Lighthouse Medical Clinic was established in 2001 by a group of ambitious medical students from UB. The clinic's story dates back to 1998, when two first-year students, Richard Newell and Gerard Silva, looked up from their textbooks and decided to make a difference.

The clinic was first located in the basement of Resurrection Lutheran Church at the corner of Genesee and Doat streets. Once it became apparent that the clinic would be successful, the church purchased the building next door. Various funding sources, including the church's congregation, provided support for the clinic to supplement funds that students raise each year. In 2012, Lighthouse entered into a new partnership with Group Ministries and moved to its current location at Jefferson Avenue and East Utica Street.

In addition to providing routine, non-emergent care, clinic staff conduct physicals, screen for chronic conditions such as diabetes and hypertension, offer counseling and treatment for sexually transmitted diseases including HIV, and provide referrals as needed. Some generic medications are available free of charge. The clinic also partners with clinical social workers who help enroll individuals and families in health insurance plans, including Medicaid, and Child and/or Family Health Plus.