res. 2015; 16.

J. Nguyen*, R. Sievers, J.P. Motion, S. Kivimae, Q. Fang, R.J. Lee*. Delivery of lipid micelles into infarcted myocardium using a lipid-linked matrix-metalloproteinase targeting peptide. Molecular Pharmaceutics. Feb. 2015
* Co-Corresponding Authors

C. Valentine, H. Zhang, P. Phuan, J. Nguyen, A. Verkman, P. Haggie. Small molecule screen yields inhibitors of pseudomonas homoserine lactone-induced host responses. Cell Microbiol. 2013 Aug 2. doi:10.1111/cmi.12176.

C. Walsh, J. Nguyen, M. Tiffany and F. Szoka. Synthesis, characterization and evaluation of ionizable lysine-based lipids for siRNA delivery. Bioconjugate Chemistry. Nov. 2012

M. Motion, J. Nguyen and F. Szoka. Phosphatase-triggered fusogenic liposomes for cytoplasmic delivery of cell-impermeable compounds. Angewandte Chemie International Edition. June 2012.
Selected as a "Hot Paper" by the Editors for its importance in a rapidly evolving field of interest.

R. Reul, J. Nguyen, A. Biela, E. Marxer, U. Bakowsky, G. Klebe, T. Kissel. Non-toxic, biodegradable amine-modified hyperbranched polyester: Biophysical and biological investigation of DNA nano-complexes in vitro. International Journal of Pharmaceutics. 2012 Jul 17; 436 (1-2): 97-105.

J. Nguyen, C. Walsh, J.P. Motion, E. Perttu, F. Szoka. Controlled nucleation of lipid nanoparticles. Pharmaceutical Research. 2012 Aug; 29 (8): 2236-48.

C. Walsh, J. Nguyen and F. Szoka. Synthesis and characterization of novel zwitterionic lipids with pH-responsive biophysical properties. Chem Comm (Camb). 2012 Jun 7; 48 (45): 5575-7

J. Nguyen and F. Szoka. Nucleic acid delivery: the missing pieces of the puzzle. Accounts of Chemical Research. 2012 Jul 17; 45(7): 1153-62.
One of the journal's 20 most downloaded articles in March 2012

J. Nguyen, R. Reul, S. Roesler, E. Dayyoub, T. Schmehl, T. Gessler, W. Seeger and T. Kissel. Amine-modified poly(vinyl alcohol)s as non-viral vectors for siRNA delivery: Effects of the degree of amine substitution on physicochemical properties and knockdown efficiency. Pharmaceutical Research. 2010 Dec; 27 (12): 2670-82

M. Beck-Broichsitter, M. Thieme, J. Nguyen, T. Schmehl, T. Gessler, W. Seeger, T. Kissel, A. Greiner. Novel “nano in nano” composites for controlled drug delivery: Biodegradable nanoparticles encapsulated into nanofiber nonwovens. Macromolecular Bioscience. 2010 Dec 8;10(12):1527-35

J. Nguyen, R. Reul, T. Betz, E. Dayyoub, T. Schmehl, T. Gessler, U. Bakowsky, W. Seeger and T. Kissel. Nanocomposites of lung surfactant and biodegradable cationic nanoparticles improve transfection efficiency to lung cells. Journal of Controlled Release. 2009 Nov 16;140(1):47-54

R. Reul, J. Nguyen, T. Kissel. Amine-modified hyperbranched polyesters as non-toxic, biodegradable gene delivery systems. Biomaterials. 2009 Oct;30(29):5815-24

Y. Liu, J. Nguyen, T. Steele, O. Merkel, T. Kissel. A new synthesis method and degradation of hyper-branched polyethylenimine grafted polycaprolactone block mono-methoxyl poly (ethylene glycol) copolymers (hy-PEI-g-PCL-b-mPEG) as potential DNA delivery vectors. Polymer. 2009, 50 (16), 3895-3904

J. Nguyen, T. Steele, O. Merkel, R. Reul, T. Kissel. Fast degrading polyesters as siRNA nano-carriers for plumonary gene therapy. Journal of Controlled Release. 2008 Dec 18; 132(3): 243-51

J. Nguyen, X. Xie, M. Neu, R. Dumitrascu, R. Reul, R. Schermuly, L. Fink, T. Schmehl, T. Gessler, W. Seeger and T. Kissel. Effects of cell-penetrating peptides and pegylation on transfection efficiency of polyethylenimine in mouse lungs. Journal of Gene Medicine. 2008 Nov;10(11):1236-46.

E. Rytting, J. Nguyen, X. Wang and T. Kissel. Biodegradable polymeric nanocarriers for pulmonary drug delivery. Expert Opinion on Drug Delivery. 2008 Jun;5(6):629-639

Book Chapters

S. Ferguson, J. Megna, J. Nguyen*. Composition, physicochemical and biological properties of exosomes secreted from cancer cells. Invited Book Chapter (accepted, anticipated publication date of book is March 2018)

Patents

S. Ferguson and J. Nguyen.* Compositions and methods for programming extracellular vesicles. Filed 2016 Apr, US patent application No. 62/326,093

T. Schmehl, J. Nguyen, M. Beck-Broichsitter, T. Gessler, M. Thieme, T. Kissel, (WO/2010/106063). Composite Materials Loaded with Therapeutic and Diagnostic Agents Comprising Polymer Nanoparticles and Polymer Fibers

F. Szoka, C. Walsh, V. Venditto, J. Nguyen, E. Perttu: Zwitterionic lipids. The Regents of the University of California Feb, 23 2012 (WO 2012/024233)