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Human YY1
Product Description:
The multi-functional transcription factor and nuclear matrix protein YY1 (Ying
Yang 1) was first discovered in 1991 for its ability to dually trans-activate
or trans-repress gene promoters. YY1 has been studied extensively across
multiple disciplines. At least 30 cellular or viral protein factors have been
found to physically interact with YY1 protein, and over 70 gene promoters have
been found to be regulated by YY1. cDNAs encoding YY1 or YY1 homologs have been
cloned from humans, rodents, zebrafish, frogs, fruitfly, and maize. Human and
mouse YY1 protein sequences are highly homologous; regions of near 100%
sequence homology include the acidic domain, glycine-rich domain, histidine-rich
domain, and the zinc finger domain. YY1 is usually expressed at higher levels
in proliferating cells. Expression of YY1 is typically low in post-mitotic
tissues, and can be down-regulated during cell differentiation. The consensus
promoter DNA sequence recognized by YY1 is (C/g/a)(G/t)(G/t/a)CATN(T/a)(T/g/c).
Although human YY1 has a calculated molecular weight of ~45 kDa, it exhibits a
prominently retarded gel mobility corresponding to ~70 kDa in SDS-PAGE.