Peer-reviewed
publications:
(1)
Hu Z,
Li H, Jiang H, Ren Y, Yu X, Qiu J, Stablewski AB, Zhang B, Buck MJ, Feng J (2020). Transient Inhibition of
mTOR in Human Pluripotent Stem Cells Enables Robust Formation of Mouse-Human
Chimeric Embryos. Science Advances 6: eaaz0298
(2)
Lin L, Liu A, Li HQ, Feng J, Yan Z (2019) Inhibition of histone methyltransferases EHMT1/2 reverses b amyloid-induced loss of AMPAR currents in human stem cell-derived
cortical neurons. J. Alzheimer's Disease 70:1175-1185
(3)
Li H,
Jiang H, Yin X, Bard JE, Zhang B, Feng J
(2019). Attenuation
of PRRX2 and HEY2 enables efficient conversion of adult human skin fibroblasts
to neurons. Biochem Biophys Res Commun. 516:765-769.
(4)
H Li, H Jiang, B Zhang, J Feng (2018). Modeling Parkinson’s Disease Using Patient-specific
Induced Pluripotent Stem Cells. Journal of Parkinson’s Disease, 8:479–493
(5)
P Zhong, Z Hu, H Jiang, Z Yan, J Feng (2017). Dopamine
Induces Oscillatory Activities in Human Midbrain Neurons with Parkin Mutations.
Cell
Reports 19:1033-1044
(6)
Z Xu, X
(7)
J Feng (2016). Kinetic Barriers in
Transdifferentiation. Cell Cycle, 15:1019-1020
(8)
Z Xu, H
Jiang, P Zhong, Z Yan, S Chen, J Feng
(2016). Direct
Conversion of Human Fibroblasts to Induced Serotonergic Neurons. Molecular
Psychiatry, 21:62-70.
(9)
H Jiang, Z Xu, P Zhong, Y Ren, G Liang, HA
Schilling, Z Hu, Y Zhang, X Wang, S Chen, Z Yan, J Feng (2015). Cell Cycle and p53 Gate the Direct Conversion of
Human Fibroblasts to Dopaminergic Neurons. Nature Communications, 6: 10100.
(10)
Z Hu, J Pu, H Jiang, P Zhong, J Qiu, F Li, X
Wang, B Zhang, Z Yan, J Feng (2015).
Generation of Naivetropic Induced Pluripotent Stem Cells from Parkinson’s
Disease Patients for High Efficiency Genetic Manipulation and Disease Modeling.
Stem
Cells and Development. 24:2591-2604
(11)
J Pu, D
Frescas, B Zhang, J Feng (2015). Utilization of TALEN and CRISPR/Cas9
technologies for gene targeting and modification. Exp. Biol. Med. 240:1065-1070
(12)
Y Ren, H
Jiang, Z Hu, K Fan, J Wang, S Janoschka, X Wang, S Ge, J Feng (2015). Parkin Mutations Reduce the Complexity of
Neuronal Processes in iPSC-derived Human Neurons. Stem Cells, 33:68-78.
(13)
A Pliss, AN Kuzmin, AV Kachynski, H Jiang, Z Hu,
Y Ren, J Feng, PN Prasad (2013). Nucleolar
Molecular Signature of Pluripotent Stem Cells. Anal. Chem., 85:3545-3552
(14)
H Jiang, Y Ren, EY Yuen, P Zhong, M Ghaedi, Z
Hu, G Azabdaftari, K Nakaso, Z Yan, J
Feng (2012). Parkin Controls Dopamine Utilization in Human Midbrain
Dopaminergic Neurons Derived from Induced Pluripotent Stem Cells. Nature
Communications, 3:668. DOI 10.1038/ncomms1669.
(15)
O. Cooper, H. Seo, S. Andrabi, C.
Guardia-Laguarta, J. Graziotto, M. Sundberg, J. R. McLean, L. Carrillo-Reid, Z.
Xie, T. Osborn, G. Hargus, M. Deleidi, T. Lawson, H. Bogetofte, E.
Perez-Torres, L. Clark, C. Moskowitz, J. Mazzulli, L. Chen, L.
Volpicelli-Daley, N. Romero, H. Jiang, R. J. Uitti, Z. Huang, G. Opala, L. A.
Scarffe, V. L. Dawson, C. Klein, J. Feng,
O. A. Ross, J. Q. Trojanowski, V. M. Lee, K. Marder, D. J. Surmeier, Z. K.
Wszolek, S. Przedborski, D. Krainc, T. M. Dawson, O. Isacson (2012).
Pharmacological Rescue of Mitochondrial Deficits in iPSC-Derived Neural Cells
from Patients with Familial Parkinson’s Disease. Science Translational Medicine
4, 141ra90.
(16)
J Feng (2012). The
role of parkin in Parkinson’s disease: a stem cell perspective. Neurodegenerative
Disease Management, 2:239-241
(17)
J Pu, H Jiang, B Zhang, J Feng (2012). Redefining Parkinson's disease research using
induced pluripotent stem cells. Current Neurology and Neuroscience Reports.
12:392-398.
(18)
MD Garrick, L Zhao, JA Roth, H Jiang, J Feng, NJ Foot, H Dalton, S Kumar, LM
Garrick (2012). Isoform specific regulation of divalent metal (ion) transporter
(DMT1) by proteasomal degradation. BioMetals, 25:787-793.
(19)
JB Lee, J Wei,
(20)
Y. Ren, X.
Liu, S. Lesage, M. Cai, J. Pu, B. Zhang, A. Brice, J. Feng (2012). The
(21)
DJ Klionsky, FC Abdalla, ... J Feng, … Zuckerbraun B (2012). Guidelines for the use and
interpretation of assays for monitoring autophagy. Autophagy 8:445-544.
(over 100 authors in alphabetical order except the corresponding author).
(22)
S. M Choi, H. Liu, P. Chaudhari, Y. Kim, L.
Cheng, J. Feng, S. Sharkis, Z. Ye
and Y-Y Jang (2011) Reprogramming of EBV-immortalized B-lymphocyte cell lines
into induced pluripotent stem cells. Blood 118:1801-1805.
(23)
Y. Ren, H. Jiang, D. Ma, K. Nakaso, J. Feng (2011). Parkin Degrades
Estrogen Related Receptors to Limit the Expression of Monoamine Oxidases. Hum.
Mol. Genet. 20:1074-1083.
(24)
E.Y. Yuen, W. Liu, I.N. Karatsoreos, Y.
Ren, J. Feng, B.S. McEwen, Z. Yan.
(2011) Mechanisms for acute stress-induced enhancement of glutamatergic
transmission and working memory. Mol Psychiatry. 16:156-170
(25)
W. Liu, F. Dou, J. Feng, Z. Yan (2011) RACK1 is involved in b-amyloid impairment of muscarinic regulation of
GABAergic transmission. Neurobiol. Aging 32:1818-26.
(26)
B. Porton, R.M. Rodriguiz, L.E. Phillips, J.W. Gilbert,
J. Feng, P. Greengard, H.T. Kao,
W.C. Wetsel (2010) Mice lacking synapsin III show abnormalities in explicit
memory and conditioned fear. Genes Brain Behav. 9:257-268.
(27) H. Jiang,
D. Cheng, W. Liu, J. Peng, J. Feng
(2010). Protein Kinase C Inhibits Autophagy
and Phosphorylates LC3. Biochem Biophys Res Commun. 395:471-476.
(28)
J.A. Roth, S. Singleton, J. Feng, M. Garrick, P.N. Paradkar (2010) Parkin regulates metal
transport via proteasomal degradation of the 1B isoforms of divalent metal
transporter 1 (DMT1). J. Neurochem. 113:454-64.
(29) Y. Ren, H. Jiang, F. Yang, K. Nakaso, and J. Feng (2009). Parkin protects dopaminergic neurons against microtubule-depolymerizing toxins by attenuating MAP kinase activation. J. Biol. Chem. 284:4009-4017
(30) E.Y. Yuen, W. Liu, I.N. Karatsoreos, J. Feng, B.S. McEwen, and Z. Yan (2009). Acute Stress Enhances Glutamatergic Transmission in Prefrontal Cortex and Facilitates Working Memory. Proc. Nat. Acad. Sci. 106:14075-14079.
(31) Q. Jiang, Y. Ren, and J. Feng (2008). Direct Binding with Histone Deacetylase 6 Mediates the Reversible Recruitment of Parkin to the Centrosome. J. Neurosci. 28:12993–13002.
(32) M.M. Madden, W. Song, P.G. Martell, Y. Ren, J. Feng, and Q. Lin (2008). Substrate Properties of Ubiquitin Carboxyl-Terminally Derived Peptide Probes for Protein Ubiquitination. Biochem. 47:3636-3644.
(33) E.Y. Yuen, Q. Jiang, P. Chen, J. Feng, Z. Yan (2008). Activation of 5-HT2A/C Receptors Counteracts 5-HT1A Regulation of NMDAR Channels in Pyramidal Neurons of Prefrontal Cortex. J. Biol. Chem. 283:17194-17204.
(34) H.-T. Kao, P. Li, H.M. Chao, S. Janoschka, K. Pham, J. Feng, B.S. McEwen, P. Greengard, V.A. Pieribone, and B. Porton (2008). Early involvement of synapsin III in neural progenitor cell development in the adult hippocampus. J. Comp. Neurol. 507:1860-1870.
(35) G. Chen, P. Chen, H. Tan, D. Ma, F. Dou, J. Feng, Z. Yan (2008) Regulation of the NMDA receptor-mediated synaptic response by acetylcholinesterase inhibitors and its impairment in an animal model of Alzheimer’s disease. Neurobiol. Aging 29:1795-1804.
(36) Y. Ren and J. Feng (2007) Rotenone Selectively Kills Serotonergic Neurons through a Microtubule-dependent Mechanism. J. Neurochem. 103:303-311.
(37)
J. Feng (2006). Microtubule: a Common Target
for Parkin and Parkinson’s Disease Toxins. Neuroscientist. 12:469-476.
(38) W. Liu, E. Y. Yuen, P.B. Allen, J.
Feng, P. Greengard, and Z. Yan (2006). Adrenergic
modulation of NMDA receptors in prefrontal cortex is differentially regulated
by RGS proteins and spinophilin. Proc. Nat. Acad. Sci. 103:18338-18343.
(39)
Q.
Jiang, Z. Yan, and J. Feng (2006). Neurotrophic factors stabilize microtubules and
protect against rotenone toxicity on dopaminergic neurons. J. Biol. Chem. 281:29391-29400.
(40)
Q.
Jiang, Z. Yan, and J. Feng (2006). Activation
of Group III Metabotropic Glutamate Receptors Attenuates Rotenone Toxicity on
Dopaminergic Neurons through a Microtubule-dependent Mechanism. J.
Neurosci. 26:4318-4328.
(41)
H.
Jiang, Q. Jiang, W. Liu and J. Feng (2006). Parkin Suppresses the
Expression of Monoamine Oxidases. J. Biol. Chem. 281:8591-8599.
(42)
P.B.
Allen, V. Zachariou, P. Svenningsson, A.C. Lepore, D. Centonze, C. Costa, S.
Rossi, G. Bender, G. Chen, J. Feng,
G.L. Snyder, G. Bernardi, E.J. Nestler, Z. Yan, P. Calabresi, P. Greengard
(2006). Distinct roles for spinophilin and neurabin in dopamine-mediated
plasticity. Neurosci. 140:897-911
(43)
X.
Wang, Z. Gu, P. Zhong, G. Chen, J. Feng,
and Z. Yan (2006). Aberrant regulation of NMDAR functions by dopamine D4
receptors in rats after phencyclidine exposure. Mol. Cell. Neurosci. 31:15-25.
(44)
Y.
Ren, W. Liu, H. Jiang, Q. Jiang, and J.
Feng (2005). Selective Vulnerability of Dopaminergic Neurons to Microtubule
Depolymerization. J. Biol. Chem. 280:34105-34112.
(45)
F.
Yang, Q. Jiang, J. Zhao, Y. Ren, M.D. Sutton and J. Feng (2005). Parkin Stabilizes Microtubules through Strong
Binding Mediated by Three Independent Domains. J. Biol. Chem. 280:17154-17162.
(46)
E.Y.
Yuen, Q. Jiang, J. Feng, and Z. Yan
(2005). Microtubule regulation of NMDA receptor channels in neurons. J.
Biol. Chem. 280:29420-29427.
(47)
E.Y.
Yuen, Q. Jiang, P. Chen, Z. Gu, J. Feng
and Z. Yan (2005). Serotonin 5-HT1A receptors regulate NMDA receptor channels
through a microtubule-dependent mechanism. J. Neurosci. 25:5488-5501.
(48) H. Jiang, Q. Jiang and J. Feng (2004). Parkin Increases
Dopamine Uptake by Enhancing the Cell Surface Expression of Dopamine
Transporter. J. Biol. Chem. 279:54380-54386.
(49) H. Jiang, Y. Ren, J. Zhao and J. Feng (2004). Parkin
protects human dopaminergic neuroblastoma cells against dopamine-induced apoptosis.
Hum.
Mol. Genet. 13: 1745-1754.
(50) Z. Yan and J. Feng (2004). Alzheimer’s disease: interactions between
cholinergic functions and b-amyloid. Curr. Alz. Res. 1:241-248 (review).
(51) Q. Wang, J. Zhao, A.E. Brady, J. Feng, P.B. Allen, R.J. Lefkowitz, P.
Greengard, and L.E. Limbird (2004). Spinophilin blocks arrestin actions in
vitro and in vivo at G protein-coupled receptors. Science 304: 1940-1944.
(52) D. Gitler, Y. Takagishi, J. Feng, Y. Ren, R. Rodriguiz, W.
Wetsel, P. Greengard and G. J. Augustine (2004). Different presynaptic roles of
synapsins at excitatory and inhibitory synapses. J. Neurosci. 24:11368
–11380.
(53) D. Gitler, Y. Xu, H.-T. Kao, D. Lin,
S. Lim, J. Feng, P. Greengard and
G.J. Augustine (2004). Molecular
determinants of synapsin targeting to presynaptic terminals. J. Neurosci. 24: 3711-3720.
(54) T. Matsuda, J. Feng, B.A. Witthuhn, Y. Sekine and J.N. Ihle (2004). Determination
of the transphosphorylation sites of Jak2 kinase. Biochem. Biophys. Res. Commun.
325:586-594.
(55) J. Feng (2003).
Genetic factors in Parkinson’s disease and potential therapeutic targets. Curr.
Neuropharmacol. 1: 301-313 (review).
(56) J. Zhao, Y. Ren, Q. Jiang and J. Feng (2003). Parkin is recruited to
the centrosome in response to inhibition of proteasomes. J. Cell Sci. 116:
4011-4019.
(57) Y. Ren, J. Zhao and J. Feng (2003). Parkin binds to a/β tubulin and increases their ubiquitination
and degradation. J. Neurosci.
23: 3316-3324.
(58) P. Zhong, Z. Gu, X. Wang, H. Jiang, J. Feng, and Z. Yan
(2003). Impaired modulation of GABAergic
transmission by muscarinic receptors in a mouse transgenic model of Alzheimer's
disease. J. Biol. Chem. 278: 26888-26896.
(59) X. Ma, P. Zhong, Z. Gu, J. Feng
and Z. Yan (2003). Muscarinic
potentiation of GABAA receptor currents is gated by insulin
signaling in prefrontal cortex. J. Neurosci. 23: 1159-1168.
(60) V.A. Pieribone, B. Porton, B. Rendon,
J. Feng, P. Greengard and H.-T. Kao
(2002). Expression of synapsin III in nerve terminals and neurogenic regions of
the adult brain. J. Comp. Neurol. 454: 105-14.
(61) N. Carpino,
R. Kobayashi, H. Zang, Y. Takahashi, S.-T. Jou, J. Feng, H. Nakajima and
J.N. Ihle (2002).
Identification, cDNA cloning, and targeted deletion of p70, a novel,
ubiquitously expressed SH3 domain-containing protein. Mol.
Cell. Biol. 22: 7491-7500.
(62) J. Feng, P.
Chi, T.A. Blenpied, Y. Xu, A.M. Magarinos, A. Ferreira, R. Takahashi, H.-T.
Kao, B.S. McEwen, T.A. Ryan, G.J. Augustine and P. Greengard (2002). Regulation of neurotransmitter release by
synapsin III. J. Neurosci. 22: 4372-4380.
(63)
X.
Cai, J. Flores-Hernandez, J. Feng and Z. Yan (2002). Activity-dependent
bi-directional regulation of GABAA receptor channels by serotonin
5-HT4 receptors in pyramidal neurons of the prefrontal cortex. J.
Physiol. (Lond.) 540: 743-759.
(64)
J. Feng, X. Cai, J. Zhao and Z. Yan (2001).
Serotonin receptors modulate GABAA receptor channels through
activation of anchored protein kinase C in prefrontal cortical neurons. J.
Neurosci. 21: 6502-6511.
(65)
(66) J. Feng, Z.
Yan, A. Ferreira, K. Tomizawa, J.A. Liauw,
M. Zhuo, P.B. Allen, C.C. Ouimet and P. Greengard (2000). Spinophilin regulates the formation and
function of dendritic spines. Proc. Nat. Acad. Sci. 97: 9287-9292.
(67) A. Ferreira, H.-T. Kao, J. Feng, M. Rapoport and P. Greengard
(2000). Synapsin III: developmental
expression, subcellular localization, and role in axon formation. J. Neurosci. 20: 3736-3744.
(68)
D.
Wang, J. Feng, R. Wen, J.-C. Marine,
M.Y. Sangster, E. Parganas, C.W. Jackson, J.L. Cleveland, P.J. Murray and J.N.
Ihle (2000). Phospholipase C-g2 is essential in the functions of B
cells and Fc receptors. Immunity 13: 25-35.
(69)
D. Wang, R. Moriggl, D. Stravopodis, N. Carpino, J.-C.
Marine,
(70) Z. Yan, L. Hsieh-Wilson, J. Feng, K. Tomizawa, P.B. Allen, A.A.
Fienberg, A.C. Nairn, and P. Greengard (1999). Protein phosphatase-1 modulation
of neostriatal AMPA channels: regulation by DARPP-32 and spinophilin. Nature
Neurosci. 2: 13-17.
(71) Z. Yan, J. Feng, A.A. Fienberg and P. Greengard (1999). D2 dopamine receptors induce MAPK and CREB
phosphorylation in neurons. Proc. Nat. Acad. Sci. 96: 11607-11612.
(72) P.B. Allen, L. Hsieh-Wilson, Z. Yan, J. Feng, C.C. Ouimet and P. Greengard
(1999). Control of protein phosphatase-1
in the dendrite. Biochem. Soc. Trans. 27: 543-546.
(73) H.-T. Kao, B. Porton, A.J. Czernik, J. Feng, G. Yiu, M. Haring, F.
Benfenati and P. Greengard (1998). A
third member of the synapsin gene family.
Proc. Natl. Acad. Sci. 95:
4667-4672.
(74) F.W. Quelle, J. Wang, J. Feng, D. Wang, J.L. Cleveland, J.N.
Ihle and G.P. Zembetti (1998). Cytokine
rescue of p53-dependent apoptosis and cell cycle arrest is mediated by distinct
JAK Kinase signaling pathways. Genes Dev. 12: 1099-1107.
(75) J.N. Ihle, D. Stravopodis, E.
Parganas, W.E. Thierfelder, J. Feng,
D. Wang and S. Teglund (1998). The roles
of Jaks and Stats in cytokine signaling. Cancer J. 4: S84-S91.
(76) J.N. Ihle, W.E. Thierfelder, S.
Teglund, D. Stravapodis, D. Wang, J.
Feng and E. Parganas (1998). Signaling by the cytokine receptor
superfamily. Ann. N Y Acad. Sci. 865: 1-9.
(77) J. Feng, B.A.
Witthuhn, T. Matsuda, F. Kohlhuber, I.M. Kerr and J.N. Ihle (1997). Activation
of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop. Mol. Cell. Biol. 17: 2497-2501.
(78) F. Kohlhuber, N.C. Rogers, D.
Watling, J. Feng, D. Guschin, B.A.
Witthuhn, S.V. Kotenko, S. Pestka, G.R. Stark, J.N. Ihle and I.M. Kerr (1997).
A Jak1/Jak2 chimera can sustain interferon-a and -g response. Mol. Cell. Biol. 17: 695-706.
(79) K. Shimoda, J. Feng, H. Murakami, S. Nagata, D. Watling, N.C. Rogers, G.R.
Stark, I.M. Kerr and J.N. Ihle (1997).
Jak1 plays an essential role for receptor phosphorylation and Stat
activation in response to G-CSF. Blood 90:
597-604.