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Human Growth Hormone (GH)

Product Description: Human growth hormone (GH), also known as somatotropin, is synthesized in the anterior pituitary as a 217-amino acid precursor, which is further cleaved to generate the mature 191-amino acid (22 kDa) cytokine. Through binding to the GH receptor, it exhibits potent pleiotropic biological effects in an IGF1-dependent and -independent manner. Prominent signal transduction events activated by GH include the JAK/STAT and MAPK/ERK pathways, culminating in IGF1 production and growth promotion. Other significant effects of GH are activation of lipolysis, stimulation of protein synthesis, and augmentation of immune function. Since this function of GH is generally anabolic, it has been explored clinically to treat short stature in children. Bovine GH is used to increase milk production in dairy cows. Human and bovine GH amino acid sequences are 67% homologous. The human GH is over-produced and purified from E. coli. The product is for research use only.