Peer-reviewed publications:

 

(1)   Hu Z, Li H, Jiang H, Ren Y, Yu X, Qiu J, Stablewski AB, Zhang B, Buck MJ, Feng J (2020). Transient Inhibition of mTOR in Human Pluripotent Stem Cells Enables Robust Formation of Mouse-Human Chimeric Embryos. Science Advances 6: eaaz0298

(2)   Lin L, Liu A, Li HQ, Feng J, Yan Z (2019) Inhibition of histone methyltransferases EHMT1/2 reverses b amyloid-induced loss of AMPAR currents in human stem cell-derived cortical neurons. J. Alzheimer's Disease 70:1175-1185

(3)   Li H, Jiang H, Yin X, Bard JE, Zhang B, Feng J (2019). Attenuation of PRRX2 and HEY2 enables efficient conversion of adult human skin fibroblasts to neurons. Biochem Biophys Res Commun. 516:765-769.

(4)   H Li, H Jiang, B Zhang, J Feng (2018). Modeling Parkinson’s Disease Using Patient-specific Induced Pluripotent Stem Cells. Journal of Parkinson’s Disease, 8:479–493

(5)   P Zhong, Z Hu, H Jiang, Z Yan, J Feng (2017). Dopamine Induces Oscillatory Activities in Human Midbrain Neurons with Parkin Mutations. Cell Reports 19:1033-1044     

(6)    Z Xu, X Chu, H Jiang, H Schilling, S Chen, J Feng (2017). Induced dopaminergic neurons: A new  promise for Parkinson's disease. Redox Biology 11:606-612.

(7)        J Feng (2016). Kinetic Barriers in Transdifferentiation. Cell Cycle, 15:1019-1020

(8)        Z Xu, H Jiang, P Zhong, Z Yan, S Chen, J Feng (2016). Direct Conversion of Human Fibroblasts to Induced Serotonergic Neurons. Molecular Psychiatry, 21:62-70.

(9)        H Jiang, Z Xu, P Zhong, Y Ren, G Liang, HA Schilling, Z Hu, Y Zhang, X Wang, S Chen, Z Yan, J Feng (2015). Cell Cycle and p53 Gate the Direct Conversion of Human Fibroblasts to Dopaminergic Neurons. Nature Communications, 6: 10100.

(10)     Z Hu, J Pu, H Jiang, P Zhong, J Qiu, F Li, X Wang, B Zhang, Z Yan, J Feng (2015). Generation of Naivetropic Induced Pluripotent Stem Cells from Parkinson’s Disease Patients for High Efficiency Genetic Manipulation and Disease Modeling. Stem Cells and Development. 24:2591-2604

(11)     J Pu, D Frescas, B Zhang, J Feng (2015). Utilization of TALEN and CRISPR/Cas9 technologies for gene targeting and modification. Exp. Biol. Med. 240:1065-1070

(12)     Y Ren, H Jiang, Z Hu, K Fan, J Wang, S Janoschka, X Wang, S Ge, J Feng (2015). Parkin Mutations Reduce the Complexity of Neuronal Processes in iPSC-derived Human Neurons. Stem Cells, 33:68-78.

(13)     A Pliss, AN Kuzmin, AV Kachynski, H Jiang, Z Hu, Y Ren, J Feng, PN Prasad (2013). Nucleolar Molecular Signature of Pluripotent Stem Cells. Anal. Chem., 85:3545-3552

(14)     H Jiang, Y Ren, EY Yuen, P Zhong, M Ghaedi, Z Hu, G Azabdaftari, K Nakaso, Z Yan, J Feng (2012). Parkin Controls Dopamine Utilization in Human Midbrain Dopaminergic Neurons Derived from Induced Pluripotent Stem Cells. Nature Communications, 3:668. DOI 10.1038/ncomms1669.

(15)     O. Cooper, H. Seo, S. Andrabi, C. Guardia-Laguarta, J. Graziotto, M. Sundberg, J. R. McLean, L. Carrillo-Reid, Z. Xie, T. Osborn, G. Hargus, M. Deleidi, T. Lawson, H. Bogetofte, E. Perez-Torres, L. Clark, C. Moskowitz, J. Mazzulli, L. Chen, L. Volpicelli-Daley, N. Romero, H. Jiang, R. J. Uitti, Z. Huang, G. Opala, L. A. Scarffe, V. L. Dawson, C. Klein, J. Feng, O. A. Ross, J. Q. Trojanowski, V. M. Lee, K. Marder, D. J. Surmeier, Z. K. Wszolek, S. Przedborski, D. Krainc, T. M. Dawson, O. Isacson (2012). Pharmacological Rescue of Mitochondrial Deficits in iPSC-Derived Neural Cells from Patients with Familial Parkinson’s Disease. Science Translational Medicine 4, 141ra90.

(16)     J Feng (2012). The role of parkin in Parkinson’s disease: a stem cell perspective. Neurodegenerative Disease Management, 2:239-241 

(17)     J Pu, H Jiang, B Zhang, J Feng (2012). Redefining Parkinson's disease research using induced pluripotent stem cells. Current Neurology and Neuroscience Reports. 12:392-398.

(18)     MD Garrick, L Zhao, JA Roth, H Jiang, J Feng, NJ Foot, H Dalton, S Kumar, LM Garrick (2012). Isoform specific regulation of divalent metal (ion) transporter (DMT1) by proteasomal degradation. BioMetals, 25:787-793.

(19)     JB Lee, J Wei, W Liu, J Cheng, J Feng, Z Yan (2012). Histone Deacetylase 6 Gates the Synaptic Action of Acute Stress in Prefrontal Cortex. J. Physiol. 590:1535-1546

(20)     Y. Ren, X. Liu, S. Lesage, M. Cai, J. Pu, B. Zhang, A. Brice, J. Feng (2012). The Normal Parkin Sequence. Movement Disorders 27:463-464.

(21)     DJ Klionsky, FC Abdalla, ... J Feng, … Zuckerbraun B (2012). Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 8:445-544. (over 100 authors in alphabetical order except the corresponding author).

(22)     S. M Choi, H. Liu, P. Chaudhari, Y. Kim, L. Cheng, J. Feng, S. Sharkis, Z. Ye and Y-Y Jang (2011) Reprogramming of EBV-immortalized B-lymphocyte cell lines into induced pluripotent stem cells. Blood 118:1801-1805.

(23)     Y. Ren, H. Jiang, D. Ma, K. Nakaso, J. Feng (2011). Parkin Degrades Estrogen Related Receptors to Limit the Expression of Monoamine Oxidases. Hum. Mol. Genet. 20:1074-1083.

(24)     E.Y. Yuen, W. Liu, I.N. Karatsoreos, Y. Ren, J. Feng, B.S. McEwen, Z. Yan. (2011) Mechanisms for acute stress-induced enhancement of glutamatergic transmission and working memory. Mol Psychiatry. 16:156-170

(25)     W. Liu, F. Dou, J. Feng, Z. Yan (2011) RACK1 is involved in b-amyloid impairment of muscarinic regulation of GABAergic transmission. Neurobiol. Aging 32:1818-26.

(26)     B. Porton, R.M. Rodriguiz, L.E. Phillips, J.W. Gilbert, J. Feng, P. Greengard, H.T. Kao, W.C. Wetsel (2010) Mice lacking synapsin III show abnormalities in explicit memory and conditioned fear. Genes Brain Behav. 9:257-268.

(27)     H. Jiang, D. Cheng, W. Liu, J. Peng, J. Feng (2010). Protein Kinase C Inhibits Autophagy and Phosphorylates LC3. Biochem Biophys Res Commun. 395:471-476.

(28)     J.A. Roth, S. Singleton, J. Feng, M. Garrick, P.N. Paradkar (2010) Parkin regulates metal transport via proteasomal degradation of the 1B isoforms of divalent metal transporter 1 (DMT1). J. Neurochem. 113:454-64.

(29)     Y. Ren, H. Jiang, F. Yang, K. Nakaso, and J. Feng (2009). Parkin protects dopaminergic neurons against microtubule-depolymerizing toxins by attenuating MAP kinase activation. J. Biol. Chem. 284:4009-4017

(30)     E.Y. Yuen, W. Liu, I.N. Karatsoreos, J. Feng, B.S. McEwen, and Z. Yan (2009). Acute Stress Enhances Glutamatergic Transmission in Prefrontal Cortex and Facilitates Working Memory. Proc. Nat. Acad. Sci. 106:14075-14079.

(31)     Q. Jiang, Y. Ren, and J. Feng (2008). Direct Binding with Histone Deacetylase 6 Mediates the Reversible Recruitment of Parkin to the Centrosome. J. Neurosci. 28:12993–13002.

(32)     M.M. Madden, W. Song, P.G. Martell, Y. Ren, J. Feng, and Q. Lin (2008). Substrate Properties of Ubiquitin Carboxyl-Terminally Derived Peptide Probes for Protein Ubiquitination. Biochem. 47:3636-3644.

(33)     E.Y. Yuen, Q. Jiang, P. Chen, J. Feng, Z. Yan (2008). Activation of 5-HT2A/C Receptors Counteracts 5-HT1A Regulation of NMDAR Channels in Pyramidal Neurons of Prefrontal Cortex. J. Biol. Chem. 283:17194-17204.

(34)     H.-T. Kao, P. Li, H.M. Chao, S. Janoschka, K. Pham,  J. Feng, B.S. McEwen, P. Greengard, V.A. Pieribone, and B. Porton (2008). Early involvement of synapsin III in neural progenitor cell development in the adult hippocampus. J. Comp. Neurol. 507:1860-1870.

(35)     G. Chen, P. Chen, H. Tan, D. Ma, F. Dou, J. Feng, Z. Yan (2008) Regulation of the NMDA receptor-mediated synaptic response by acetylcholinesterase inhibitors and its impairment in an animal model of Alzheimer’s disease. Neurobiol. Aging 29:1795-1804.

(36)     Y. Ren and J. Feng (2007) Rotenone Selectively Kills Serotonergic Neurons through a Microtubule-dependent Mechanism. J. Neurochem. 103:303-311.

(37)     J. Feng (2006). Microtubule: a Common Target for Parkin and Parkinson’s Disease Toxins. Neuroscientist. 12:469-476.

(38)     W. Liu, E. Y. Yuen, P.B. Allen, J. Feng, P. Greengard, and Z. Yan (2006). Adrenergic modulation of NMDA receptors in prefrontal cortex is differentially regulated by RGS proteins and spinophilin. Proc. Nat. Acad. Sci. 103:18338-18343.

(39)     Q. Jiang, Z. Yan, and J. Feng (2006). Neurotrophic factors stabilize microtubules and protect against rotenone toxicity on dopaminergic neurons. J. Biol. Chem. 281:29391-29400.

(40)     Q. Jiang, Z. Yan, and J. Feng (2006). Activation of Group III Metabotropic Glutamate Receptors Attenuates Rotenone Toxicity on Dopaminergic Neurons through a Microtubule-dependent Mechanism. J. Neurosci. 26:4318-4328.

(41)     H. Jiang, Q. Jiang, W. Liu and J. Feng (2006). Parkin Suppresses the Expression of Monoamine Oxidases. J. Biol. Chem. 281:8591-8599.

(42)     P.B. Allen, V. Zachariou, P. Svenningsson, A.C. Lepore, D. Centonze, C. Costa, S. Rossi, G. Bender, G. Chen, J. Feng, G.L. Snyder, G. Bernardi, E.J. Nestler, Z. Yan, P. Calabresi, P. Greengard (2006). Distinct roles for spinophilin and neurabin in dopamine-mediated plasticity. Neurosci. 140:897-911

(43)     X. Wang, Z. Gu, P. Zhong, G. Chen, J. Feng, and Z. Yan (2006). Aberrant regulation of NMDAR functions by dopamine D4 receptors in rats after phencyclidine exposure. Mol. Cell. Neurosci. 31:15-25.

(44)     Y. Ren, W. Liu, H. Jiang, Q. Jiang, and J. Feng (2005). Selective Vulnerability of Dopaminergic Neurons to Microtubule Depolymerization. J. Biol. Chem. 280:34105-34112.

(45)     F. Yang, Q. Jiang, J. Zhao, Y. Ren, M.D. Sutton and J. Feng (2005). Parkin Stabilizes Microtubules through Strong Binding Mediated by Three Independent Domains. J. Biol. Chem. 280:17154-17162.

(46)     E.Y. Yuen, Q. Jiang, J. Feng, and Z. Yan (2005). Microtubule regulation of NMDA receptor channels in neurons. J. Biol. Chem. 280:29420-29427.

(47)     E.Y. Yuen, Q. Jiang, P. Chen, Z. Gu, J. Feng and Z. Yan (2005). Serotonin 5-HT1A receptors regulate NMDA receptor channels through a microtubule-dependent mechanism. J. Neurosci. 25:5488-5501.

(48)     H. Jiang, Q. Jiang and J. Feng (2004). Parkin Increases Dopamine Uptake by Enhancing the Cell Surface Expression of Dopamine Transporter. J. Biol. Chem. 279:54380-54386.

(49)     H. Jiang, Y. Ren, J. Zhao and J. Feng (2004). Parkin protects human dopaminergic neuroblastoma cells against dopamine-induced apoptosis.  Hum. Mol. Genet. 13: 1745-1754.

(50)     Z. Yan and J. Feng (2004). Alzheimer’s disease: interactions between cholinergic functions and b-amyloid. Curr. Alz. Res.  1:241-248 (review).

(51)     Q. Wang, J. Zhao, A.E. Brady, J. Feng, P.B. Allen, R.J. Lefkowitz, P. Greengard, and L.E. Limbird (2004). Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors.  Science 304: 1940-1944.

(52)     D. Gitler, Y. Takagishi, J. Feng, Y. Ren, R. Rodriguiz, W. Wetsel, P. Greengard and G. J. Augustine (2004). Different presynaptic roles of synapsins at excitatory and inhibitory synapses. J. Neurosci. 24:11368 –11380.

(53)     D. Gitler, Y. Xu, H.-T. Kao, D. Lin, S. Lim, J. Feng, P. Greengard and G.J. Augustine (2004). Molecular determinants of synapsin targeting to presynaptic terminals. J. Neurosci. 24: 3711-3720.

(54)     T. Matsuda, J. Feng, B.A. Witthuhn, Y. Sekine and J.N. Ihle (2004). Determination of the transphosphorylation sites of Jak2 kinase. Biochem. Biophys. Res. Commun. 325:586-594.

(55)     J. Feng (2003). Genetic factors in Parkinson’s disease and potential therapeutic targets. Curr. Neuropharmacol. 1: 301-313 (review).

(56)     J. Zhao, Y. Ren, Q. Jiang and J. Feng (2003). Parkin is recruited to the centrosome in response to inhibition of proteasomes. J. Cell Sci. 116: 4011-4019.

(57)     Y. Ren, J. Zhao and J. Feng (2003). Parkin binds to a/β tubulin and increases their ubiquitination and degradation. J. Neurosci. 23: 3316-3324.

(58)     P. Zhong, Z. Gu, X. Wang, H. Jiang, J. Feng, and Z. Yan (2003). Impaired modulation of GABAergic transmission by muscarinic receptors in a mouse transgenic model of Alzheimer's disease. J. Biol. Chem. 278: 26888-26896.

(59)     X. Ma, P. Zhong, Z. Gu, J. Feng and Z. Yan (2003). Muscarinic potentiation of GABAA receptor currents is gated by insulin signaling in prefrontal cortex. J. Neurosci. 23: 1159-1168.

(60)     V.A. Pieribone, B. Porton, B. Rendon, J. Feng, P. Greengard and H.-T. Kao (2002). Expression of synapsin III in nerve terminals and neurogenic regions of the adult brain. J. Comp. Neurol. 454: 105-14.

(61)     N. Carpino, R. Kobayashi, H. Zang, Y. Takahashi, S.-T. Jou, J. Feng, H. Nakajima and J.N. Ihle (2002).  Identification, cDNA cloning, and targeted deletion of p70, a novel, ubiquitously expressed SH3 domain-containing protein. Mol. Cell. Biol. 22: 7491-7500.

(62)     J. Feng, P. Chi, T.A. Blenpied, Y. Xu, A.M. Magarinos, A. Ferreira, R. Takahashi, H.-T. Kao, B.S. McEwen, T.A. Ryan, G.J. Augustine and P. Greengard (2002).  Regulation of neurotransmitter release by synapsin III. J. Neurosci. 22: 4372-4380.

(63)     X. Cai, J. Flores-Hernandez, J. Feng and Z. Yan (2002). Activity-dependent bi-directional regulation of GABAA receptor channels by serotonin 5-HT4 receptors in pyramidal neurons of the prefrontal cortex. J. Physiol. (Lond.) 540: 743-759.

(64)     J. Feng, X. Cai, J. Zhao and Z. Yan (2001). Serotonin receptors modulate GABAA receptor channels through activation of anchored protein kinase C in prefrontal cortical neurons. J. Neurosci. 21: 6502-6511.

(65)     C.A. Stafstrom-Davis, C.C. Ouimet, J. Feng, P.B. Allen, P. Greengard, T.A. Houpt (2001).  Impaired conditioned taste aversion learning in spinophilin knockout mice. Learn. Mem. 8: 272-278.

(66)     J. Feng, Z. Yan, A. Ferreira, K. Tomizawa, J.A. Liauw, M. Zhuo, P.B. Allen, C.C. Ouimet and P. Greengard (2000).  Spinophilin regulates the formation and function of dendritic spines. Proc. Nat. Acad. Sci. 97: 9287-9292.

(67)     A. Ferreira, H.-T. Kao, J. Feng, M. Rapoport and P. Greengard (2000).  Synapsin III: developmental expression, subcellular localization, and role in axon formation.  J. Neurosci. 20: 3736-3744.

(68)     D. Wang, J. Feng, R. Wen, J.-C. Marine, M.Y. Sangster, E. Parganas, C.W. Jackson, J.L. Cleveland, P.J. Murray and J.N. Ihle (2000).  Phospholipase C-g2 is essential in the functions of B cells and Fc receptors. Immunity 13: 25-35.

(69)     D. Wang, R. Moriggl, D. Stravopodis, N. Carpino, J.-C. Marine, S. Teglund, J. Feng and J.N. Ihle (2000).  A small amphipathic a-helical region is required for transcriptional activities and proteasome-dependent turnover of the tyrosine-phosphorylated Stat5. EMBO J. 19: 392-399.

(70)     Z. Yan, L. Hsieh-Wilson, J. Feng, K. Tomizawa, P.B. Allen, A.A. Fienberg, A.C. Nairn, and P. Greengard (1999). Protein phosphatase-1 modulation of neostriatal AMPA channels: regulation by DARPP-32 and spinophilin. Nature Neurosci. 2: 13-17.

(71)     Z. Yan, J. Feng, A.A. Fienberg and P. Greengard (1999).  D2 dopamine receptors induce MAPK and CREB phosphorylation in neurons. Proc. Nat. Acad. Sci. 96: 11607-11612.

(72)     P.B. Allen, L. Hsieh-Wilson, Z. Yan, J. Feng, C.C. Ouimet and P. Greengard (1999).  Control of protein phosphatase-1 in the dendrite. Biochem. Soc. Trans. 27: 543-546.

(73)     H.-T. Kao, B. Porton, A.J. Czernik, J. Feng, G. Yiu, M. Haring, F. Benfenati and P. Greengard (1998).  A third member of the synapsin gene family.  Proc. Natl. Acad. Sci. 95: 4667-4672.

(74)     F.W. Quelle, J. Wang, J. Feng, D. Wang, J.L. Cleveland, J.N. Ihle and G.P. Zembetti (1998).  Cytokine rescue of p53-dependent apoptosis and cell cycle arrest is mediated by distinct JAK Kinase signaling pathways. Genes Dev. 12: 1099-1107.

(75)     J.N. Ihle, D. Stravopodis, E. Parganas, W.E. Thierfelder, J. Feng, D. Wang and S. Teglund (1998).  The roles of Jaks and Stats in cytokine signaling. Cancer J. 4: S84-S91.

(76)     J.N. Ihle, W.E. Thierfelder, S. Teglund, D. Stravapodis, D. Wang, J. Feng and E. Parganas (1998). Signaling by the cytokine receptor superfamily. Ann. N Y Acad. Sci. 865: 1-9.

(77)     J. Feng, B.A. Witthuhn, T. Matsuda, F. Kohlhuber, I.M. Kerr and J.N. Ihle (1997). Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop.  Mol. Cell. Biol. 17: 2497-2501.

(78)     F. Kohlhuber, N.C. Rogers, D. Watling, J. Feng, D. Guschin, B.A. Witthuhn, S.V. Kotenko, S. Pestka, G.R. Stark, J.N. Ihle and I.M. Kerr (1997). A Jak1/Jak2 chimera can sustain interferon-a and -g response. Mol. Cell. Biol. 17: 695-706.

(79)     K. Shimoda, J. Feng, H. Murakami, S. Nagata, D. Watling, N.C. Rogers, G.R. Stark, I.M. Kerr and J.N. Ihle (1997).  Jak1 plays an essential role for receptor phosphorylation and Stat activation in response to G-CSF.  Blood  90: 597-604.