Our websites: www.acsu.buffalo.edu/~chunglee or www.bmrservice.com

SRF Antibody

Background: Human SRF (508 amino acids) is a member of the MADS box family of transcription factors. SRF regulates many genes involved in cell cycle control, differentiation, apoptosis, and embryonic development through interactions with the conserved promoter serum response element. The diverse functions of SRF are also mediated through the recruitment of many general and sequence-specific transcription factors, highlighting the central role of protein interaction in transcriptional regulation by SRF. SRF itself can be activated by many agents including serum, cytokines, growth factors, tumor promoters, LPS, and UV light. The gene is a primary target of the MAPK signal transduction pathway through the ternary complex factors (TCFs). RhoA signaling also regulates the activity of SRF during muscle differentiation. 

            Antibody Description: The polyclonal antibody was produced by immunizing rabbits with a synthetic peptide 

            corresponding to a C-terminal region (400-450) of human SRF. The product is for research use only.