The Biophysics of Cell Signaling in Immunology and Neuroscience.
Our research interests lie at the interface of nanotechnology and cellular biophysics, and focus on the physics of signaling at the cell membrane. Some of us develop and investigate thermo-magnetic remote stimulation of proteins and cells using nanotechnology to study signaling networks. Others in our group investigate the cell membrane ultra-structure and how it modulates cell signaling for which we have developed two methods to image the nanoscale structure. Currently, we investigate how temperature, calcium concentration, protein-dimerization and cholesterol influence the ultrastructure, and how this structure modulates immune cell signaling.
More details are here:
1. Local magnetic nanoparticle heating for protein and cell stimulation
2. Thermal noise imaging to resolve membrane ultra-structure
3. bimFCS - studying the influence of membrane ultra-structure on immune cell signaling:
- How do adjuvants or fever help immune signaling?
- How does Ca++ influence membrane structure?
We have several NIH- and HFSP-funded post-doctoral positions available. We are looking for one or two people with backgrounds in Neuroscience, Bioengineering or Biophysics to join our efforts in thermomagnetic stiumulation of cells. In addition, we want a person with Biophysics or Immunology background to join our studies of the effects of adjuvants on the cell. Please apply with your CV to Arnd Pralle.
We are always looking for motivated, hard-working graduate and undergraduate students to join us. Please email Arnd Pralle for more information.
|NIH EUREKA award (R01 MH094730, 4 years, $1.3 Mio) from the NIMH to bring magnetogenetics into mice neuroscience|
|NIH R21 award (R21 AI097879-01, 2 years, $0.5 Mio) from the NIAID to invesitgate the membrane biophysics of adjuvants mediated immunomodulation|
|Human Frontier Sciene Program award (HFSP RGP0052/2012, 3 years, $1.2 Mio) to optimize thermomagnetic stimulation and to genetically encode it|
|MRI 0923133 ($0.5 Mio) to establish a confocal microscopy facility for pulsed-light imaging for FLIM and FCS between Biology and Physics|
- Evan's paper is submitted to Cell Cycle
- Jin, Rahul, Muhammed, and Arnd present posters and a talk at 59th Ann. Biophysics Conf
- the bimFCS is finally accepted and in-press at PLOS one
- Congratulate Idoia to securing a competitive 3-yr fellowship from the Basque Gov
------- 2014 -------
Aug - Nov 2014
- Arnd spends a sabbatical with W. Parak the U Marburg and S. Hell at the MPI in Göttingen
- Arnd presents at the HFSP meeting in Lugano
- Yun-Hsiang's paper is accepted
- group dinner to honor Kelly's move (pic)
- Arnd gives a colloquim at U Akron
- welcome Idoia as postdoc
- Jin, Muhammed and Arnd present at 58th Ann. Biophysics Conf
------- 2013 -------
- Heng leaves for her new job at Illumina, CA
- Arnd gives a talk at the SUNY BRAIN meeting
- Arnd is invited speaker at Nanoscience and Healthcare in Paris
- Arnd gives a colloquim at U Mass Medschool
- Yunhsiang defends his Ph.D. thesis - congratulations! well deserved
- summer w 3 manuscripts submitted
- Arnd presents at the HFSP meeting in Strassbourg - the team gets together
- Arnd participates in the NIH EUREKA review panel
- Arnd talks at the ICREA Symposioum in Barcelona
- Junhong Choi leaves us for Stanford grad school - good luck
- Heng and Junhong graduate
- welcome Shahnaz as postdoc
- Rahul Munshi receives Cambi award and joins us
- welcome Jason to our group
- Hongwang presents at the APS meeting
- congrats to Junhong for being accepted to grad schoo in Stanford, Urbana, Ann Arbor and Chicago
- Arnd presented an invited talk at the BiOS/Photonics West SPIE conference
- Heng, Jin, Muhammed, Yunhsiang and Junhong present at 57th Ann. Biophysics Conf
- a video summary of our publication with Sheldon Park's group has been posted
------- 2012 -------
- Junhong receives a Honors College Research Creativity Grant. Congrats!
- Heng defends her Ph.D. thesis - congratulations! well done
- we've submitted a record 6 abstracts for the Biophysics conference in Feb. 2013
- Evan's paper on Thermal modulation of lymphocyte activation gets submitted!
- Arnd is interviewed by NOVA ScienceNOW and Discovery Magazine for future episodes on brain stimulation techniques
- Katie moves to Cornell to begin her graduate studies - we wish her success
- Arnd presents Yunhsiang's results at the Single Molecule GRC in Vermont
- Physics UGs Junhong Choi and Zach van Zant join the lab to do their honors theses
- Katie graduates with honors and decides to spend the summer in the lab
- Graduate student Maral and Jin both receive a Cambi fellowhip to pursuit Biophysics research
- Katie presents her honors thesis on modeling nanoparticle heating
- Arnd presents a talk on membrane structure at UIUC
- Katie, Heng, Muhammed, Yunhsiang and Arnd went to the Biophysics conference and presented their work
older news here